Effect of oral anticoagulants on the outcome of faecal immunochemical test

Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. Methods: Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml-1) between November 2008 and June 20...

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Autores: Bujanda, Luis, Sarasqueta, Cristina, Lanas, Angel, Quintero, Enrique, Cubiella, Joaquín, Hernández, Vicent, Morillas, Juan D., Perez-Fernández, T., Salas, D., Andreu, Montserrat, Carballo, F., Bessa i Caserras, Xavier, Portillo, I., Jover, Rodrigo, Balaguer Prunés, Francesc, Cosme, Ángel, Castells Garangou, Antoni
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/122159
Acceso en línea:https://hdl.handle.net/2445/122159
Access Level:acceso abierto
Palabra clave:Càncer colorectal
Anticoagulants (Medicina)
Immunoquímica
Colonoscòpia
Estudi de casos
Colorectal cancer
Anticoagulants (Medicine)
Immunochemistry
Colonoscopy
Case studies
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spelling Effect of oral anticoagulants on the outcome of faecal immunochemical testBujanda, LuisSarasqueta, CristinaLanas, AngelQuintero, EnriqueCubiella, JoaquínHernández, VicentMorillas, Juan D.Perez-Fernández, T.Salas, D.Andreu, MontserratCarballo, F.Bessa i Caserras, XavierPortillo, I.Jover, RodrigoBalaguer Prunés, FrancescCosme, ÁngelCastells Garangou, AntoniCàncer colorectalAnticoagulants (Medicina)ImmunoquímicaColonoscòpiaEstudi de casosColorectal cancerAnticoagulants (Medicine)ImmunochemistryColonoscopyCase studiesBackground: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. Methods: Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml-1) between November 2008 and June 2011. Results: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend ¼ 0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3-1.8; P ¼ 0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4-10.8; P ¼ 0.4). Conclusions: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.Cancer Research UK2018201820142018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion4 p.application/pdfhttps://hdl.handle.net/2445/122159Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/bjc.2014.38British Journal of Cancer, 2014, vol. 110, num. 5, p. 1334-1337https://doi.org/10.1038/bjc.2014.38cc-by-nc-sa (c) Bujanda, Luis et al., 2014http://creativecommons.org/licenses/by-nc-sa/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1221592026-05-29T05:05:01Z
dc.title.none.fl_str_mv Effect of oral anticoagulants on the outcome of faecal immunochemical test
title Effect of oral anticoagulants on the outcome of faecal immunochemical test
spellingShingle Effect of oral anticoagulants on the outcome of faecal immunochemical test
Bujanda, Luis
Càncer colorectal
Anticoagulants (Medicina)
Immunoquímica
Colonoscòpia
Estudi de casos
Colorectal cancer
Anticoagulants (Medicine)
Immunochemistry
Colonoscopy
Case studies
title_short Effect of oral anticoagulants on the outcome of faecal immunochemical test
title_full Effect of oral anticoagulants on the outcome of faecal immunochemical test
title_fullStr Effect of oral anticoagulants on the outcome of faecal immunochemical test
title_full_unstemmed Effect of oral anticoagulants on the outcome of faecal immunochemical test
title_sort Effect of oral anticoagulants on the outcome of faecal immunochemical test
dc.creator.none.fl_str_mv Bujanda, Luis
Sarasqueta, Cristina
Lanas, Angel
Quintero, Enrique
Cubiella, Joaquín
Hernández, Vicent
Morillas, Juan D.
Perez-Fernández, T.
Salas, D.
Andreu, Montserrat
Carballo, F.
Bessa i Caserras, Xavier
Portillo, I.
Jover, Rodrigo
Balaguer Prunés, Francesc
Cosme, Ángel
Castells Garangou, Antoni
author Bujanda, Luis
author_facet Bujanda, Luis
Sarasqueta, Cristina
Lanas, Angel
Quintero, Enrique
Cubiella, Joaquín
Hernández, Vicent
Morillas, Juan D.
Perez-Fernández, T.
Salas, D.
Andreu, Montserrat
Carballo, F.
Bessa i Caserras, Xavier
Portillo, I.
Jover, Rodrigo
Balaguer Prunés, Francesc
Cosme, Ángel
Castells Garangou, Antoni
author_role author
author2 Sarasqueta, Cristina
Lanas, Angel
Quintero, Enrique
Cubiella, Joaquín
Hernández, Vicent
Morillas, Juan D.
Perez-Fernández, T.
Salas, D.
Andreu, Montserrat
Carballo, F.
Bessa i Caserras, Xavier
Portillo, I.
Jover, Rodrigo
Balaguer Prunés, Francesc
Cosme, Ángel
Castells Garangou, Antoni
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer colorectal
Anticoagulants (Medicina)
Immunoquímica
Colonoscòpia
Estudi de casos
Colorectal cancer
Anticoagulants (Medicine)
Immunochemistry
Colonoscopy
Case studies
topic Càncer colorectal
Anticoagulants (Medicina)
Immunoquímica
Colonoscòpia
Estudi de casos
Colorectal cancer
Anticoagulants (Medicine)
Immunochemistry
Colonoscopy
Case studies
description Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. Methods: Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml-1) between November 2008 and June 2011. Results: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend ¼ 0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3-1.8; P ¼ 0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4-10.8; P ¼ 0.4). Conclusions: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.
publishDate 2014
dc.date.none.fl_str_mv 2014
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/122159
url https://hdl.handle.net/2445/122159
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/bjc.2014.38
British Journal of Cancer, 2014, vol. 110, num. 5, p. 1334-1337
https://doi.org/10.1038/bjc.2014.38
dc.rights.none.fl_str_mv cc-by-nc-sa (c) Bujanda, Luis et al., 2014
http://creativecommons.org/licenses/by-nc-sa/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-sa (c) Bujanda, Luis et al., 2014
http://creativecommons.org/licenses/by-nc-sa/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 4 p.
application/pdf
dc.publisher.none.fl_str_mv Cancer Research UK
publisher.none.fl_str_mv Cancer Research UK
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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