Antidepressant Effects of High and Low Frequency Repetitive Transcranial Magnetic Stimulation to the Dorsolateral Prefrontal Cortex

Repetitive transcranial magnetic stimulation(rTMS) has antidepressant effects in patients withmajor depressive disorder. The mechanisms of ac-tion and optimal stimulation parameters remainunclear. To test the hypothesis that rTMS exertsantidepressant effects either by enhancing left dor-solateral pr...

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Bibliographic Details
Authors: Stern, William M., Tormos Muñoz, José María, Press, Daniel Z., Pearlman, C., Pascual Leone, Álvaro
Format: article
Publication Date:2007
Country:España
Institution:Universidad Católica de Valencia San Vicente Mártir
Repository:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Language:English
OAI Identifier:oai:riucv.ucv.es:20.500.12466/3298
Online Access:http://hdl.handle.net/20.500.12466/3298
Access Level:Open access
Keyword:Antidepressants
Dorsolateral Prefrontal Cortex
Repetitive transcranial magnetic stimulation (rTMS)
3205.07 Neurología
Description
Summary:Repetitive transcranial magnetic stimulation(rTMS) has antidepressant effects in patients withmajor depressive disorder. The mechanisms of ac-tion and optimal stimulation parameters remainunclear. To test the hypothesis that rTMS exertsantidepressant effects either by enhancing left dor-solateral prefrontal cortex (DLPFC) excitability orby decreasing right DLPFC excitability, the au-thors studied 45 patients with unipolar recurrentmajor depressive disorder in a double-blind, ran-domized, parallel group, sham-controlled trial. Pa-tients were randomized to receive 1 Hz or 10 HzrTMS to the left DLPFC, 1 Hz to the rightDLPFC or sham TMS. Left 10 Hz and right 1 HzrTMS showed similar significant antidepressanteffects. Other parameters led to no significantantidepressant effect

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