Fluid resuscitation with lactated Ringer's solution vs normal saline in acute pancreatitis: A triple-blind, randomized, controlled trial

Background: Little is known regarding the optimal type of fluid resuscitation in acute pancreatitis (AP). Objective: The objective of this article was to compare the effect of lactated Ringer's solution (LR) vs normal saline (NS) in the inflammatory response in AP. Methods: We conducted a tripl...

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Bibliographic Details
Authors: de-Madaria, Enrique, Herrera-Marante, Ivan, Gonzalez-Camacho, Veronica, Bonjoch, Laia, Quesada-Vazquez, Noe, Almenta-Saavedra, Isabel, Miralles-Macia, Cayetano, Acevedo-Piedra, Nelly G., Roger-Ibanez, Manuela, Sanchez-Marin, Claudia, Osuna-Ligero, Rosa, Gracia, Angel, Llorens, Pere, Zapater, Pedro, Singh, Vikesh K., Moreu-Martin, Rocio, Closa, Daniel
Format: article
Status:Published version
Publication Date:2018
Country:España
Institution:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repository:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p2966
Online Access:https://isabial.portalinvestigacion.com/publicaciones2966
Access Level:Open access
Keyword:Acute pancreatitis
fluid resuscitation
lactated Ringer's solution
randomized controlled trial
systemic inflammatory response syndrome/prevention and control
Description
Summary:Background: Little is known regarding the optimal type of fluid resuscitation in acute pancreatitis (AP). Objective: The objective of this article was to compare the effect of lactated Ringer's solution (LR) vs normal saline (NS) in the inflammatory response in AP. Methods: We conducted a triple-blind, randomized, controlled trial. Patients >= 18 admitted with AP were eligible. Patients were randomized to receive LR or NS. Primary outcome variables were number of systemic inflammatory response syndrome (SIRS) criteria at 24 hours, 48 hours and 72 hours and blood C-reactive protein (CRP) levels at 48 hours and 72 hours. Invitro complementary experiments were performed to further explore the interaction between pH, lactate and inflammation. Results: Nineteen patients receiving LR and 21 receiving NS were analyzed. The median (p25-p75) number of SIRS criteria at 48 hours were 1 (1-2) for NS vs 1 (0-1) for LR, p=0.060. CRP levels (mg/l) were as follows: at 48 hours NS 166 (78-281) vs LR 28 (3-124), p=0.037; at 72 hours NS 217 (59-323) vs LR 25 (3-169), p=0.043. Invitro, LR inhibited the induction of inflammatory phenotype of macrophages and NF-kappa B activation. This effect was not observed when using Ringer's solution without lactate, suggesting a direct anti-inflammatory effect of lactate. Conclusions: Lactated Ringer's is associated with an anti-inflammatory effect in patients with acute pancreatitis.

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