The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serol...

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Detalles Bibliográficos
Autores: Ginex, Tiziana, Marco Marín, Clara, Wieczór, Miłosz, Mata, Carlos P., Krieger, James, Ruiz Rodriguez, Paula, López Redondo, Maria Luisa, Francés Gómez, Clara, Melero, Roberto, Sánchez Sorzano, Carlos Óscar, Martínez, Marta, Gougeard, Nadine, Forcada Nadal, Alicia, Zamora Caballero, Sara, Gozalbo Rovira, Roberto, Sanz Frasquet, Carla, Arranz, Rocío, Bravo, Jeronimo, Rubio, Vicente, Marina, Alberto, Geller, Ron, Comas, Iñaki, Gil, Carmen, Coscolla, Mireia, Orozco López, Modesto, Llácer, José Luis, Carazo, Jose Maria, The IBV Covid19 Pipeline
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/189320
Acceso en línea:https://hdl.handle.net/2445/189320
Access Level:acceso abierto
Palabra clave:SARS-CoV-2
Mutació (Biologia)
Mutation (Biology)
Descripción
Sumario:The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies characterizing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectiveness.

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