Brassinosteroid-regulated bHLH transcription factor CESTA induces the gibberellin 2-oxidase GA2ox7.

Brassinosteroids (BRs) are plant steroids that have growth-promoting capacities, which are partly enabled by an ability to induce biosynthesis of gibberellins (GAs), a second class of plant hormones. In addition, BRs can also activate GA catabolism; here we show that in Arabidopsis (Arabidopsis thal...

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Detalles Bibliográficos
Autores: Albertos, Pablo, Wlk, Tanja, Griffiths, Jayne, Pimenta Lange, Maria J, Unterholzner, Simon J, Rozhon, Wilfried, Lange, Theo, Jones, Alexander M, Poppenberger, Brigitte
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/169204
Acceso en línea:http://hdl.handle.net/10366/169204
Access Level:acceso abierto
Palabra clave:Arabidopsis
Basic Helix-Loop-Helix Transcription Factors
Brassinosteroids
Gibberellins
Plant growth and development
catabolism
Arabidopsis Proteins
Mixed Function Oxygenases
Gene Expression Regulation
Plant Growth Regulators
oxigenasas de función múltiple
regulación de la expresión génica
proteínas de arabidopsis
brasinoesteroides
factores de transcripción con hélice-asa-hélice básico
reguladores del crecimiento de las plantas
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spelling Brassinosteroid-regulated bHLH transcription factor CESTA induces the gibberellin 2-oxidase GA2ox7.Albertos, PabloWlk, TanjaGriffiths, JaynePimenta Lange, Maria JUnterholzner, Simon JRozhon, WilfriedLange, TheoJones, Alexander MPoppenberger, BrigitteArabidopsisBasic Helix-Loop-Helix Transcription FactorsBrassinosteroidsGibberellinsPlant growth and developmentcatabolismArabidopsisArabidopsis ProteinsMixed Function OxygenasesGene Expression RegulationBasic Helix-Loop-Helix Transcription FactorsBrassinosteroidsPlant Growth Regulatorsoxigenasas de función múltipleregulación de la expresión génicaproteínas de arabidopsisbrasinoesteroidesArabidopsisfactores de transcripción con hélice-asa-hélice básicoreguladores del crecimiento de las plantasBrassinosteroids (BRs) are plant steroids that have growth-promoting capacities, which are partly enabled by an ability to induce biosynthesis of gibberellins (GAs), a second class of plant hormones. In addition, BRs can also activate GA catabolism; here we show that in Arabidopsis (Arabidopsis thaliana) the basic helix-loop-helix transcription factor CESTA (CES) and its homologues BRASSINOSTEROID-ENHANCED EXPRESSION (BEE) 1 and 3 contribute to this activity. CES and the BEEs are BR-regulated at the transcriptional and posttranslational level and participate in different physiological processes, including vegetative and reproduction development, shade avoidance, and cold stress responses. We show that CES/BEEs can induce the expression of the class III GA 2-oxidase GA2ox7 and that this activity is increased by BRs. In BR signaling - and CES/BEE-deficient mutants, GA2ox7 expression decreased, yielding reduced levels of GA110, a product of GA2ox7 activity. In plants that over-express CES, GA2ox7 expression is hyper-responsive to BR, GA110 levels are elevated and amounts of bioactive GA are reduced. We provide evidence that CES directly binds to the GA2ox7 promoter and is activated by BRs, but can also act by BR-independent means. Based on these results, we propose a model for CES activity in GA catabolism where CES can be recruited for GA2ox7 induction not only by BR, but also by other factors.Oxford University Press202620262022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/169204reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésPO1640/4 Deutsche Forschungsgemeinschaft DFGPO1640/6 Deutsche Forschungsgemeinschaft DFGSFB924-TP12 Deutsche Forschungsgemeinschaft DFGAlexander von Humboldt Foundation Research Fellowships 2017-2019, ref. ESP/1188088European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no 759282)info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1692042026-06-07T06:28:51Z
dc.title.none.fl_str_mv Brassinosteroid-regulated bHLH transcription factor CESTA induces the gibberellin 2-oxidase GA2ox7.
title Brassinosteroid-regulated bHLH transcription factor CESTA induces the gibberellin 2-oxidase GA2ox7.
spellingShingle Brassinosteroid-regulated bHLH transcription factor CESTA induces the gibberellin 2-oxidase GA2ox7.
Albertos, Pablo
Arabidopsis
Basic Helix-Loop-Helix Transcription Factors
Brassinosteroids
Gibberellins
Plant growth and development
catabolism
Arabidopsis
Arabidopsis Proteins
Mixed Function Oxygenases
Gene Expression Regulation
Basic Helix-Loop-Helix Transcription Factors
Brassinosteroids
Plant Growth Regulators
oxigenasas de función múltiple
regulación de la expresión génica
proteínas de arabidopsis
brasinoesteroides
Arabidopsis
factores de transcripción con hélice-asa-hélice básico
reguladores del crecimiento de las plantas
title_short Brassinosteroid-regulated bHLH transcription factor CESTA induces the gibberellin 2-oxidase GA2ox7.
title_full Brassinosteroid-regulated bHLH transcription factor CESTA induces the gibberellin 2-oxidase GA2ox7.
title_fullStr Brassinosteroid-regulated bHLH transcription factor CESTA induces the gibberellin 2-oxidase GA2ox7.
title_full_unstemmed Brassinosteroid-regulated bHLH transcription factor CESTA induces the gibberellin 2-oxidase GA2ox7.
title_sort Brassinosteroid-regulated bHLH transcription factor CESTA induces the gibberellin 2-oxidase GA2ox7.
dc.creator.none.fl_str_mv Albertos, Pablo
Wlk, Tanja
Griffiths, Jayne
Pimenta Lange, Maria J
Unterholzner, Simon J
Rozhon, Wilfried
Lange, Theo
Jones, Alexander M
Poppenberger, Brigitte
author Albertos, Pablo
author_facet Albertos, Pablo
Wlk, Tanja
Griffiths, Jayne
Pimenta Lange, Maria J
Unterholzner, Simon J
Rozhon, Wilfried
Lange, Theo
Jones, Alexander M
Poppenberger, Brigitte
author_role author
author2 Wlk, Tanja
Griffiths, Jayne
Pimenta Lange, Maria J
Unterholzner, Simon J
Rozhon, Wilfried
Lange, Theo
Jones, Alexander M
Poppenberger, Brigitte
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Arabidopsis
Basic Helix-Loop-Helix Transcription Factors
Brassinosteroids
Gibberellins
Plant growth and development
catabolism
Arabidopsis
Arabidopsis Proteins
Mixed Function Oxygenases
Gene Expression Regulation
Basic Helix-Loop-Helix Transcription Factors
Brassinosteroids
Plant Growth Regulators
oxigenasas de función múltiple
regulación de la expresión génica
proteínas de arabidopsis
brasinoesteroides
Arabidopsis
factores de transcripción con hélice-asa-hélice básico
reguladores del crecimiento de las plantas
topic Arabidopsis
Basic Helix-Loop-Helix Transcription Factors
Brassinosteroids
Gibberellins
Plant growth and development
catabolism
Arabidopsis
Arabidopsis Proteins
Mixed Function Oxygenases
Gene Expression Regulation
Basic Helix-Loop-Helix Transcription Factors
Brassinosteroids
Plant Growth Regulators
oxigenasas de función múltiple
regulación de la expresión génica
proteínas de arabidopsis
brasinoesteroides
Arabidopsis
factores de transcripción con hélice-asa-hélice básico
reguladores del crecimiento de las plantas
description Brassinosteroids (BRs) are plant steroids that have growth-promoting capacities, which are partly enabled by an ability to induce biosynthesis of gibberellins (GAs), a second class of plant hormones. In addition, BRs can also activate GA catabolism; here we show that in Arabidopsis (Arabidopsis thaliana) the basic helix-loop-helix transcription factor CESTA (CES) and its homologues BRASSINOSTEROID-ENHANCED EXPRESSION (BEE) 1 and 3 contribute to this activity. CES and the BEEs are BR-regulated at the transcriptional and posttranslational level and participate in different physiological processes, including vegetative and reproduction development, shade avoidance, and cold stress responses. We show that CES/BEEs can induce the expression of the class III GA 2-oxidase GA2ox7 and that this activity is increased by BRs. In BR signaling - and CES/BEE-deficient mutants, GA2ox7 expression decreased, yielding reduced levels of GA110, a product of GA2ox7 activity. In plants that over-express CES, GA2ox7 expression is hyper-responsive to BR, GA110 levels are elevated and amounts of bioactive GA are reduced. We provide evidence that CES directly binds to the GA2ox7 promoter and is activated by BRs, but can also act by BR-independent means. Based on these results, we propose a model for CES activity in GA catabolism where CES can be recruited for GA2ox7 induction not only by BR, but also by other factors.
publishDate 2022
dc.date.none.fl_str_mv 2022
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/169204
url http://hdl.handle.net/10366/169204
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PO1640/4 Deutsche Forschungsgemeinschaft DFG
PO1640/6 Deutsche Forschungsgemeinschaft DFG
SFB924-TP12 Deutsche Forschungsgemeinschaft DFG
Alexander von Humboldt Foundation Research Fellowships 2017-2019, ref. ESP/1188088
European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no 759282)
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411407282307072
score 15,811543

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