A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series
Background: Budesonide and tixocortol pivalate as markers of contact allergy to corticosteroids have been questioned, as they are not able to detect a significant percentage of allergic patients. Objectives: To investigate the potential role of clobetasol propionate in enhancing corticosteroid sensi...
| Autores: | , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:311600 |
| Acceso en línea: | https://ddd.uab.cat/record/311600 https://dx.doi.org/urn:doi:10.1111/cod.14639 |
| Access Level: | acceso abierto |
| Palabra clave: | Budesonide Clobetasol propionate Contact dermatitis Tixocortol pivalate |
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A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline seriesClobetasol propionate in the spotlightMercader-García, Pedro|||0000-0002-8309-9725Silvestre Salvador, Juan Francisco|||0000-0002-8532-6338Navarro-Triviño, Francisco José|||0000-0002-5454-3671Giménez-Arnau, Ana M.|||0000-0001-5434-7753Pastor-Nieto, María Antonia|||0000-0001-8382-5419Córdoba-Guijarro, Susana|||0000-0002-1809-4821Melé Ninot, Gemma|||0000-0003-0365-0634Tous Romero, Fátima|||0000-0002-3904-3396González Pérez, Ricardo|||0000-0001-5238-215XRuiz González, Inmaculada|||0000-0002-5101-466XSánchez-Pérez, JavierGatica-Ortega, María Elena|||0000-0002-8203-5834Sánchez-Pedreño, Paloma|||0000-0002-4974-4583Miquel Miquel, Francisco Javier|||0000-0002-1780-4481Ortiz-Frutos, FJ.|||0000-0002-0635-0971Carrascosa, José Manuel|||0000-0003-4266-0771Serra Baldrich, Esther|||0000-0001-7603-0300Sanz-Sánchez, Tatiana|||0000-0002-5796-7680Soria-Aledo, V.|||0000-0003-0159-4034Carrillo, Andres|||0000-0002-1937-6855Borrego, Leopoldo|||0000-0002-0199-2756BudesonideClobetasol propionateContact dermatitisTixocortol pivalateBackground: Budesonide and tixocortol pivalate as markers of contact allergy to corticosteroids have been questioned, as they are not able to detect a significant percentage of allergic patients. Objectives: To investigate the potential role of clobetasol propionate in enhancing corticosteroid sensitisation detection. Methods: Between January 2022 and December 2023, patients who attended centres involved in the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy were tested with an extended baseline series that included budesonide, tixocortol pivalate, clobetasol propionate 0.1% in ethanol and 1% in petrolatum. Results: A total of 4338 patients were tested. Twenty-four patients were allergic to budesonide (0.55%, 95% CI: 0.37-0.82); nine patients were allergic to tixocortol pivalate (0.21%, 95% CI: 0.11-0.39); and 23 patients were allergic to clobetasol (0.53%, 95% CI: 0.35-0.79). Only four of those patients allergic to clobetasol were detected by budesonide and one by tixocortol pivalate. No significant differences in the number of positive tests were found between clobetasol in petrolatum or ethanol. Conclusions: In Spain budesonide remains the main corticosteroid allergy marker whereas the role of tixocortol pivalate is questionable. The addition of clobetasol propionate to the Spanish baseline series would improve the ability to detect patients allergic to corticosteroids. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/311600https://dx.doi.org/urn:doi:10.1111/cod.14639reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3116002026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series Clobetasol propionate in the spotlight |
| title |
A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series |
| spellingShingle |
A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series Mercader-García, Pedro|||0000-0002-8309-9725 Budesonide Clobetasol propionate Contact dermatitis Tixocortol pivalate |
| title_short |
A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series |
| title_full |
A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series |
| title_fullStr |
A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series |
| title_full_unstemmed |
A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series |
| title_sort |
A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series |
| dc.creator.none.fl_str_mv |
Mercader-García, Pedro|||0000-0002-8309-9725 Silvestre Salvador, Juan Francisco|||0000-0002-8532-6338 Navarro-Triviño, Francisco José|||0000-0002-5454-3671 Giménez-Arnau, Ana M.|||0000-0001-5434-7753 Pastor-Nieto, María Antonia|||0000-0001-8382-5419 Córdoba-Guijarro, Susana|||0000-0002-1809-4821 Melé Ninot, Gemma|||0000-0003-0365-0634 Tous Romero, Fátima|||0000-0002-3904-3396 González Pérez, Ricardo|||0000-0001-5238-215X Ruiz González, Inmaculada|||0000-0002-5101-466X Sánchez-Pérez, Javier Gatica-Ortega, María Elena|||0000-0002-8203-5834 Sánchez-Pedreño, Paloma|||0000-0002-4974-4583 Miquel Miquel, Francisco Javier|||0000-0002-1780-4481 Ortiz-Frutos, FJ.|||0000-0002-0635-0971 Carrascosa, José Manuel|||0000-0003-4266-0771 Serra Baldrich, Esther|||0000-0001-7603-0300 Sanz-Sánchez, Tatiana|||0000-0002-5796-7680 Soria-Aledo, V.|||0000-0003-0159-4034 Carrillo, Andres|||0000-0002-1937-6855 Borrego, Leopoldo|||0000-0002-0199-2756 |
| author |
Mercader-García, Pedro|||0000-0002-8309-9725 |
| author_facet |
Mercader-García, Pedro|||0000-0002-8309-9725 Silvestre Salvador, Juan Francisco|||0000-0002-8532-6338 Navarro-Triviño, Francisco José|||0000-0002-5454-3671 Giménez-Arnau, Ana M.|||0000-0001-5434-7753 Pastor-Nieto, María Antonia|||0000-0001-8382-5419 Córdoba-Guijarro, Susana|||0000-0002-1809-4821 Melé Ninot, Gemma|||0000-0003-0365-0634 Tous Romero, Fátima|||0000-0002-3904-3396 González Pérez, Ricardo|||0000-0001-5238-215X Ruiz González, Inmaculada|||0000-0002-5101-466X Sánchez-Pérez, Javier Gatica-Ortega, María Elena|||0000-0002-8203-5834 Sánchez-Pedreño, Paloma|||0000-0002-4974-4583 Miquel Miquel, Francisco Javier|||0000-0002-1780-4481 Ortiz-Frutos, FJ.|||0000-0002-0635-0971 Carrascosa, José Manuel|||0000-0003-4266-0771 Serra Baldrich, Esther|||0000-0001-7603-0300 Sanz-Sánchez, Tatiana|||0000-0002-5796-7680 Soria-Aledo, V.|||0000-0003-0159-4034 Carrillo, Andres|||0000-0002-1937-6855 Borrego, Leopoldo|||0000-0002-0199-2756 |
| author_role |
author |
| author2 |
Silvestre Salvador, Juan Francisco|||0000-0002-8532-6338 Navarro-Triviño, Francisco José|||0000-0002-5454-3671 Giménez-Arnau, Ana M.|||0000-0001-5434-7753 Pastor-Nieto, María Antonia|||0000-0001-8382-5419 Córdoba-Guijarro, Susana|||0000-0002-1809-4821 Melé Ninot, Gemma|||0000-0003-0365-0634 Tous Romero, Fátima|||0000-0002-3904-3396 González Pérez, Ricardo|||0000-0001-5238-215X Ruiz González, Inmaculada|||0000-0002-5101-466X Sánchez-Pérez, Javier Gatica-Ortega, María Elena|||0000-0002-8203-5834 Sánchez-Pedreño, Paloma|||0000-0002-4974-4583 Miquel Miquel, Francisco Javier|||0000-0002-1780-4481 Ortiz-Frutos, FJ.|||0000-0002-0635-0971 Carrascosa, José Manuel|||0000-0003-4266-0771 Serra Baldrich, Esther|||0000-0001-7603-0300 Sanz-Sánchez, Tatiana|||0000-0002-5796-7680 Soria-Aledo, V.|||0000-0003-0159-4034 Carrillo, Andres|||0000-0002-1937-6855 Borrego, Leopoldo|||0000-0002-0199-2756 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Budesonide Clobetasol propionate Contact dermatitis Tixocortol pivalate |
| topic |
Budesonide Clobetasol propionate Contact dermatitis Tixocortol pivalate |
| description |
Background: Budesonide and tixocortol pivalate as markers of contact allergy to corticosteroids have been questioned, as they are not able to detect a significant percentage of allergic patients. Objectives: To investigate the potential role of clobetasol propionate in enhancing corticosteroid sensitisation detection. Methods: Between January 2022 and December 2023, patients who attended centres involved in the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy were tested with an extended baseline series that included budesonide, tixocortol pivalate, clobetasol propionate 0.1% in ethanol and 1% in petrolatum. Results: A total of 4338 patients were tested. Twenty-four patients were allergic to budesonide (0.55%, 95% CI: 0.37-0.82); nine patients were allergic to tixocortol pivalate (0.21%, 95% CI: 0.11-0.39); and 23 patients were allergic to clobetasol (0.53%, 95% CI: 0.35-0.79). Only four of those patients allergic to clobetasol were detected by budesonide and one by tixocortol pivalate. No significant differences in the number of positive tests were found between clobetasol in petrolatum or ethanol. Conclusions: In Spain budesonide remains the main corticosteroid allergy marker whereas the role of tixocortol pivalate is questionable. The addition of clobetasol propionate to the Spanish baseline series would improve the ability to detect patients allergic to corticosteroids. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2 2024-01-01 2024 2024-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/311600 https://dx.doi.org/urn:doi:10.1111/cod.14639 |
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https://ddd.uab.cat/record/311600 https://dx.doi.org/urn:doi:10.1111/cod.14639 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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