Recent advances on asymmetric nitroso aldol reaction

The reaction of aromatic nitroso derivatives with enolizable carbonyl compounds (nitroso aldol reaction) to give either α-hydroxyamino or α-aminoxy carbonyl compounds is an important synthetic method. This review illustrates the recent advances in rendering the process regio- and enantioselective as...

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Detalles Bibliográficos
Autores: Merino, Pedro, Tejero, Tomás, Delso, J. Ignacio, Matute, Rosa
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/155774
Acceso en línea:http://hdl.handle.net/10261/155774
Access Level:acceso abierto
Palabra clave:Aminoxylation
Asymmetric nitroso aldol
α-amino carbonyls
Hydroxyamination
Organocatalysts
α-hydroxy carbonyls
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spelling Recent advances on asymmetric nitroso aldol reactionMerino, PedroTejero, TomásDelso, J. IgnacioMatute, RosaAminoxylationAsymmetric nitroso aldolα-amino carbonylsHydroxyaminationOrganocatalystsα-hydroxy carbonylsThe reaction of aromatic nitroso derivatives with enolizable carbonyl compounds (nitroso aldol reaction) to give either α-hydroxyamino or α-aminoxy carbonyl compounds is an important synthetic method. This review illustrates the recent advances in rendering the process regio- and enantioselective as well as catalytic. By employing metal and organic catalysts a range of α-amino (α-oxyamination) and α-hydroxy (α-aminoxylation) carbonyl derivatives can be generated with total regioselectivity and high levels of enantiomeric excess.We thank for their support of our programs: MINECO (Madrid, Spain) and FEDER Program (Project CTQ2013-44367-C2-1-P) and the Government of Aragon, Spain (Bioorganic Chemistry Group E-10).Peer ReviewedThiemeMinisterio de Economía y Competitividad (España)Gobierno de AragónEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2017201720162017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/155774reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2013-44367-C2-1-Phttps://doi.org/10.1055/s-0035-1561505Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1557742026-05-22T06:33:51Z
dc.title.none.fl_str_mv Recent advances on asymmetric nitroso aldol reaction
title Recent advances on asymmetric nitroso aldol reaction
spellingShingle Recent advances on asymmetric nitroso aldol reaction
Merino, Pedro
Aminoxylation
Asymmetric nitroso aldol
α-amino carbonyls
Hydroxyamination
Organocatalysts
α-hydroxy carbonyls
title_short Recent advances on asymmetric nitroso aldol reaction
title_full Recent advances on asymmetric nitroso aldol reaction
title_fullStr Recent advances on asymmetric nitroso aldol reaction
title_full_unstemmed Recent advances on asymmetric nitroso aldol reaction
title_sort Recent advances on asymmetric nitroso aldol reaction
dc.creator.none.fl_str_mv Merino, Pedro
Tejero, Tomás
Delso, J. Ignacio
Matute, Rosa
author Merino, Pedro
author_facet Merino, Pedro
Tejero, Tomás
Delso, J. Ignacio
Matute, Rosa
author_role author
author2 Tejero, Tomás
Delso, J. Ignacio
Matute, Rosa
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Gobierno de Aragón
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Aminoxylation
Asymmetric nitroso aldol
α-amino carbonyls
Hydroxyamination
Organocatalysts
α-hydroxy carbonyls
topic Aminoxylation
Asymmetric nitroso aldol
α-amino carbonyls
Hydroxyamination
Organocatalysts
α-hydroxy carbonyls
description The reaction of aromatic nitroso derivatives with enolizable carbonyl compounds (nitroso aldol reaction) to give either α-hydroxyamino or α-aminoxy carbonyl compounds is an important synthetic method. This review illustrates the recent advances in rendering the process regio- and enantioselective as well as catalytic. By employing metal and organic catalysts a range of α-amino (α-oxyamination) and α-hydroxy (α-aminoxylation) carbonyl derivatives can be generated with total regioselectivity and high levels of enantiomeric excess.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/155774
url http://hdl.handle.net/10261/155774
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2013-44367-C2-1-P
https://doi.org/10.1055/s-0035-1561505
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Thieme
publisher.none.fl_str_mv Thieme
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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