Phenol-enriched olive oils modify paraoxonase-related variables: A randomized, crossover, controlled trial

Scope:Low paraoxonase (PON)1 activities, and high PON1 and low PON3 protein levels arecharacteristic of cardiovascular disease. Our aim was to assess short- and long-term effects ofvirgin olive oils (VOO), enriched with their own phenolic compounds (PC; FVOO) or with themplus complementary PC from t...

Descripción completa

Detalles Bibliográficos
Autores: Fernández Castillejo, Sara, García Heredia, Ana Isabel, Solà, Rosa, Camps, Jordi, López de las Hazas Mingo, María del Carmen, Farràs, Marta, Pedret, Anna, Catalán Santos, Úrsula, Rubió Piqué, Laura, Motilva Casado, Mª José, Castañer, Olga, Covas Planells, María Isabel, Valls, Rosa M.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/71570
Acceso en línea:https://doi.org/10.1002/mnfr.201600932
http://hdl.handle.net/10459.1/71570
Access Level:acceso abierto
Palabra clave:Flavonoids
Olive oil
Phenolic compounds
PON
Secoiridoids
id ES_79543ed65e6b1bd2aff013afe15b2bcf
oai_identifier_str oai:recercat.cat:10459.1/71570
network_acronym_str ES
network_name_str España
repository_id_str
spelling Phenol-enriched olive oils modify paraoxonase-related variables: A randomized, crossover, controlled trialFernández Castillejo, SaraGarcía Heredia, Ana IsabelSolà, RosaCamps, JordiLópez de las Hazas Mingo, María del CarmenFarràs, MartaPedret, AnnaCatalán Santos, ÚrsulaRubió Piqué, LauraMotilva Casado, Mª JoséCastañer, OlgaCovas Planells, María IsabelValls, Rosa M.FlavonoidsOlive oilPhenolic compoundsPONSecoiridoidsScope:Low paraoxonase (PON)1 activities, and high PON1 and low PON3 protein levels arecharacteristic of cardiovascular disease. Our aim was to assess short- and long-term effects ofvirgin olive oils (VOO), enriched with their own phenolic compounds (PC; FVOO) or with themplus complementary PC from thyme (FVOOT), on PON-related variables and the mechanismsinvolved.Methods and results:Two randomized, controlled, double-blind, and crossover interventionswere conducted. In an acute intake study, participants ingested three FVOOs differing in PCcontent. In a sustained intake study, participants ingested a control VOO and two differentFVOOs with the same PC content but differing in PC source. Acute and sustained intake ofVOO and FVOO decreased PON1 protein and increased PON1-associated specific activities,while FVOOT yielded opposite results. PON3 protein levels increased only after sustainedconsumption of VOO. Mechanistic studies performed in rat livers showed that intake of isolatedPC from VOO and from thyme modulate mitogen-activated protein kinases and peroxisomeproliferator-activated receptors regulating PON synthesis, while a combination of these PCscancels such regulation.Conclusion:This study reveals that the intake of phenol-enriched FVOOs modulates oxidativebalance by modifying PON-related variables according to PC content and source, and thismodulation can be perceived as beneficial.This study was supported by the Spanish Ministry of Econ-omy (MINECO) financing the projects AGL2009-13517-457-C03-01, C03-02 and C03-3, AGL2012-40144-C01-03, C02-03 and C03-03, and the FPI-fellowship (BES-2010-040766), byC©2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimwww.mnf-journal.com 1600932 (11 of 13)S. Fern ́andez-Castillejo et al.Mol. Nutr. Food Res. 61,10, 2017, 1600932a contract from the Catalan Government, and by grants fromISCIII FEDER (CB06/03/0028), AGAUR(2014SGR240) andAGAUR (2014SGR783). AP is a Torres Quevedo contract (PTQ-15-08068; Subprograma Estatal de Incorporaci ́on, Plan Estatalde Investigaci ́on Cient ́ıfica y T ́ecnica y de Innovaci ́on). UC is aPERIS contract (SLT002/16/00239; Pla estrat`egic de recerca iinnovaci ́o en salut). LR is Sara Borell contract (CD14/00275)co-financed by and IISPV. OC was supported by a research con-tract of Carlos III (SCIII JR14/00008). Thanks to the Universityof Lleida for the M-CLH PhD. grant.Wiley202120212017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttps://doi.org/10.1002/mnfr.201600932http://hdl.handle.net/10459.1/71570http://hdl.handle.net/10459.1/71570reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/grantAgreement/MICINN//AGL2009-13517-C03-01info:eu-repo/grantAgreement/MICINN//AGL2009-13517-C03-02info:eu-repo/grantAgreement/MICINN//AGL2009-13517-C03-03info:eu-repo/grantAgreement/MINECO//AGL2012-40144-C03-01info:eu-repo/grantAgreement/MINECO//AGL2012-40144-C03-02info:eu-repo/grantAgreement/MINECO//AGL2012-40144-C03-03Versió postprint del document publicat a: https://doi.org/10.1002/mnfr.201600932Molecular Nutrition & Food Research, vol. 61, núm. 10, art. 1600932(c) WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim, 2017info:eu-repo/semantics/openAccessoai:recercat.cat:10459.1/715702026-05-29T05:05:01Z
dc.title.none.fl_str_mv Phenol-enriched olive oils modify paraoxonase-related variables: A randomized, crossover, controlled trial
title Phenol-enriched olive oils modify paraoxonase-related variables: A randomized, crossover, controlled trial
spellingShingle Phenol-enriched olive oils modify paraoxonase-related variables: A randomized, crossover, controlled trial
Fernández Castillejo, Sara
Flavonoids
Olive oil
Phenolic compounds
PON
Secoiridoids
title_short Phenol-enriched olive oils modify paraoxonase-related variables: A randomized, crossover, controlled trial
title_full Phenol-enriched olive oils modify paraoxonase-related variables: A randomized, crossover, controlled trial
title_fullStr Phenol-enriched olive oils modify paraoxonase-related variables: A randomized, crossover, controlled trial
title_full_unstemmed Phenol-enriched olive oils modify paraoxonase-related variables: A randomized, crossover, controlled trial
title_sort Phenol-enriched olive oils modify paraoxonase-related variables: A randomized, crossover, controlled trial
dc.creator.none.fl_str_mv Fernández Castillejo, Sara
García Heredia, Ana Isabel
Solà, Rosa
Camps, Jordi
López de las Hazas Mingo, María del Carmen
Farràs, Marta
Pedret, Anna
Catalán Santos, Úrsula
Rubió Piqué, Laura
Motilva Casado, Mª José
Castañer, Olga
Covas Planells, María Isabel
Valls, Rosa M.
author Fernández Castillejo, Sara
author_facet Fernández Castillejo, Sara
García Heredia, Ana Isabel
Solà, Rosa
Camps, Jordi
López de las Hazas Mingo, María del Carmen
Farràs, Marta
Pedret, Anna
Catalán Santos, Úrsula
Rubió Piqué, Laura
Motilva Casado, Mª José
Castañer, Olga
Covas Planells, María Isabel
Valls, Rosa M.
author_role author
author2 García Heredia, Ana Isabel
Solà, Rosa
Camps, Jordi
López de las Hazas Mingo, María del Carmen
Farràs, Marta
Pedret, Anna
Catalán Santos, Úrsula
Rubió Piqué, Laura
Motilva Casado, Mª José
Castañer, Olga
Covas Planells, María Isabel
Valls, Rosa M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Flavonoids
Olive oil
Phenolic compounds
PON
Secoiridoids
topic Flavonoids
Olive oil
Phenolic compounds
PON
Secoiridoids
description Scope:Low paraoxonase (PON)1 activities, and high PON1 and low PON3 protein levels arecharacteristic of cardiovascular disease. Our aim was to assess short- and long-term effects ofvirgin olive oils (VOO), enriched with their own phenolic compounds (PC; FVOO) or with themplus complementary PC from thyme (FVOOT), on PON-related variables and the mechanismsinvolved.Methods and results:Two randomized, controlled, double-blind, and crossover interventionswere conducted. In an acute intake study, participants ingested three FVOOs differing in PCcontent. In a sustained intake study, participants ingested a control VOO and two differentFVOOs with the same PC content but differing in PC source. Acute and sustained intake ofVOO and FVOO decreased PON1 protein and increased PON1-associated specific activities,while FVOOT yielded opposite results. PON3 protein levels increased only after sustainedconsumption of VOO. Mechanistic studies performed in rat livers showed that intake of isolatedPC from VOO and from thyme modulate mitogen-activated protein kinases and peroxisomeproliferator-activated receptors regulating PON synthesis, while a combination of these PCscancels such regulation.Conclusion:This study reveals that the intake of phenol-enriched FVOOs modulates oxidativebalance by modifying PON-related variables according to PC content and source, and thismodulation can be perceived as beneficial.
publishDate 2017
dc.date.none.fl_str_mv 2017
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1002/mnfr.201600932
http://hdl.handle.net/10459.1/71570
http://hdl.handle.net/10459.1/71570
url https://doi.org/10.1002/mnfr.201600932
http://hdl.handle.net/10459.1/71570
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN//AGL2009-13517-C03-01
info:eu-repo/grantAgreement/MICINN//AGL2009-13517-C03-02
info:eu-repo/grantAgreement/MICINN//AGL2009-13517-C03-03
info:eu-repo/grantAgreement/MINECO//AGL2012-40144-C03-01
info:eu-repo/grantAgreement/MINECO//AGL2012-40144-C03-02
info:eu-repo/grantAgreement/MINECO//AGL2012-40144-C03-03
Versió postprint del document publicat a: https://doi.org/10.1002/mnfr.201600932
Molecular Nutrition & Food Research, vol. 61, núm. 10, art. 1600932
dc.rights.none.fl_str_mv (c) WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim, 2017
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim, 2017
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411340417761280
score 15.812429

Similares en LA Referencia