Influence of familial inflammatory bowel disease history on the use of immunosuppressants, biological agents and surgery in patients with pediatric-onset of the disease in the era of biological therapies. Results from the ENEIDA registry

Background: Pediatric-onset familial inflammatory bowel disease (IBD) may differ from 60 sporadic pediatric-onset IBD in its genetic and environmental background and may have distinct 61 clinical and therapeutic implications. Objective: To evaluate the influence of a positive family his-62 tory of I...

Descripción completa

Detalles Bibliográficos
Autores: González Muñoza, Carlos|||0000-0003-0164-3449, Giordano, Antonio|||0000-0002-4982-2529, Ricart, Elena, Nos, Pilar|||0000-0002-6619-1511, Iglesias-Flores, Eva, P. Gisbert, Javier|||0000-0003-2090-3445, García-López, Santiago|||0000-0003-3970-5457, Mesonero, Francisco|||0000-0002-7864-8187, Pascual, Isabel, Tardillo, Carlos, Rivero, Montserrat|||0000-0002-5834-1559, Riestra, Sabino|||0000-0002-9383-3698, Mañosa i Ciria, Míriam|||0000-0002-9051-2581, Zabana, Yamile|||0000-0003-4023-8868, Gomollón, Fernando|||0000-0003-0076-3529, Calvet, Xavier|||0000-0002-6278-9663, García-Sepulcre, Mariana Fe|||0000-0002-1329-9529, Gutiérrez Casbas, Ana|||0000-0002-5460-4139, Pérez-Calle, José Lázaro|||0000-0002-8724-2760, Sierra Ausín, Mónica|||0000-0003-3342-8209, Bermejo, Fernando|||0000-0003-4610-0886, Arias García, Lara, Barreiro de-Acosta, Manuel|||0000-0001-5915-1477, Barrio, Jesús|||0000-0001-7087-3921, Lorente Poyatos, Rufo|||0000-0003-0709-2932, Guardiola, Jordi|||0000-0002-0464-241X, Varela, Pilar|||0000-0003-1737-3236, Ponferrada Díaz, Ángel|||0000-0002-1176-276X, Marín Jiménez, Ignacio|||0000-0001-5424-2484, Martínez Pascual, Cristina, García-Planella, Esther|||0000-0002-4325-0697, Domènech, Eugeni|||0000-0002-2315-7196
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:311162
Acceso en línea:https://ddd.uab.cat/record/311162
https://dx.doi.org/urn:doi:10.3390/jcm14103352
Access Level:acceso abierto
Palabra clave:Pediatric
Familial history
Inflammatory bowel disease
Surgery
Biologicals
Descripción
Sumario:Background: Pediatric-onset familial inflammatory bowel disease (IBD) may differ from 60 sporadic pediatric-onset IBD in its genetic and environmental background and may have distinct 61 clinical and therapeutic implications. Objective: To evaluate the influence of a positive family his-62 tory of IBD on the use of medical therapies and surgical interventions in adult patients with pediat-63 ric-onset IBD. Methods: Retrospective case-control study using the Spanish ENEIDA registry, in-64 cluding adults diagnosed with pediatric-onset IBD since 2006. Familial forms (FF) (defined by a first-65 degree relative with IBD) and sporadic forms (SF) (with no relatives of any grade with IBD) were 66 matched 1:4 by type of IBD, sex, age at IBD diagnosis, disease location, disease pattern, development 67 of perianal disease and smoking status at diagnosis. The study outcomes were the use of immuno-68 modulators, biological therapies, intestinal surgery, and perianal surgery during follow-up. Re-69 sults: Six-hundred and fifty-five Crohn's disease (CD) (131 FF) and 440 ulcerative colitis (UC)(88 FF) 70 patients were included. Immunomodulators, biological therapy and intestinal surgery were used 71 evenly among FF and SF patients for both UC and CD. However, a higher requirement for perianal 72 surgery among FF-CD patients (18.3% vs. 10.5%, p=0.014), together with a shorter time to perianal 73 surgery (11 vs. 20 months, log rank p = 0.004), was observed. Conclusion: Patients with FF of pedi-74 atric-onset IBD do not exhibit an increased use of immunomodulators, biological agents nor intesti-75 nal surgery, but do exhibit a higher need for perianal surgery, as compared to patients with SF 76 pediatric-onset IBD.

Similares en LA Referencia