In vivo and in vitro biocompatible alginate film crosslinked with Ca2+ and Co2+ manifests antiviral, antibacterial and anticancer activity
[EN] Alginate crosslinked with calcium cations is a promising hydrogel for biomedical applications as it is non-toxic, has suitable mechanical properties and is insoluble in water. Cobalt has been shown to possess antibacterial capacity against Gram-positive and Gram-negative bacteria, and has an an...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/209931 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/209931 |
| Access Level: | acceso abierto |
| Palabra clave: | Alginate Cobalt Toxicity Antiviral Antibacterial Anticancer INGENIERIA ELECTRICA |
| Sumario: | [EN] Alginate crosslinked with calcium cations is a promising hydrogel for biomedical applications as it is non-toxic, has suitable mechanical properties and is insoluble in water. Cobalt has been shown to possess antibacterial capacity against Gram-positive and Gram-negative bacteria, and has an angiogenesis effect. In this study, alginate films were crosslinked with Ca2+ and Co2+ ions to explore their biological properties in terms of antiviral capacity, antibacterial properties, anticancer activity and their toxicity. The results show that the hydrogel with a very small amount of cobalt was biocompatible in vivo using the Caenorhabditis elegans model and in vitro on human keratinocyte cells and it also exhibited antibacterial activity against the life-threatening methicillinresistant Staphylococcus aureus. Furthermore, this hydrogel showed antiviral activity against a surrogate of SARSCoV-2 and anticancer properties against melanoma and colon cancer cells, which render it a promising material for biomedical applications such as wound healing and tissue engineering. Water sorption experiments, Fourier transform infrared spectroscopy, electron microscopy with Energy Dispersive X-ray Spectrometry and degradation analysis in acid aqueous medium were performed to complete the characterization of these new materials. |
|---|