Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients

The importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. However, due to delays in turnaround time, low-quality tissue samples, and/or lack of standardization of testing methods a significant proportion...

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Autores: García-Foncillas, Jesús, Alba, Emilio|||0000-0002-3364-2603, Aranda Aguilar, Enrique|||0000-0002-5471-2842, Díaz-Rubio, Eduardo, López López, R., Tabernero, Josep|||0000-0002-2495-8139, Vivancos, Ana|||0000-0003-2888-6512
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:200591
Acceso en línea:https://ddd.uab.cat/record/200591
https://dx.doi.org/urn:doi:10.1093/annonc/mdx501
Access Level:acceso abierto
Palabra clave:Colorectal cancer
Mutation testing
Liquid biopsy
EGFR
Tumor resistance
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spelling Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patientsan expert taskforce reviewGarcía-Foncillas, JesúsAlba, Emilio|||0000-0002-3364-2603Aranda Aguilar, Enrique|||0000-0002-5471-2842Díaz-Rubio, EduardoLópez López, R.Tabernero, Josep|||0000-0002-2495-8139Vivancos, Ana|||0000-0003-2888-6512Colorectal cancerMutation testingLiquid biopsyEGFRTumor resistanceThe importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. However, due to delays in turnaround time, low-quality tissue samples, and/or lack of standardization of testing methods a significant proportion of patients are being treated without the information that Kirsten rat sarcoma and neuroblastoma rat sarcoma (RAS) testing can provide. The detection of mutated circulating tumor DNA by BEAMing technology addresses this gap in care and allows these patients to receive international guideline-recommended expanded RAS testing with rapid turnaround times. Furthermore, the overall concordance between OncoBEAM RAS colorectal cancer testing and standard of care tissue testing is very high (93.3%). This article presents an overview of the clinical utility and potential applications of this minimally invasive method, such as early detection of emergent resistance to anti-epidermal growth factor receptor therapy. If appropriately implemented, BEAMing technology holds considerable promise to enhance the quality of patient care and improve clinical outcomes. 22017-01-0120172017-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/200591https://dx.doi.org/urn:doi:10.1093/annonc/mdx501reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2005912026-06-06T12:50:31Z
dc.title.none.fl_str_mv Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients
an expert taskforce review
title Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients
spellingShingle Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients
García-Foncillas, Jesús
Colorectal cancer
Mutation testing
Liquid biopsy
EGFR
Tumor resistance
title_short Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients
title_full Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients
title_fullStr Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients
title_full_unstemmed Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients
title_sort Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients
dc.creator.none.fl_str_mv García-Foncillas, Jesús
Alba, Emilio|||0000-0002-3364-2603
Aranda Aguilar, Enrique|||0000-0002-5471-2842
Díaz-Rubio, Eduardo
López López, R.
Tabernero, Josep|||0000-0002-2495-8139
Vivancos, Ana|||0000-0003-2888-6512
author García-Foncillas, Jesús
author_facet García-Foncillas, Jesús
Alba, Emilio|||0000-0002-3364-2603
Aranda Aguilar, Enrique|||0000-0002-5471-2842
Díaz-Rubio, Eduardo
López López, R.
Tabernero, Josep|||0000-0002-2495-8139
Vivancos, Ana|||0000-0003-2888-6512
author_role author
author2 Alba, Emilio|||0000-0002-3364-2603
Aranda Aguilar, Enrique|||0000-0002-5471-2842
Díaz-Rubio, Eduardo
López López, R.
Tabernero, Josep|||0000-0002-2495-8139
Vivancos, Ana|||0000-0003-2888-6512
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Colorectal cancer
Mutation testing
Liquid biopsy
EGFR
Tumor resistance
topic Colorectal cancer
Mutation testing
Liquid biopsy
EGFR
Tumor resistance
description The importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. However, due to delays in turnaround time, low-quality tissue samples, and/or lack of standardization of testing methods a significant proportion of patients are being treated without the information that Kirsten rat sarcoma and neuroblastoma rat sarcoma (RAS) testing can provide. The detection of mutated circulating tumor DNA by BEAMing technology addresses this gap in care and allows these patients to receive international guideline-recommended expanded RAS testing with rapid turnaround times. Furthermore, the overall concordance between OncoBEAM RAS colorectal cancer testing and standard of care tissue testing is very high (93.3%). This article presents an overview of the clinical utility and potential applications of this minimally invasive method, such as early detection of emergent resistance to anti-epidermal growth factor receptor therapy. If appropriately implemented, BEAMing technology holds considerable promise to enhance the quality of patient care and improve clinical outcomes.
publishDate 2017
dc.date.none.fl_str_mv 2
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/200591
https://dx.doi.org/urn:doi:10.1093/annonc/mdx501
url https://ddd.uab.cat/record/200591
https://dx.doi.org/urn:doi:10.1093/annonc/mdx501
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
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