Antitumoral effect of Ocoxin, a natural compound-containing nutritional supplement, in small cell lung cancer
[EN]Lung cancer is the most frequently diagnosed neoplasia and represents the leading cause of cancer-related deaths worldwide. Due to this fact, efforts to improve patient survival through the introduction of novel therapies, as well as preventive actions, are urgently required. Considering this sc...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad de Salamanca (USAL) |
| Repositorio: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:dnet:gredos______::db34980ac48c170cbf2d121e2fd91b35 |
| Acceso en línea: | http://hdl.handle.net/10366/171329 |
| Access Level: | acceso abierto |
| Palabra clave: | cell lung cancer antioxidants cell cycle p27 apoptosis Antioxidants Zinc Sulfate Ascorbic Acid Drug Compounding Plant Extracts Xenograft Model Antitumor Assays Gene Expression Regulation Humans Vitamin B 6 Cell Line Cell Proliferation Folic Acid Proliferating Cell Nuclear Antigen Apoptosis Pantothenic Acid Vitamin B 12 Animals Small Cell Lung Carcinoma Mice 24 Ciencias de la Vida ácido pantoténico humanos ratones línea celular antígeno nuclear de proliferación celular vitamina B 6 extractos de plantas ácido fólico ensayos antitumorales por modelo de xenoinjerto regulación de la expresión génica carcinoma pulmonar de células pequeñas animales ácido ascórbico composición de medicamentos vitamina B 12 antioxidantes sulfato de zinc proliferación celular |
| Sumario: | [EN]Lung cancer is the most frequently diagnosed neoplasia and represents the leading cause of cancer-related deaths worldwide. Due to this fact, efforts to improve patient survival through the introduction of novel therapies, as well as preventive actions, are urgently required. Considering this scenario, the antitumoral action of the composite formulation Ocoxin® oral solution (OOS), that contains several antitumoral compounds including antioxidants, was tested in small cell lung cancer (SCLC) in vitro and in vivo preclinical models. OOS exhibited anti-SCLC action that was both time and dose dependent. In vivo OOS decreased the growth of tumors implanted in mice without showing signs of toxicity. The antitumoral effect was due to inhibition of cell proliferation and increased cell death. Genomic and biochemical analyses indicated that OOS augmented p27 and decreased the functioning of several routes involved in cell proliferation. In addition, OOS caused cell death by activation of caspases. Importantly, OOS favored the action of several standard of care drugs used in the SCLC clinic. Our results suggest that OOS has antitumoral action on SCLC, and could be used to supplement the action of drugs commonly used to treat this type of tumor. |
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