Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry

Background: Pediatric-onset familial inflammatory bowel disease (IBD) may differ from sporadic pediatric-onset IBD in its genetic and environmental background and may have distinct clinical and therapeutic implications. Objective: To evaluate the influence of a positive family history of IBD on the...

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Autores: González-Muñoza, C, Giordano, A, Ricart, E, Nos, P, Iglesias, E, Gisbert, JP, García-López, S, Mesonero, F, Pascual, I, Tardillo, C, Rivero, M, Riestra, S, Mañosa, M, Zabana, Y, Gomollón, F, Calvet, X, García-Sepulcre, MF, Gutiérrez, A, Pérez-Calle, JL, Sierra-Ausín, M, Bermejo, F, Arias, L, Barreiro-de Acosta, M, Barrio, J, Lorente, R, Guardiola, J, Varela, P, Ponferrada-Díaz, A, Marín-Jiménez, I, Pascual, CM, Garcia-Planella, E, Domènech, E
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p19907
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19907
Access Level:acceso abierto
Palavra-chave:pediatric
familial history
inflammatory bowel disease
surgery
biologicals
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spelling Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA RegistryGonzález-Muñoza, CGiordano, ARicart, ENos, PIglesias, EGisbert, JPGarcía-López, SMesonero, FPascual, ITardillo, CRivero, MRiestra, SMañosa, MZabana, YGomollón, FCalvet, XGarcía-Sepulcre, MFGutiérrez, APérez-Calle, JLSierra-Ausín, MBermejo, FArias, LBarreiro-de Acosta, MBarrio, JLorente, RGuardiola, JVarela, PPonferrada-Díaz, AMarín-Jiménez, IPascual, CMGarcia-Planella, EDomènech, Epediatricfamilial historyinflammatory bowel diseasesurgerybiologicalsBackground: Pediatric-onset familial inflammatory bowel disease (IBD) may differ from sporadic pediatric-onset IBD in its genetic and environmental background and may have distinct clinical and therapeutic implications. Objective: To evaluate the influence of a positive family history of IBD on the use of medical therapies and surgical interventions in adult patients with pediatric-onset IBD. Methods: Retrospective case-control study using the Spanish ENEIDA registry, including adults diagnosed with pediatric-onset IBD since 2006. Familial forms (FFs) (defined by a first-degree relative with IBD) and sporadic forms (SF) (with no relatives of any grade with IBD) were matched 1:4 by type of IBD, sex, age at IBD diagnosis, disease location, disease pattern, development of perianal disease and smoking status at diagnosis. The study outcomes were the use of immunomodulators, biological therapies, intestinal surgery, and perianal surgery during follow-up. Results: Six-hundred and fifty-five Crohn's disease (CD) (131 FF) and 440 ulcerative colitis (UC) (88 FF) patients were included. Immunomodulators, biological therapy, and intestinal surgery were used evenly among FF and SF patients for both UC and CD. However, a higher requirement for perianal surgery among FF-CD patients (18.3% vs. 10.5%, p = 0.014), together with a shorter time to perianal surgery (11 vs. 20 months, log-rank p = 0.004), was observed. Conclusions: Patients with FF of pediatric-onset IBD do not exhibit an increased use of immunomodulators, biological agents, or intestinal surgery, but do exhibit a higher need for perianal surgery, as compared to patients with SF pediatric-onset IBD.MDPI2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19907Journal of Clinical MedicineISSN: 20770383reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p199072026-06-14T12:41:47Z
dc.title.none.fl_str_mv Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
title Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
spellingShingle Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
González-Muñoza, C
pediatric
familial history
inflammatory bowel disease
surgery
biologicals
title_short Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
title_full Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
title_fullStr Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
title_full_unstemmed Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
title_sort Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
dc.creator.none.fl_str_mv González-Muñoza, C
Giordano, A
Ricart, E
Nos, P
Iglesias, E
Gisbert, JP
García-López, S
Mesonero, F
Pascual, I
Tardillo, C
Rivero, M
Riestra, S
Mañosa, M
Zabana, Y
Gomollón, F
Calvet, X
García-Sepulcre, MF
Gutiérrez, A
Pérez-Calle, JL
Sierra-Ausín, M
Bermejo, F
Arias, L
Barreiro-de Acosta, M
Barrio, J
Lorente, R
Guardiola, J
Varela, P
Ponferrada-Díaz, A
Marín-Jiménez, I
Pascual, CM
Garcia-Planella, E
Domènech, E
author González-Muñoza, C
author_facet González-Muñoza, C
Giordano, A
Ricart, E
Nos, P
Iglesias, E
Gisbert, JP
García-López, S
Mesonero, F
Pascual, I
Tardillo, C
Rivero, M
Riestra, S
Mañosa, M
Zabana, Y
Gomollón, F
Calvet, X
García-Sepulcre, MF
Gutiérrez, A
Pérez-Calle, JL
Sierra-Ausín, M
Bermejo, F
Arias, L
Barreiro-de Acosta, M
Barrio, J
Lorente, R
Guardiola, J
Varela, P
Ponferrada-Díaz, A
Marín-Jiménez, I
Pascual, CM
Garcia-Planella, E
Domènech, E
author_role author
author2 Giordano, A
Ricart, E
Nos, P
Iglesias, E
Gisbert, JP
García-López, S
Mesonero, F
Pascual, I
Tardillo, C
Rivero, M
Riestra, S
Mañosa, M
Zabana, Y
Gomollón, F
Calvet, X
García-Sepulcre, MF
Gutiérrez, A
Pérez-Calle, JL
Sierra-Ausín, M
Bermejo, F
Arias, L
Barreiro-de Acosta, M
Barrio, J
Lorente, R
Guardiola, J
Varela, P
Ponferrada-Díaz, A
Marín-Jiménez, I
Pascual, CM
Garcia-Planella, E
Domènech, E
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv pediatric
familial history
inflammatory bowel disease
surgery
biologicals
topic pediatric
familial history
inflammatory bowel disease
surgery
biologicals
description Background: Pediatric-onset familial inflammatory bowel disease (IBD) may differ from sporadic pediatric-onset IBD in its genetic and environmental background and may have distinct clinical and therapeutic implications. Objective: To evaluate the influence of a positive family history of IBD on the use of medical therapies and surgical interventions in adult patients with pediatric-onset IBD. Methods: Retrospective case-control study using the Spanish ENEIDA registry, including adults diagnosed with pediatric-onset IBD since 2006. Familial forms (FFs) (defined by a first-degree relative with IBD) and sporadic forms (SF) (with no relatives of any grade with IBD) were matched 1:4 by type of IBD, sex, age at IBD diagnosis, disease location, disease pattern, development of perianal disease and smoking status at diagnosis. The study outcomes were the use of immunomodulators, biological therapies, intestinal surgery, and perianal surgery during follow-up. Results: Six-hundred and fifty-five Crohn's disease (CD) (131 FF) and 440 ulcerative colitis (UC) (88 FF) patients were included. Immunomodulators, biological therapy, and intestinal surgery were used evenly among FF and SF patients for both UC and CD. However, a higher requirement for perianal surgery among FF-CD patients (18.3% vs. 10.5%, p = 0.014), together with a shorter time to perianal surgery (11 vs. 20 months, log-rank p = 0.004), was observed. Conclusions: Patients with FF of pediatric-onset IBD do not exhibit an increased use of immunomodulators, biological agents, or intestinal surgery, but do exhibit a higher need for perianal surgery, as compared to patients with SF pediatric-onset IBD.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19907
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19907
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Journal of Clinical Medicine
ISSN: 20770383
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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