A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk

Murphy, Neil; Achaintre, David; Zamora-Ros, Raul; Jenab, Mazda; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Savoye, Isabelle; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Aleksandrova, Krasimira; Tjønneland, Anne; Kyrø, Cecilie; Overvad, Kim; Quirós, José Ramón; Sánchez, María José; Altzibar, Jone M.; Huerta, José María; Barricarte, Aurelio; Khaw, Kay‐Tee; Bradbury, Kathryn E.; Pérez Cornago, Aurora; Trichopoulou, Antonia; Karakatsani, Anna; Peppa, Eleni; Palli, Domenico; Grioni, Sara; Tumino, Rosario; Sacerdote, Carlotta; Panico, Salvatore; Bueno de Mesquita, H. Bas; Peeters, Petra H. M.; Rutegård, Martin; Johansson, Ingegerd; Freisling, Heinz; Noh, Hwayoung; Cross, Amanda J.; Vineis, Paolo; Tsilidis, Kostas; Gunter, Marc J.; Scalbert, Augustin

A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk

Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested wi...

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Detalles Bibliográficos
Autores:	Murphy, Neil, Achaintre, David, Zamora-Ros, Raul, Jenab, Mazda, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Savoye, Isabelle, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Quirós, José Ramón, Sánchez, María José, Altzibar, Jone M., Huerta, José María, Barricarte, Aurelio, Khaw, Kay‐Tee, Bradbury, Kathryn E., Pérez Cornago, Aurora, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno de Mesquita, H. Bas, Peeters, Petra H. M., Rutegård, Martin, Johansson, Ingegerd, Freisling, Heinz, Noh, Hwayoung, Cross, Amanda J., Vineis, Paolo, Tsilidis, Kostas, Gunter, Marc J., Scalbert, Augustin
Tipo de recurso:	artículo
Fecha de publicación:	2018
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/175514
Acceso en línea:	https://hdl.handle.net/2445/175514
Access Level:	acceso abierto
Palabra clave:	Marcadors bioquímics Càncer colorectal Estudi de casos Polifenols Biochemical markers Colorectal cancer Case studies Polyphenols

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spelling	A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer RiskMurphy, NeilAchaintre, DavidZamora-Ros, RaulJenab, MazdaBoutron-Ruault, Marie-ChristineCarbonnel, FranckSavoye, IsabelleKaaks, RudolfKühn, TilmanBoeing, HeinerAleksandrova, KrasimiraTjønneland, AnneKyrø, CecilieOvervad, KimQuirós, José RamónSánchez, María JoséAltzibar, Jone M.Huerta, José MaríaBarricarte, AurelioKhaw, Kay‐TeeBradbury, Kathryn E.Pérez Cornago, AuroraTrichopoulou, AntoniaKarakatsani, AnnaPeppa, EleniPalli, DomenicoGrioni, SaraTumino, RosarioSacerdote, CarlottaPanico, SalvatoreBueno de Mesquita, H. BasPeeters, Petra H. M.Rutegård, MartinJohansson, IngegerdFreisling, HeinzNoh, HwayoungCross, Amanda J.Vineis, PaoloTsilidis, KostasGunter, Marc J.Scalbert, AugustinMarcadors bioquímicsCàncer colorectalEstudi de casosPolifenolsBiochemical markersColorectal cancerCase studiesPolyphenolsPolyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (qvalues ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log2 -transformed multivariable models, equol (odds ratio [OR] per log2 -value, 0.86, 95% confidence interval [95% CI] = 0.79-0.93; qvalue = 0.01) and homovanillic acid (OR per log2 -value, 1.46, 95% CI = 1.16-1.84; qvalue = 0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR = 0.61, 95% CI = 0.41-0.91, ptrend = 0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR = 1.72, 95% CI = 1.17-2.53, ptrend < 0.0001). No heterogeneity for these associations was observed by sex and across other colon cancer risk factors. The remaining polyphenols were not associated with colon cancer risk. Higher equol concentrations were associated with lower risk, and higher homovanillic acid concentrations were associated with greater risk of colon cancer. These findings support a potential role for specific polyphenols in colon tumorigenesis.Wiley2021202120182021info:eu-repo/semantics/article12 p.application/pdfhttps://hdl.handle.net/2445/175514Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1002/ijc.31563International Journal of Cancer, 2018, vol. 143, issue. 7, p. 1620-1631https://doi.org/10.1002/ijc.31563cc by-nc (c) Murphy, Neil et al., 2018http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1755142026-05-29T05:05:01Z
dc.title.none.fl_str_mv	A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk
title	A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk
spellingShingle	A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk Murphy, Neil Marcadors bioquímics Càncer colorectal Estudi de casos Polifenols Biochemical markers Colorectal cancer Case studies Polyphenols
title_short	A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk
title_full	A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk
title_fullStr	A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk
title_full_unstemmed	A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk
title_sort	A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk
dc.creator.none.fl_str_mv	Murphy, Neil Achaintre, David Zamora-Ros, Raul Jenab, Mazda Boutron-Ruault, Marie-Christine Carbonnel, Franck Savoye, Isabelle Kaaks, Rudolf Kühn, Tilman Boeing, Heiner Aleksandrova, Krasimira Tjønneland, Anne Kyrø, Cecilie Overvad, Kim Quirós, José Ramón Sánchez, María José Altzibar, Jone M. Huerta, José María Barricarte, Aurelio Khaw, Kay‐Tee Bradbury, Kathryn E. Pérez Cornago, Aurora Trichopoulou, Antonia Karakatsani, Anna Peppa, Eleni Palli, Domenico Grioni, Sara Tumino, Rosario Sacerdote, Carlotta Panico, Salvatore Bueno de Mesquita, H. Bas Peeters, Petra H. M. Rutegård, Martin Johansson, Ingegerd Freisling, Heinz Noh, Hwayoung Cross, Amanda J. Vineis, Paolo Tsilidis, Kostas Gunter, Marc J. Scalbert, Augustin
author	Murphy, Neil
author_facet	Murphy, Neil Achaintre, David Zamora-Ros, Raul Jenab, Mazda Boutron-Ruault, Marie-Christine Carbonnel, Franck Savoye, Isabelle Kaaks, Rudolf Kühn, Tilman Boeing, Heiner Aleksandrova, Krasimira Tjønneland, Anne Kyrø, Cecilie Overvad, Kim Quirós, José Ramón Sánchez, María José Altzibar, Jone M. Huerta, José María Barricarte, Aurelio Khaw, Kay‐Tee Bradbury, Kathryn E. Pérez Cornago, Aurora Trichopoulou, Antonia Karakatsani, Anna Peppa, Eleni Palli, Domenico Grioni, Sara Tumino, Rosario Sacerdote, Carlotta Panico, Salvatore Bueno de Mesquita, H. Bas Peeters, Petra H. M. Rutegård, Martin Johansson, Ingegerd Freisling, Heinz Noh, Hwayoung Cross, Amanda J. Vineis, Paolo Tsilidis, Kostas Gunter, Marc J. Scalbert, Augustin
author_role	author
author2	Achaintre, David Zamora-Ros, Raul Jenab, Mazda Boutron-Ruault, Marie-Christine Carbonnel, Franck Savoye, Isabelle Kaaks, Rudolf Kühn, Tilman Boeing, Heiner Aleksandrova, Krasimira Tjønneland, Anne Kyrø, Cecilie Overvad, Kim Quirós, José Ramón Sánchez, María José Altzibar, Jone M. Huerta, José María Barricarte, Aurelio Khaw, Kay‐Tee Bradbury, Kathryn E. Pérez Cornago, Aurora Trichopoulou, Antonia Karakatsani, Anna Peppa, Eleni Palli, Domenico Grioni, Sara Tumino, Rosario Sacerdote, Carlotta Panico, Salvatore Bueno de Mesquita, H. Bas Peeters, Petra H. M. Rutegård, Martin Johansson, Ingegerd Freisling, Heinz Noh, Hwayoung Cross, Amanda J. Vineis, Paolo Tsilidis, Kostas Gunter, Marc J. Scalbert, Augustin
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Marcadors bioquímics Càncer colorectal Estudi de casos Polifenols Biochemical markers Colorectal cancer Case studies Polyphenols
topic	Marcadors bioquímics Càncer colorectal Estudi de casos Polifenols Biochemical markers Colorectal cancer Case studies Polyphenols
description	Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (qvalues ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log2 -transformed multivariable models, equol (odds ratio [OR] per log2 -value, 0.86, 95% confidence interval [95% CI] = 0.79-0.93; qvalue = 0.01) and homovanillic acid (OR per log2 -value, 1.46, 95% CI = 1.16-1.84; qvalue = 0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR = 0.61, 95% CI = 0.41-0.91, ptrend = 0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR = 1.72, 95% CI = 1.17-2.53, ptrend < 0.0001). No heterogeneity for these associations was observed by sex and across other colon cancer risk factors. The remaining polyphenols were not associated with colon cancer risk. Higher equol concentrations were associated with lower risk, and higher homovanillic acid concentrations were associated with greater risk of colon cancer. These findings support a potential role for specific polyphenols in colon tumorigenesis.
publishDate	2018
dc.date.none.fl_str_mv	2018 2021 2021 2021
dc.type.none.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/175514
url	https://hdl.handle.net/2445/175514
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1002/ijc.31563 International Journal of Cancer, 2018, vol. 143, issue. 7, p. 1620-1631 https://doi.org/10.1002/ijc.31563
dc.rights.none.fl_str_mv	cc by-nc (c) Murphy, Neil et al., 2018 http://creativecommons.org/licenses/by-nc/3.0/es/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc by-nc (c) Murphy, Neil et al., 2018 http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	12 p. application/pdf
dc.publisher.none.fl_str_mv	Wiley
publisher.none.fl_str_mv	Wiley
dc.source.none.fl_str_mv	Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,811543

A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk

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