Effect of oral anticoagulants on the outcome of faecal immunochemical test

Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. Methods: Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml-1) between November 2008 and June 20...

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Detalles Bibliográficos
Autores: Bujanda, Luis, Sarasqueta, Cristina, Lanas, Angel, Quintero, Enrique, Cubiella, Joaquín, Hernández, Vicent, Morillas, Juan D., Perez-Fernández, T., Salas, D., Andreu, Montserrat, Carballo, F., Bessa i Caserras, Xavier, Portillo, I., Jover, Rodrigo, Balaguer Prunés, Francesc, Cosme, Ángel, Castells Garangou, Antoni
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/122159
Acceso en línea:https://hdl.handle.net/2445/122159
Access Level:acceso abierto
Palabra clave:Càncer colorectal
Anticoagulants (Medicina)
Immunoquímica
Colonoscòpia
Estudi de casos
Colorectal cancer
Anticoagulants (Medicine)
Immunochemistry
Colonoscopy
Case studies
Descripción
Sumario:Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. Methods: Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml-1) between November 2008 and June 2011. Results: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend ¼ 0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3-1.8; P ¼ 0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4-10.8; P ¼ 0.4). Conclusions: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.

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