Aggressive or moderate fluid resuscitation in acute pancreatitis

BACKGROUND: Early aggressive hydration is widely recommended for the management of acute pancreatitis, but evidence for this practice is limited. METHODS: At 18 centers, we randomly assigned patients who presented with acute pancreatitis to receive goal-directed aggressive or moderate resuscitation...

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Detalles Bibliográficos
Autores: Madaria, Enrique de, Buxbaum, James L., Maisonneuve, Patrick, García García de Paredes, Ana, Zapater, Pedro, Guilabert, Lucía, Vaillo-Rocamora, Alicia, Rodríguez-Gandía, Miguel Á., Donate-Ortega, Jesús, Lozada-Hernández, Edgard E., Collazo Moreno, Alan J.R., Lira-Aguilar, Alba, Llovet, Laura P., Mehta, Rajiv, Tandel, Raj, Navarro, Pablo, Sánchez-Pardo, Ana M., Sánchez-Marin, Claudia, Cobreros, Marina, Fernández-Cabrera, Idaira, Casals-Seoane, Fernando, Casas Deza, Diego, Lauret-Braña, Eugenia, Martí-Marqués, Eva, Camacho-Montaño, Laura M., Ubieto, Verónica, Ganuza, Mikel, Bolado Concejo, Federico, ERICA Consortium
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/48332
Acceso en línea:https://hdl.handle.net/2454/48332
Access Level:acceso abierto
Palabra clave:Fluid resuscitation
Acute pancreatitis
Descripción
Sumario:BACKGROUND: Early aggressive hydration is widely recommended for the management of acute pancreatitis, but evidence for this practice is limited. METHODS: At 18 centers, we randomly assigned patients who presented with acute pancreatitis to receive goal-directed aggressive or moderate resuscitation with lactated Ringer’s solution. Aggressive fluid resuscitation consisted of a bolus of 20 ml per kilogram of body weight, followed by 3 ml per kilogram per hour. Moderate fluid resuscitation consisted of a bolus of 10 ml per kilogram in patients with hypovolemia or no bolus in patients with normovolemia, followed by 1.5 ml per kilogram per hour in all patients in this group. Patients were assessed at 12, 24, 48, and 72 hours, and fluid resuscitation was adjusted according to the patient’s clinical status. The primary outcome was the development of moderately severe or severe pancreatitis during the hospitalization. The main safety outcome was fluid overload. The planned sample size was 744, with a first planned interim analysis after the enrollment of 248 patients. RESULTS: A total of 249 patients were included in the interim analysis. The trial was halted owing to between-group differences in the safety outcomes without a significant difference in the incidence of moderately severe or severe pancreatitis (22.1% in the aggressive-resuscitation group and 17.3% in the moderate-resuscitation group; adjusted relative risk, 1.30; 95% confidence interval [CI], 0.78 to 2.18; P=0.32). Fluid overload developed in 20.5% of the patients who received aggressive resuscitation and in 6.3% of those who received moderate resuscitation (adjusted relative risk, 2.85; 95% CI, 1.36 to 5.94, P=0.004). The median duration of hospitalization was 6 days (interquartile range, 4 to 8) in the aggressive-resuscitation group and 5 days (interquartile range, 3 to 7) in the moderate-resuscitation group. CONCLUSIONS: In this randomized trial involving patients with acute pancreatitis, early aggressive fluid resuscitation resulted in a higher incidence of fluid overload without improvement in clinical outcomes.

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