Synthesis of Florbetapir aza-analogues using chemistry of pyridinium N-aminides

Neuroimaging of β-amyloid (Aβ) plaques in brain, employing Positron Emission Tomography (PET) has enabled early diagnosis of Alzheimer’s Disease and, although different 18F radiolabeled markers as Florbetapir and Florbetaben are already in the market, new molecules with better affinity and selectivi...

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Autores: Gala, Elena, Recio, Javier, Álvarez-Builla, Julio, Izquierdo, M.Luisa
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Rey Juan Carlos
Repositorio:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
OAI Identifier:oai:burjcdigital.urjc.es:10115/29382
Acceso en línea:https://hdl.handle.net/10115/29382
Access Level:acceso abierto
Palabra clave:Pyridinium N-aminides
florbetapir
heterocycles
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spelling Synthesis of Florbetapir aza-analogues using chemistry of pyridinium N-aminidesGala, ElenaRecio, JavierÁlvarez-Builla, JulioIzquierdo, M.LuisaPyridinium N-aminidesflorbetapirheterocyclesNeuroimaging of β-amyloid (Aβ) plaques in brain, employing Positron Emission Tomography (PET) has enabled early diagnosis of Alzheimer’s Disease and, although different 18F radiolabeled markers as Florbetapir and Florbetaben are already in the market, new molecules with better affinity and selectivity to Aβ plaques should be explored. In this article, two aza-analogues of Florbetapir have been synthesized from Pyridinium N-aminides. The new aza-analogues were prepared following straightforward synthetic routes under mild conditions. Although the products have been obtained using stable 19F, the methods are compatible with the future use of 18F, to generate products to be tested in the development of new PET reagents.ARKAT USA202420242021info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10115/29382reponame:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlosinstname:Universidad Rey Juan CarlosInglésAttribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:burjcdigital.urjc.es:10115/293822026-06-24T12:48:17Z
dc.title.none.fl_str_mv Synthesis of Florbetapir aza-analogues using chemistry of pyridinium N-aminides
title Synthesis of Florbetapir aza-analogues using chemistry of pyridinium N-aminides
spellingShingle Synthesis of Florbetapir aza-analogues using chemistry of pyridinium N-aminides
Gala, Elena
Pyridinium N-aminides
florbetapir
heterocycles
title_short Synthesis of Florbetapir aza-analogues using chemistry of pyridinium N-aminides
title_full Synthesis of Florbetapir aza-analogues using chemistry of pyridinium N-aminides
title_fullStr Synthesis of Florbetapir aza-analogues using chemistry of pyridinium N-aminides
title_full_unstemmed Synthesis of Florbetapir aza-analogues using chemistry of pyridinium N-aminides
title_sort Synthesis of Florbetapir aza-analogues using chemistry of pyridinium N-aminides
dc.creator.none.fl_str_mv Gala, Elena
Recio, Javier
Álvarez-Builla, Julio
Izquierdo, M.Luisa
author Gala, Elena
author_facet Gala, Elena
Recio, Javier
Álvarez-Builla, Julio
Izquierdo, M.Luisa
author_role author
author2 Recio, Javier
Álvarez-Builla, Julio
Izquierdo, M.Luisa
author2_role author
author
author
dc.subject.none.fl_str_mv Pyridinium N-aminides
florbetapir
heterocycles
topic Pyridinium N-aminides
florbetapir
heterocycles
description Neuroimaging of β-amyloid (Aβ) plaques in brain, employing Positron Emission Tomography (PET) has enabled early diagnosis of Alzheimer’s Disease and, although different 18F radiolabeled markers as Florbetapir and Florbetaben are already in the market, new molecules with better affinity and selectivity to Aβ plaques should be explored. In this article, two aza-analogues of Florbetapir have been synthesized from Pyridinium N-aminides. The new aza-analogues were prepared following straightforward synthetic routes under mild conditions. Although the products have been obtained using stable 19F, the methods are compatible with the future use of 18F, to generate products to be tested in the development of new PET reagents.
publishDate 2021
dc.date.none.fl_str_mv 2021
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10115/29382
url https://hdl.handle.net/10115/29382
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ARKAT USA
publisher.none.fl_str_mv ARKAT USA
dc.source.none.fl_str_mv reponame:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
instname:Universidad Rey Juan Carlos
instname_str Universidad Rey Juan Carlos
reponame_str BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
collection BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411619160719360
score 15,811543

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