Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery

Cationic niosomes have become important non-viral vehicles for transporting a good number of small drug molecules and macromolecules. Growing interest shown by these colloidal nanoparticles in therapy is determined by their structural similarities to liposomes. Cationic niosomes are usually obtained...

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Autores: Grijalvo, Santiago, Puras, Gustavo, Zárate, Jon, Sainz-Ramos, Myriam, Qtaish, Nuseibah A. L., López, Tania, Mashal, Mohamed, Attia, Noha, Díaz Viñolas, David, Pons Pons, Ramon, Fernández, Eduardo, Pedraz, José Luís, Eritja Casadellà, Ramón
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/174631
Acceso en línea:http://hdl.handle.net/10261/174631
Access Level:acceso abierto
Palabra clave:Antisense oligonucleotides
Cationic lipids
Aptamers
Cationic niosomes
Gene delivery
Small interference RNA
Plasmids
Therapy
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spelling Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene DeliveryGrijalvo, SantiagoPuras, GustavoZárate, JonSainz-Ramos, MyriamQtaish, Nuseibah A. L.López, TaniaMashal, MohamedAttia, NohaDíaz Viñolas, DavidPons Pons, RamonFernández, EduardoPedraz, José LuísEritja Casadellà, RamónAntisense oligonucleotidesCationic lipidsAptamersCationic niosomesGene deliverySmall interference RNAPlasmidsTherapyCationic niosomes have become important non-viral vehicles for transporting a good number of small drug molecules and macromolecules. Growing interest shown by these colloidal nanoparticles in therapy is determined by their structural similarities to liposomes. Cationic niosomes are usually obtained from the self-assembly of non-ionic surfactant molecules. This process can be governed not only by the nature of such surfactants but also by others factors like the presence of additives, formulation preparation and properties of the encapsulated hydrophobic or hydrophilic molecules. This review is aimed at providing recent information for using cationic niosomes for gene delivery purposes with particular emphasis on improving the transportation of antisense oligonucleotides (ASOs), small interference RNAs (siRNAs), aptamers and plasmids (pDNA).The authors also wish to thank the intellectual and technical assistance from the ICTS “NANBIOSIS,” more specifically by the Drug Formulation Unit (U10) of the CIBER in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) at the University of Basque Country (UPV/EHU). Technical and human support provided by SGIker (UPV/EHU) is gratefully acknowledged. CIBER-BBN is an initiative funded by the VI National R + D + I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. The authors also want to thank Suzanne Renée Córdova for revising this manuscript.This research was funded by the Spanish Ministerio de Ciencia e Innovación (MICINN), grant numbers CTQ2017-84415-R, MAT2015-69967-C3-1R, CTQ2017—88948-P, CIBER-BBN, grant numbers CB06_01_0019, CB06_01_1028 and CB01_01_1053, by the Basque Country Government, grant number CGIC10/172 and the Generalitat de Catalunya, grant number 2017/SGR/114, 2017/SGR/670We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI)Peer reviewedMolecular Diversity Preservation InternationalConsejo Superior de Investigaciones Científicas (España)Agencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Eusko JaurlaritzaGeneralitat de CatalunyaEritja Casadellà, Ramón [0000-0001-5383-9334]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/174631reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#CTQ2017-84415-R/AEI/10.13039/501100011033info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015-69967-C3-1-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTQ2017-84415-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-88948-Phttps://doi.org/10.3390/pharmaceutics11020050Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1746312026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery
title Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery
spellingShingle Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery
Grijalvo, Santiago
Antisense oligonucleotides
Cationic lipids
Aptamers
Cationic niosomes
Gene delivery
Small interference RNA
Plasmids
Therapy
title_short Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery
title_full Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery
title_fullStr Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery
title_full_unstemmed Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery
title_sort Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery
dc.creator.none.fl_str_mv Grijalvo, Santiago
Puras, Gustavo
Zárate, Jon
Sainz-Ramos, Myriam
Qtaish, Nuseibah A. L.
López, Tania
Mashal, Mohamed
Attia, Noha
Díaz Viñolas, David
Pons Pons, Ramon
Fernández, Eduardo
Pedraz, José Luís
Eritja Casadellà, Ramón
author Grijalvo, Santiago
author_facet Grijalvo, Santiago
Puras, Gustavo
Zárate, Jon
Sainz-Ramos, Myriam
Qtaish, Nuseibah A. L.
López, Tania
Mashal, Mohamed
Attia, Noha
Díaz Viñolas, David
Pons Pons, Ramon
Fernández, Eduardo
Pedraz, José Luís
Eritja Casadellà, Ramón
author_role author
author2 Puras, Gustavo
Zárate, Jon
Sainz-Ramos, Myriam
Qtaish, Nuseibah A. L.
López, Tania
Mashal, Mohamed
Attia, Noha
Díaz Viñolas, David
Pons Pons, Ramon
Fernández, Eduardo
Pedraz, José Luís
Eritja Casadellà, Ramón
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas (España)
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Eusko Jaurlaritza
Generalitat de Catalunya
Eritja Casadellà, Ramón [0000-0001-5383-9334]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Antisense oligonucleotides
Cationic lipids
Aptamers
Cationic niosomes
Gene delivery
Small interference RNA
Plasmids
Therapy
topic Antisense oligonucleotides
Cationic lipids
Aptamers
Cationic niosomes
Gene delivery
Small interference RNA
Plasmids
Therapy
description Cationic niosomes have become important non-viral vehicles for transporting a good number of small drug molecules and macromolecules. Growing interest shown by these colloidal nanoparticles in therapy is determined by their structural similarities to liposomes. Cationic niosomes are usually obtained from the self-assembly of non-ionic surfactant molecules. This process can be governed not only by the nature of such surfactants but also by others factors like the presence of additives, formulation preparation and properties of the encapsulated hydrophobic or hydrophilic molecules. This review is aimed at providing recent information for using cationic niosomes for gene delivery purposes with particular emphasis on improving the transportation of antisense oligonucleotides (ASOs), small interference RNAs (siRNAs), aptamers and plasmids (pDNA).
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/174631
url http://hdl.handle.net/10261/174631
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
CTQ2017-84415-R/AEI/10.13039/501100011033
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015-69967-C3-1-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTQ2017-84415-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-88948-P
https://doi.org/10.3390/pharmaceutics11020050
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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