Antidepressant Effects of High and Low Frequency Repetitive Transcranial Magnetic Stimulation to the Dorsolateral Prefrontal Cortex
Repetitive transcranial magnetic stimulation(rTMS) has antidepressant effects in patients withmajor depressive disorder. The mechanisms of ac-tion and optimal stimulation parameters remainunclear. To test the hypothesis that rTMS exertsantidepressant effects either by enhancing left dor-solateral pr...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2007 |
| País: | España |
| Institución: | Universidad Católica de Valencia San Vicente Mártir |
| Repositorio: | RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir |
| Idioma: | inglés |
| OAI Identifier: | oai:riucv.ucv.es:20.500.12466/3298 |
| Acceso en línea: | http://hdl.handle.net/20.500.12466/3298 |
| Access Level: | acceso abierto |
| Palabra clave: | Antidepressants Dorsolateral Prefrontal Cortex Repetitive transcranial magnetic stimulation (rTMS) 3205.07 Neurología |
| Sumario: | Repetitive transcranial magnetic stimulation(rTMS) has antidepressant effects in patients withmajor depressive disorder. The mechanisms of ac-tion and optimal stimulation parameters remainunclear. To test the hypothesis that rTMS exertsantidepressant effects either by enhancing left dor-solateral prefrontal cortex (DLPFC) excitability orby decreasing right DLPFC excitability, the au-thors studied 45 patients with unipolar recurrentmajor depressive disorder in a double-blind, ran-domized, parallel group, sham-controlled trial. Pa-tients were randomized to receive 1 Hz or 10 HzrTMS to the left DLPFC, 1 Hz to the rightDLPFC or sham TMS. Left 10 Hz and right 1 HzrTMS showed similar significant antidepressanteffects. Other parameters led to no significantantidepressant effect |
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