Atypical, non-standard functions of the microtubule associated Tau protein

Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau's role in microtubule stability and regulation, as well as on the neuropathological consequences of Tau hyperphosphorylation and aggregation in Alzheimer's disease (AD)...

ver descrição completa

Detalhes bibliográficos
Autores: Sotiropoulos, Ioannis, Galassi, Marie-Christine, Silva, Joana M., Skoulakis, Efthimios, Wegmann, Susanne, Maina, Mahmoud B., Blum, David, Sayas, Carmen Laura, Mandelkow, Eva-Maria, Mandelkow, Eckhard, Spillantini, Maria G., Sousa, Nuno, Ávila, Jesús, Medina, Miguel, Mudher, Amrit, Buee, Luc
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/253672
Acesso em linha:http://hdl.handle.net/10261/253672
Access Level:acceso abierto
Palavra-chave:Tau, Alzheimer’s disease
Neuronal function
Pathology
Nucleus
Dendrites
Synapse
Subcellular localization
Tau isoform
id ES_79fcd7da8df2df85315c3c558217f2d1
oai_identifier_str oai:digital.csic.es:10261/253672
network_acronym_str ES
network_name_str España
repository_id_str
spelling Atypical, non-standard functions of the microtubule associated Tau proteinSotiropoulos, IoannisGalassi, Marie-ChristineSilva, Joana M.Skoulakis, EfthimiosWegmann, SusanneMaina, Mahmoud B.Blum, DavidSayas, Carmen LauraMandelkow, Eva-MariaMandelkow, EckhardSpillantini, Maria G.Sousa, NunoÁvila, JesúsMedina, MiguelMudher, AmritBuee, LucTau, Alzheimer’s diseaseNeuronal functionPathologyNucleusDendritesSynapseSubcellular localizationTau isoformSince the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau's role in microtubule stability and regulation, as well as on the neuropathological consequences of Tau hyperphosphorylation and aggregation in Alzheimer's disease (AD) brains. In recent years, however, research efforts identified new interaction partners and different sub-cellular localizations for Tau suggesting additional roles beyond its standard function as microtubule regulating protein. Moreover, despite the increasing research focus on AD over the last decades, Tau was only recently considered as a promising therapeutic target for the treatment and prevention of AD as well as for neurological pathologies beyond AD e.g. epilepsy, excitotoxicity, and environmental stress. This review will focus on atypical, non-standard roles of Tau on neuronal function and dysfunction in AD and other neurological pathologies providing novel insights about neuroplastic and neuropathological implications of Tau in both the central and the peripheral nervous system.Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120172021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/253672reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1186/s40478-017-0489-6Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2536722026-05-22T06:33:51Z
dc.title.none.fl_str_mv Atypical, non-standard functions of the microtubule associated Tau protein
title Atypical, non-standard functions of the microtubule associated Tau protein
spellingShingle Atypical, non-standard functions of the microtubule associated Tau protein
Sotiropoulos, Ioannis
Tau, Alzheimer’s disease
Neuronal function
Pathology
Nucleus
Dendrites
Synapse
Subcellular localization
Tau isoform
title_short Atypical, non-standard functions of the microtubule associated Tau protein
title_full Atypical, non-standard functions of the microtubule associated Tau protein
title_fullStr Atypical, non-standard functions of the microtubule associated Tau protein
title_full_unstemmed Atypical, non-standard functions of the microtubule associated Tau protein
title_sort Atypical, non-standard functions of the microtubule associated Tau protein
dc.creator.none.fl_str_mv Sotiropoulos, Ioannis
Galassi, Marie-Christine
Silva, Joana M.
Skoulakis, Efthimios
Wegmann, Susanne
Maina, Mahmoud B.
Blum, David
Sayas, Carmen Laura
Mandelkow, Eva-Maria
Mandelkow, Eckhard
Spillantini, Maria G.
Sousa, Nuno
Ávila, Jesús
Medina, Miguel
Mudher, Amrit
Buee, Luc
author Sotiropoulos, Ioannis
author_facet Sotiropoulos, Ioannis
Galassi, Marie-Christine
Silva, Joana M.
Skoulakis, Efthimios
Wegmann, Susanne
Maina, Mahmoud B.
Blum, David
Sayas, Carmen Laura
Mandelkow, Eva-Maria
Mandelkow, Eckhard
Spillantini, Maria G.
Sousa, Nuno
Ávila, Jesús
Medina, Miguel
Mudher, Amrit
Buee, Luc
author_role author
author2 Galassi, Marie-Christine
Silva, Joana M.
Skoulakis, Efthimios
Wegmann, Susanne
Maina, Mahmoud B.
Blum, David
Sayas, Carmen Laura
Mandelkow, Eva-Maria
Mandelkow, Eckhard
Spillantini, Maria G.
Sousa, Nuno
Ávila, Jesús
Medina, Miguel
Mudher, Amrit
Buee, Luc
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Tau, Alzheimer’s disease
Neuronal function
Pathology
Nucleus
Dendrites
Synapse
Subcellular localization
Tau isoform
topic Tau, Alzheimer’s disease
Neuronal function
Pathology
Nucleus
Dendrites
Synapse
Subcellular localization
Tau isoform
description Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau's role in microtubule stability and regulation, as well as on the neuropathological consequences of Tau hyperphosphorylation and aggregation in Alzheimer's disease (AD) brains. In recent years, however, research efforts identified new interaction partners and different sub-cellular localizations for Tau suggesting additional roles beyond its standard function as microtubule regulating protein. Moreover, despite the increasing research focus on AD over the last decades, Tau was only recently considered as a promising therapeutic target for the treatment and prevention of AD as well as for neurological pathologies beyond AD e.g. epilepsy, excitotoxicity, and environmental stress. This review will focus on atypical, non-standard roles of Tau on neuronal function and dysfunction in AD and other neurological pathologies providing novel insights about neuroplastic and neuropathological implications of Tau in both the central and the peripheral nervous system.
publishDate 2017
dc.date.none.fl_str_mv 2017
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/253672
url http://hdl.handle.net/10261/253672
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1186/s40478-017-0489-6
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411403764334592
score 15.812429

Registos relacionados