The estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation

The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serol...

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Autores: Ginex, Tiziana, Marco-Marín, Clara, Wieczor, Miłosz, Mata, Carlos P., Krieger, James, Ruiz-Rodriguez, Paula, López-Redondo, Maria Luisa, Francésc-Gómez, Clara, Melero, Roberta, Sánchez-Sorzano, Carlos Oscar, Martínez, Marta, Gougeard, Nadine, Forcada-Nadal, Alicia, Zamora-Caballero, Sara, Gozalbo-Rovira, Roberto, Sanz-Frasquet, Carla, Arranz, Rocío, Bravo, Jeronimo, Rubio, Vicente, Marina, Alberto, Geller, Ron, Comas, Iñaki, Gil, Carmen, Coscolla, Mireia, Orozco López, Modesto, Llácer, José Luis, Carazo, Jose-Maria
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/193026
Acesso em linha:https://hdl.handle.net/2445/193026
Access Level:acceso abierto
Palavra-chave:SARS-CoV-2
Infeccions
Mutació (Biologia)
Vacunes
Infections
Mutation (Biology)
Vaccines
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spelling The estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutationGinex, TizianaMarco-Marín, ClaraWieczor, MiłoszMata, Carlos P.Krieger, JamesRuiz-Rodriguez, PaulaLópez-Redondo, Maria LuisaFrancésc-Gómez, ClaraMelero, RobertaSánchez-Sorzano, Carlos OscarMartínez, MartaGougeard, NadineForcada-Nadal, AliciaZamora-Caballero, SaraGozalbo-Rovira, RobertoSanz-Frasquet, CarlaArranz, RocíoBravo, JeronimoRubio, VicenteMarina, AlbertoGeller, RonComas, IñakiGil, CarmenCoscolla, MireiaOrozco López, ModestoLlácer, José LuisCarazo, Jose-MariaSARS-CoV-2InfeccionsMutació (Biologia)VacunesSARS-CoV-2InfectionsMutation (Biology)VaccinesThe S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies character-izing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectivenessPublic Library of Science (PLoS)2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/193026Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.ppat.1010631PLoS Pathogens, 2022, vol. 18, num. 7https://doi.org/10.1371/journal.ppat.1010631cc-by (c) Ginex, Tiziana et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1930262026-05-27T06:46:51Z
dc.title.none.fl_str_mv The estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation
title The estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation
spellingShingle The estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation
Ginex, Tiziana
SARS-CoV-2
Infeccions
Mutació (Biologia)
Vacunes
SARS-CoV-2
Infections
Mutation (Biology)
Vaccines
title_short The estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation
title_full The estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation
title_fullStr The estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation
title_full_unstemmed The estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation
title_sort The estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation
dc.creator.none.fl_str_mv Ginex, Tiziana
Marco-Marín, Clara
Wieczor, Miłosz
Mata, Carlos P.
Krieger, James
Ruiz-Rodriguez, Paula
López-Redondo, Maria Luisa
Francésc-Gómez, Clara
Melero, Roberta
Sánchez-Sorzano, Carlos Oscar
Martínez, Marta
Gougeard, Nadine
Forcada-Nadal, Alicia
Zamora-Caballero, Sara
Gozalbo-Rovira, Roberto
Sanz-Frasquet, Carla
Arranz, Rocío
Bravo, Jeronimo
Rubio, Vicente
Marina, Alberto
Geller, Ron
Comas, Iñaki
Gil, Carmen
Coscolla, Mireia
Orozco López, Modesto
Llácer, José Luis
Carazo, Jose-Maria
author Ginex, Tiziana
author_facet Ginex, Tiziana
Marco-Marín, Clara
Wieczor, Miłosz
Mata, Carlos P.
Krieger, James
Ruiz-Rodriguez, Paula
López-Redondo, Maria Luisa
Francésc-Gómez, Clara
Melero, Roberta
Sánchez-Sorzano, Carlos Oscar
Martínez, Marta
Gougeard, Nadine
Forcada-Nadal, Alicia
Zamora-Caballero, Sara
Gozalbo-Rovira, Roberto
Sanz-Frasquet, Carla
Arranz, Rocío
Bravo, Jeronimo
Rubio, Vicente
Marina, Alberto
Geller, Ron
Comas, Iñaki
Gil, Carmen
Coscolla, Mireia
Orozco López, Modesto
Llácer, José Luis
Carazo, Jose-Maria
author_role author
author2 Marco-Marín, Clara
Wieczor, Miłosz
Mata, Carlos P.
Krieger, James
Ruiz-Rodriguez, Paula
López-Redondo, Maria Luisa
Francésc-Gómez, Clara
Melero, Roberta
Sánchez-Sorzano, Carlos Oscar
Martínez, Marta
Gougeard, Nadine
Forcada-Nadal, Alicia
Zamora-Caballero, Sara
Gozalbo-Rovira, Roberto
Sanz-Frasquet, Carla
Arranz, Rocío
Bravo, Jeronimo
Rubio, Vicente
Marina, Alberto
Geller, Ron
Comas, Iñaki
Gil, Carmen
Coscolla, Mireia
Orozco López, Modesto
Llácer, José Luis
Carazo, Jose-Maria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SARS-CoV-2
Infeccions
Mutació (Biologia)
Vacunes
SARS-CoV-2
Infections
Mutation (Biology)
Vaccines
topic SARS-CoV-2
Infeccions
Mutació (Biologia)
Vacunes
SARS-CoV-2
Infections
Mutation (Biology)
Vaccines
description The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies character-izing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectiveness
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/193026
url https://hdl.handle.net/2445/193026
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.ppat.1010631
PLoS Pathogens, 2022, vol. 18, num. 7
https://doi.org/10.1371/journal.ppat.1010631
dc.rights.none.fl_str_mv cc-by (c) Ginex, Tiziana et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Ginex, Tiziana et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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