Resistance artery vasodilator pathways involved in the antihypertensive effects of coca shell extract in rats exposed to fetal undernutrition
The present study evaluated the antihypertensive capacity of an extract derived from cocoashell (CSE), a by-product from the cocoa industry in a rat model of fetal programming of hypertension. Maleoffspring from dams with 50% nutrient restriction from mid-gestation (MUN rat) develop hypertension, wh...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/715673 |
| Acceso en línea: | http://hdl.handle.net/10486/715673 https://dx.doi.org/10.1113/jp287097 |
| Access Level: | acceso abierto |
| Palabra clave: | Cocoa Shell DOHaD Hypertension Nutraceuticals Resistance Arteries Superoxide Anion Vasodilatation Medicina |
| Sumario: | The present study evaluated the antihypertensive capacity of an extract derived from cocoashell (CSE), a by-product from the cocoa industry in a rat model of fetal programming of hypertension. Maleoffspring from dams with 50% nutrient restriction from mid-gestation (MUN rat) develop hypertension, whereasfemales remain normotensive. Resistance arteries from males, but not females, exhibit impaired endothelium-dependentand independent vasodilatation and elevated superoxide anion production. Supplementation of MUN rats with CSEimproved resistance artery function, as well as reduced superoxide anion generation and blood pressure. CSE canbe a food ingredient with antihypertensive actions, in addition to contributing to the circular economy |
|---|