Five-year follow-up mortality prognostic index for colorectal patients

Purpose To identify 5-year survival prognostic variables in patients with colorectal cancer (CRC) and to propose a survival prognostic score that also takes into account changes over time in the patient’s health-related quality of life (HRQoL) status. Methods Prospective observational cohort study o...

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Autores: Orive Calzada, Miren, Barrio Beraza, Irantzu, Lázaro Aramburu, Santiago, González, Nerea, Baré Mañas, Marisa, Fernández de Larrea, Nerea, Redondo, Maximino, Cortajarena, Sarai, Bilbao, Amaia, Aguirre, Urko, Sarasqueta Eizaguirre, Cristina, Quintana López, José María, REDISSEC-CARESS CCR Group
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/61057
Acceso en línea:http://hdl.handle.net/10810/61057
Access Level:acceso abierto
Palabra clave:colorectal cancer
patient-reported outcome measures
health-related quality of life
cohort studies
survival models
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repository_id_str
dc.title.none.fl_str_mv Five-year follow-up mortality prognostic index for colorectal patients
title Five-year follow-up mortality prognostic index for colorectal patients
spellingShingle Five-year follow-up mortality prognostic index for colorectal patients
Orive Calzada, Miren
colorectal cancer
patient-reported outcome measures
health-related quality of life
cohort studies
survival models
title_short Five-year follow-up mortality prognostic index for colorectal patients
title_full Five-year follow-up mortality prognostic index for colorectal patients
title_fullStr Five-year follow-up mortality prognostic index for colorectal patients
title_full_unstemmed Five-year follow-up mortality prognostic index for colorectal patients
title_sort Five-year follow-up mortality prognostic index for colorectal patients
dc.creator.none.fl_str_mv Orive Calzada, Miren
Barrio Beraza, Irantzu
Lázaro Aramburu, Santiago
González, Nerea
Baré Mañas, Marisa
Fernández de Larrea, Nerea
Redondo, Maximino
Cortajarena, Sarai
Bilbao, Amaia
Aguirre, Urko
Sarasqueta Eizaguirre, Cristina
Quintana López, José María
REDISSEC-CARESS CCR Group
author Orive Calzada, Miren
author_facet Orive Calzada, Miren
Barrio Beraza, Irantzu
Lázaro Aramburu, Santiago
González, Nerea
Baré Mañas, Marisa
Fernández de Larrea, Nerea
Redondo, Maximino
Cortajarena, Sarai
Bilbao, Amaia
Aguirre, Urko
Sarasqueta Eizaguirre, Cristina
Quintana López, José María
REDISSEC-CARESS CCR Group
author_role author
author2 Barrio Beraza, Irantzu
Lázaro Aramburu, Santiago
González, Nerea
Baré Mañas, Marisa
Fernández de Larrea, Nerea
Redondo, Maximino
Cortajarena, Sarai
Bilbao, Amaia
Aguirre, Urko
Sarasqueta Eizaguirre, Cristina
Quintana López, José María
REDISSEC-CARESS CCR Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv colorectal cancer
patient-reported outcome measures
health-related quality of life
cohort studies
survival models
topic colorectal cancer
patient-reported outcome measures
health-related quality of life
cohort studies
survival models
description Purpose To identify 5-year survival prognostic variables in patients with colorectal cancer (CRC) and to propose a survival prognostic score that also takes into account changes over time in the patient’s health-related quality of life (HRQoL) status. Methods Prospective observational cohort study of CRC patients. We collected data from their diagnosis, intervention, and at 1, 2, 3, and 5 years following the index intervention, also collecting HRQoL data using the EuroQol-5D-5L (EQ-5D-5L), European Organization for Research and Treatment of Cancer’s Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Multivariate Cox proportional models were used. Results We found predictors of mortality over the 5-year follow-up to be being older; being male; having a higher TNM stage; having a higher lymph node ratio; having a result of CRC surgery classified as R1 or R2; invasion of neighboring organs; having a higher score on the Charlson comorbidity index; having an ASA IV; and having worse scores, worse quality of life, on the EORTC and EQ-5D questionnaires, as compared to those with higher scores in each of those questionnaires respectively. Conclusions These results allow preventive and controlling measures to be established on long-term follow-up of these patients, based on a few easily measurable variables.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/61057
url http://hdl.handle.net/10810/61057
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN/PID2020-115738 GB-I00/
https://link.springer.com/article/10.1007/s00384-023-04358-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Five-year follow-up mortality prognostic index for colorectal patientsOrive Calzada, MirenBarrio Beraza, IrantzuLázaro Aramburu, SantiagoGonzález, NereaBaré Mañas, MarisaFernández de Larrea, NereaRedondo, MaximinoCortajarena, SaraiBilbao, AmaiaAguirre, UrkoSarasqueta Eizaguirre, CristinaQuintana López, José MaríaREDISSEC-CARESS CCR Groupcolorectal cancerpatient-reported outcome measureshealth-related quality of lifecohort studiessurvival modelsPurpose To identify 5-year survival prognostic variables in patients with colorectal cancer (CRC) and to propose a survival prognostic score that also takes into account changes over time in the patient’s health-related quality of life (HRQoL) status. Methods Prospective observational cohort study of CRC patients. We collected data from their diagnosis, intervention, and at 1, 2, 3, and 5 years following the index intervention, also collecting HRQoL data using the EuroQol-5D-5L (EQ-5D-5L), European Organization for Research and Treatment of Cancer’s Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Multivariate Cox proportional models were used. Results We found predictors of mortality over the 5-year follow-up to be being older; being male; having a higher TNM stage; having a higher lymph node ratio; having a result of CRC surgery classified as R1 or R2; invasion of neighboring organs; having a higher score on the Charlson comorbidity index; having an ASA IV; and having worse scores, worse quality of life, on the EORTC and EQ-5D questionnaires, as compared to those with higher scores in each of those questionnaires respectively. Conclusions These results allow preventive and controlling measures to be established on long-term follow-up of these patients, based on a few easily measurable variables.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported in part by grants from the Instituto de Salud Carlos III and the European Regional Development Fund (PS09/00314, PS09/00910, PS09/00746, PS09/00805, PI09/90460, PI09/90490, PI09/90453, PI09/90441, PI09/90397); the Spanish Ministry of the Economy (PID2020-115738 GB-I00); the Departments of Health (2010111098) and Education, Language Policy and Culture (IT1456-22; IT1598-22; IT-1187–19) of the Basque Government; the Research Committee of Galdakao Hospital; the REDISSEC (Red de Investigación en Servicios de Salud en Enfermedades Crónicas) thematic network of the Instituto de Salud Carlos III; and the Department of Education of the Basque Government through the Consolidated Research Group MATHMODE (IT1456-22) and the Basque Government through BMTF “Mathematical Modeling Applied to Health” Project. This study has been funded by Instituto de Salud Carlos III (ISCIII) through the projects "RD16/0001/0001" and RD21CIII/0003/0017 and co-funded by the European Union.Springer202320232023info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/61057reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MICINN/PID2020-115738 GB-I00/https://link.springer.com/article/10.1007/s00384-023-04358-0info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Atribución 3.0 Españaoai:addi.ehu.eus:10810/610572026-06-18T09:23:17Z
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