Five-year follow-up mortality prognostic index for colorectal patients

Purpose To identify 5-year survival prognostic variables in patients with colorectal cancer (CRC) and to propose a survival prognostic score that also takes into account changes over time in the patient’s health-related quality of life (HRQoL) status. Methods Prospective observational cohort study o...

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Detalles Bibliográficos
Autores: Orive Calzada, Miren, Barrio Beraza, Irantzu, Lázaro Aramburu, Santiago, González, Nerea, Baré Mañas, Marisa, Fernández de Larrea, Nerea, Redondo, Maximino, Cortajarena, Sarai, Bilbao, Amaia, Aguirre, Urko, Sarasqueta Eizaguirre, Cristina, Quintana López, José María, REDISSEC-CARESS CCR Group
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/61057
Acceso en línea:http://hdl.handle.net/10810/61057
Access Level:acceso abierto
Palabra clave:colorectal cancer
patient-reported outcome measures
health-related quality of life
cohort studies
survival models
Descripción
Sumario:Purpose To identify 5-year survival prognostic variables in patients with colorectal cancer (CRC) and to propose a survival prognostic score that also takes into account changes over time in the patient’s health-related quality of life (HRQoL) status. Methods Prospective observational cohort study of CRC patients. We collected data from their diagnosis, intervention, and at 1, 2, 3, and 5 years following the index intervention, also collecting HRQoL data using the EuroQol-5D-5L (EQ-5D-5L), European Organization for Research and Treatment of Cancer’s Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Multivariate Cox proportional models were used. Results We found predictors of mortality over the 5-year follow-up to be being older; being male; having a higher TNM stage; having a higher lymph node ratio; having a result of CRC surgery classified as R1 or R2; invasion of neighboring organs; having a higher score on the Charlson comorbidity index; having an ASA IV; and having worse scores, worse quality of life, on the EORTC and EQ-5D questionnaires, as compared to those with higher scores in each of those questionnaires respectively. Conclusions These results allow preventive and controlling measures to be established on long-term follow-up of these patients, based on a few easily measurable variables.

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