Tau and neuron aging
Tau protein could appear like a family of multiple isoforms rising by alternative splicing of its nuclear RNA or by different posttranslational modifications. The levels (or proportion) of these different tau isoforms could change in different neurons during development, aging or disease (tauopathie...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/252280 |
| Acceso en línea: | http://hdl.handle.net/10261/252280 |
| Access Level: | acceso abierto |
| Palabra clave: | Tau isoforms Posttranslational modifications Alzheimer disease |
| Sumario: | Tau protein could appear like a family of multiple isoforms rising by alternative splicing of its nuclear RNA or by different posttranslational modifications. The levels (or proportion) of these different tau isoforms could change in different neurons during development, aging or disease (tauopathies) in mammals. It is discussed that in some disorders there is a gain of toxic function of modified tau, due to the phosphorylation or aggregation of tau protein. These phenotypic changes are mainly found in aging organisms. On the other hand, loss of tau function could facilitate the appearance of some defects (related to iron toxicity) in aging animals lacking tau. |
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