Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands

In this communication we report that anchoring avß3 or a5ß1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successfu...

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Autores: Fraioli, Roberta, Neubauer, Stefanie, Rechenmacher, Florian, Bosch Canals, Begoña María, Dashnyam, Khandmaa, Kim, Joong-Hyun, Gil Mur, Francisco Javier|||0000-0002-6824-1412, Ginebra Molins, Maria Pau|||0000-0002-4700-5621, Manero Planella, José María|||0000-0002-1673-4389, Mas Moruno, Carlos|||0000-0001-8337-0872
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/178261
Acceso en línea:https://hdl.handle.net/2117/178261
https://dx.doi.org/10.1039/c8bm01466c
Access Level:acceso abierto
Palabra clave:Biomedical materials
Materials biomèdics
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
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spelling Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligandsFraioli, RobertaNeubauer, StefanieRechenmacher, FlorianBosch Canals, Begoña MaríaDashnyam, KhandmaaKim, Joong-HyunGil Mur, Francisco Javier|||0000-0002-6824-1412Ginebra Molins, Maria Pau|||0000-0002-4700-5621Manero Planella, José María|||0000-0002-1673-4389Mas Moruno, Carlos|||0000-0001-8337-0872Biomedical materialsMaterials biomèdicsÀrees temàtiques de la UPC::Enginyeria biomèdica::BiomaterialsIn this communication we report that anchoring avß3 or a5ß1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.Peer ReviewedRoyal Society of Chemistry (RSC)20192019-04-0120202020-02-21journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/vnd.openxmlformats-officedocument.wordprocessingml.documenthttps://hdl.handle.net/2117/178261https://dx.doi.org/10.1039/c8bm01466creponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1782612026-05-27T15:37:01Z
dc.title.none.fl_str_mv Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands
title Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands
spellingShingle Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands
Fraioli, Roberta
Biomedical materials
Materials biomèdics
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
title_short Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands
title_full Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands
title_fullStr Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands
title_full_unstemmed Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands
title_sort Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands
dc.creator.none.fl_str_mv Fraioli, Roberta
Neubauer, Stefanie
Rechenmacher, Florian
Bosch Canals, Begoña María
Dashnyam, Khandmaa
Kim, Joong-Hyun
Gil Mur, Francisco Javier|||0000-0002-6824-1412
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Manero Planella, José María|||0000-0002-1673-4389
Mas Moruno, Carlos|||0000-0001-8337-0872
author Fraioli, Roberta
author_facet Fraioli, Roberta
Neubauer, Stefanie
Rechenmacher, Florian
Bosch Canals, Begoña María
Dashnyam, Khandmaa
Kim, Joong-Hyun
Gil Mur, Francisco Javier|||0000-0002-6824-1412
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Manero Planella, José María|||0000-0002-1673-4389
Mas Moruno, Carlos|||0000-0001-8337-0872
author_role author
author2 Neubauer, Stefanie
Rechenmacher, Florian
Bosch Canals, Begoña María
Dashnyam, Khandmaa
Kim, Joong-Hyun
Gil Mur, Francisco Javier|||0000-0002-6824-1412
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Manero Planella, José María|||0000-0002-1673-4389
Mas Moruno, Carlos|||0000-0001-8337-0872
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Biomedical materials
Materials biomèdics
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
topic Biomedical materials
Materials biomèdics
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
description In this communication we report that anchoring avß3 or a5ß1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-04-01
2020
2020-02-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/178261
https://dx.doi.org/10.1039/c8bm01466c
url https://hdl.handle.net/2117/178261
https://dx.doi.org/10.1039/c8bm01466c
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/vnd.openxmlformats-officedocument.wordprocessingml.document
dc.publisher.none.fl_str_mv Royal Society of Chemistry (RSC)
publisher.none.fl_str_mv Royal Society of Chemistry (RSC)
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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