A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series

Background: Budesonide and tixocortol pivalate as markers of contact allergy to corticosteroids have been questioned, as they are not able to detect a significant percentage of allergic patients. Objectives: To investigate the potential role of clobetasol propionate in enhancing corticosteroid sensi...

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Detalles Bibliográficos
Autores: Mercader-García, Pedro|||0000-0002-8309-9725, Silvestre Salvador, Juan Francisco|||0000-0002-8532-6338, Navarro-Triviño, Francisco José|||0000-0002-5454-3671, Giménez-Arnau, Ana M.|||0000-0001-5434-7753, Pastor-Nieto, María Antonia|||0000-0001-8382-5419, Córdoba-Guijarro, Susana|||0000-0002-1809-4821, Melé Ninot, Gemma|||0000-0003-0365-0634, Tous Romero, Fátima|||0000-0002-3904-3396, González Pérez, Ricardo|||0000-0001-5238-215X, Ruiz González, Inmaculada|||0000-0002-5101-466X, Sánchez-Pérez, Javier, Gatica-Ortega, María Elena|||0000-0002-8203-5834, Sánchez-Pedreño, Paloma|||0000-0002-4974-4583, Miquel Miquel, Francisco Javier|||0000-0002-1780-4481, Ortiz-Frutos, FJ.|||0000-0002-0635-0971, Carrascosa, José Manuel|||0000-0003-4266-0771, Serra Baldrich, Esther|||0000-0001-7603-0300, Sanz-Sánchez, Tatiana|||0000-0002-5796-7680, Soria-Aledo, V.|||0000-0003-0159-4034, Carrillo, Andres|||0000-0002-1937-6855, Borrego, Leopoldo|||0000-0002-0199-2756
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:311600
Acceso en línea:https://ddd.uab.cat/record/311600
https://dx.doi.org/urn:doi:10.1111/cod.14639
Access Level:acceso abierto
Palabra clave:Budesonide
Clobetasol propionate
Contact dermatitis
Tixocortol pivalate
Descripción
Sumario:Background: Budesonide and tixocortol pivalate as markers of contact allergy to corticosteroids have been questioned, as they are not able to detect a significant percentage of allergic patients. Objectives: To investigate the potential role of clobetasol propionate in enhancing corticosteroid sensitisation detection. Methods: Between January 2022 and December 2023, patients who attended centres involved in the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy were tested with an extended baseline series that included budesonide, tixocortol pivalate, clobetasol propionate 0.1% in ethanol and 1% in petrolatum. Results: A total of 4338 patients were tested. Twenty-four patients were allergic to budesonide (0.55%, 95% CI: 0.37-0.82); nine patients were allergic to tixocortol pivalate (0.21%, 95% CI: 0.11-0.39); and 23 patients were allergic to clobetasol (0.53%, 95% CI: 0.35-0.79). Only four of those patients allergic to clobetasol were detected by budesonide and one by tixocortol pivalate. No significant differences in the number of positive tests were found between clobetasol in petrolatum or ethanol. Conclusions: In Spain budesonide remains the main corticosteroid allergy marker whereas the role of tixocortol pivalate is questionable. The addition of clobetasol propionate to the Spanish baseline series would improve the ability to detect patients allergic to corticosteroids.

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