Matings Between Individuals with Similar Major Histocompatibility Complex (MHC) Improve Offspring Survival in the Rainbow Trout (Oncorhynchus mykiss)

The major histocompatibility complex (MHC) consists of genes involved in immune response and molecular discrimination between self and non-self. MHC genes are the most polymorphic in vertebrates. The origin and maintenance of polymorphism in MHC genes in populations is still unresolved. Mechanisms s...

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Autores: Bergamino, Cinzia, Tomasoni, Mattia, Colussi, Silvia, Montemurro, Vittoria, Altinok, Ilhan, Prearo, Marino, Kotzamanidis, Charalampos, Acutis, Pier Luigi, Vela Alonso, Ana Isabel, Sciuto, Simona, Esposito, Giuseppe, Volpatti, Donatella, Bozzetta, Elena, Parati, Katia, Aidos, Lucia, Fariano, Lucio, Sicuro, Benedetto
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/112817
Acceso en línea:https://hdl.handle.net/20.500.14352/112817
Access Level:acceso abierto
Palabra clave:639.3
Similar haplotype
Offspring survival
Reproductive performance
Larvae deformity
Piscicultura
3105.02 Piscicultura
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oai_identifier_str oai:docta.ucm.es:20.500.14352/112817
network_acronym_str ES
network_name_str España
repository_id_str
spelling Matings Between Individuals with Similar Major Histocompatibility Complex (MHC) Improve Offspring Survival in the Rainbow Trout (Oncorhynchus mykiss)Bergamino, CinziaTomasoni, MattiaColussi, SilviaMontemurro, VittoriaAltinok, IlhanPrearo, MarinoKotzamanidis, CharalamposAcutis, Pier LuigiVela Alonso, Ana IsabelSciuto, SimonaEsposito, GiuseppeVolpatti, DonatellaBozzetta, ElenaParati, KatiaAidos, LuciaFariano, LucioSicuro, Benedetto639.3Similar haplotypeOffspring survivalReproductive performanceLarvae deformityPiscicultura3105.02 PisciculturaThe major histocompatibility complex (MHC) consists of genes involved in immune response and molecular discrimination between self and non-self. MHC genes are the most polymorphic in vertebrates. The origin and maintenance of polymorphism in MHC genes in populations is still unresolved. Mechanisms such as sexual selection and heterozygote advantage have been suggested as explanations for this high variability. In this study, a farmed population of rainbow trout (Oncorhynchus mykiss) characterized by the presence of specific MHC class IIB gene haplotypes at a frequency higher (30%) than that expected from random matings was investigated. Therefore, it was hypothesized that disassortative matings occur with an adaptive advantage for females, resulting in improved reproductive performance when mated with individuals with similar MHC haplotypes. Genetic analyses of the breeders were performed to define the MHC haplotypes and to perform specific matings. The effect of mating was evaluated by analyzing the survival rate of the offspring at various stages of incubation until swim-up. The reproductive performance of the offspring derived from specimens with similar haplotypes showed a better survival trend during the first life stages and reduced malformations. The results obtained are in contrast with the heterozygous advantage theory, therefore it was hypothesized, as for other salmonid species, the presence of a positive selection towards locally adapted MHC genes that promotes reproduction between genetically similar individuals.MDPIUniversidad Complutense de Madrid20242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/112817reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1128172026-06-02T12:44:21Z
dc.title.none.fl_str_mv Matings Between Individuals with Similar Major Histocompatibility Complex (MHC) Improve Offspring Survival in the Rainbow Trout (Oncorhynchus mykiss)
title Matings Between Individuals with Similar Major Histocompatibility Complex (MHC) Improve Offspring Survival in the Rainbow Trout (Oncorhynchus mykiss)
spellingShingle Matings Between Individuals with Similar Major Histocompatibility Complex (MHC) Improve Offspring Survival in the Rainbow Trout (Oncorhynchus mykiss)
Bergamino, Cinzia
639.3
Similar haplotype
Offspring survival
Reproductive performance
Larvae deformity
Piscicultura
3105.02 Piscicultura
title_short Matings Between Individuals with Similar Major Histocompatibility Complex (MHC) Improve Offspring Survival in the Rainbow Trout (Oncorhynchus mykiss)
title_full Matings Between Individuals with Similar Major Histocompatibility Complex (MHC) Improve Offspring Survival in the Rainbow Trout (Oncorhynchus mykiss)
title_fullStr Matings Between Individuals with Similar Major Histocompatibility Complex (MHC) Improve Offspring Survival in the Rainbow Trout (Oncorhynchus mykiss)
title_full_unstemmed Matings Between Individuals with Similar Major Histocompatibility Complex (MHC) Improve Offspring Survival in the Rainbow Trout (Oncorhynchus mykiss)
title_sort Matings Between Individuals with Similar Major Histocompatibility Complex (MHC) Improve Offspring Survival in the Rainbow Trout (Oncorhynchus mykiss)
dc.creator.none.fl_str_mv Bergamino, Cinzia
Tomasoni, Mattia
Colussi, Silvia
Montemurro, Vittoria
Altinok, Ilhan
Prearo, Marino
Kotzamanidis, Charalampos
Acutis, Pier Luigi
Vela Alonso, Ana Isabel
Sciuto, Simona
Esposito, Giuseppe
Volpatti, Donatella
Bozzetta, Elena
Parati, Katia
Aidos, Lucia
Fariano, Lucio
Sicuro, Benedetto
author Bergamino, Cinzia
author_facet Bergamino, Cinzia
Tomasoni, Mattia
Colussi, Silvia
Montemurro, Vittoria
Altinok, Ilhan
Prearo, Marino
Kotzamanidis, Charalampos
Acutis, Pier Luigi
Vela Alonso, Ana Isabel
Sciuto, Simona
Esposito, Giuseppe
Volpatti, Donatella
Bozzetta, Elena
Parati, Katia
Aidos, Lucia
Fariano, Lucio
Sicuro, Benedetto
author_role author
author2 Tomasoni, Mattia
Colussi, Silvia
Montemurro, Vittoria
Altinok, Ilhan
Prearo, Marino
Kotzamanidis, Charalampos
Acutis, Pier Luigi
Vela Alonso, Ana Isabel
Sciuto, Simona
Esposito, Giuseppe
Volpatti, Donatella
Bozzetta, Elena
Parati, Katia
Aidos, Lucia
Fariano, Lucio
Sicuro, Benedetto
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 639.3
Similar haplotype
Offspring survival
Reproductive performance
Larvae deformity
Piscicultura
3105.02 Piscicultura
topic 639.3
Similar haplotype
Offspring survival
Reproductive performance
Larvae deformity
Piscicultura
3105.02 Piscicultura
description The major histocompatibility complex (MHC) consists of genes involved in immune response and molecular discrimination between self and non-self. MHC genes are the most polymorphic in vertebrates. The origin and maintenance of polymorphism in MHC genes in populations is still unresolved. Mechanisms such as sexual selection and heterozygote advantage have been suggested as explanations for this high variability. In this study, a farmed population of rainbow trout (Oncorhynchus mykiss) characterized by the presence of specific MHC class IIB gene haplotypes at a frequency higher (30%) than that expected from random matings was investigated. Therefore, it was hypothesized that disassortative matings occur with an adaptive advantage for females, resulting in improved reproductive performance when mated with individuals with similar MHC haplotypes. Genetic analyses of the breeders were performed to define the MHC haplotypes and to perform specific matings. The effect of mating was evaluated by analyzing the survival rate of the offspring at various stages of incubation until swim-up. The reproductive performance of the offspring derived from specimens with similar haplotypes showed a better survival trend during the first life stages and reduced malformations. The results obtained are in contrast with the heterozygous advantage theory, therefore it was hypothesized, as for other salmonid species, the presence of a positive selection towards locally adapted MHC genes that promotes reproduction between genetically similar individuals.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/112817
url https://hdl.handle.net/20.500.14352/112817
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411525297438720
score 15,812429

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