Novel Water‐Soluble Carbosilane Dendrimers: Synthesis and Biocompatibility

[EN] A synthetic strategy has been developed for the preparation of new peripheral amine- or ammonium-terminated carbosilane dendrimers of type nG-[Si(OCH2CH2NMe2)y]x or nG-[Si(OCH2CH2NMe3+I–)y]x, respectively. It consists of the alcoholysis of well-known chlorosilane-terminated dendrimers with N,N-...

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Detalles Bibliográficos
Autores: Ortega, Paula, Bermejo Martín, Jesús Francisco, Chonco, Louis, de Jesus, Ernesto, de la Mata, F. Javier, Fernández, Gerónimo, Flores, Juan Carlos, Gómez, Rafael, Serramía, M. Jesús, Muñoz‐Fernandez, M. Angeles
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2006
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/161068
Acceso en línea:http://hdl.handle.net/10366/161068
Access Level:acceso abierto
Palabra clave:Bioinorganic chemistry
Dendrimers
Silicon
Drug delivery
Toxicity
Descripción
Sumario:[EN] A synthetic strategy has been developed for the preparation of new peripheral amine- or ammonium-terminated carbosilane dendrimers of type nG-[Si(OCH2CH2NMe2)y]x or nG-[Si(OCH2CH2NMe3+I–)y]x, respectively. It consists of the alcoholysis of well-known chlorosilane-terminated dendrimers with N,N-dimethylethanolamine and the subsequent quaternization with MeI. All these systems are susceptible to hydrolysis, although the decomposition depends on concentration and dendrimer generation. Evaluation of dendrimer toxicities by phase-contrast light microscopy and MTT assay were carried out, and evidence of dendrimer/oligonucleotide complex formation was carried out by gel electrophoresis

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