A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk

Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested wi...

Descripción completa

Detalles Bibliográficos
Autores: Murphy, Neil, Achaintre, David, Zamora-Ros, Raul, Jenab, Mazda, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Savoye, Isabelle, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Quirós, José Ramón, Sánchez, María José, Altzibar, Jone M., Huerta, José María, Barricarte, Aurelio, Khaw, Kay‐Tee, Bradbury, Kathryn E., Pérez Cornago, Aurora, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno de Mesquita, H. Bas, Peeters, Petra H. M., Rutegård, Martin, Johansson, Ingegerd, Freisling, Heinz, Noh, Hwayoung, Cross, Amanda J., Vineis, Paolo, Tsilidis, Kostas, Gunter, Marc J., Scalbert, Augustin
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/175514
Acceso en línea:https://hdl.handle.net/2445/175514
Access Level:acceso abierto
Palabra clave:Marcadors bioquímics
Càncer colorectal
Estudi de casos
Polifenols
Biochemical markers
Colorectal cancer
Case studies
Polyphenols
Descripción
Sumario:Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (qvalues ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log2 -transformed multivariable models, equol (odds ratio [OR] per log2 -value, 0.86, 95% confidence interval [95% CI] = 0.79-0.93; qvalue = 0.01) and homovanillic acid (OR per log2 -value, 1.46, 95% CI = 1.16-1.84; qvalue = 0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR = 0.61, 95% CI = 0.41-0.91, ptrend = 0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR = 1.72, 95% CI = 1.17-2.53, ptrend < 0.0001). No heterogeneity for these associations was observed by sex and across other colon cancer risk factors. The remaining polyphenols were not associated with colon cancer risk. Higher equol concentrations were associated with lower risk, and higher homovanillic acid concentrations were associated with greater risk of colon cancer. These findings support a potential role for specific polyphenols in colon tumorigenesis.

Similares en LA Referencia