Adopting a high-polyphenolic diet is associated with an improved glucose profile: Prospective analysis within the PREDIMED-Plus trial

Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose...

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Autores: Tresserra-Rimbau, Anna, Fitó Colomer, Montserrat, Castañer, Olga, López Grau, Mercè, Vila Vergaz, Manel, Salas Salvadó, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/53819
Acceso en línea:http://hdl.handle.net/10230/53819
http://dx.doi.org/10.3390/antiox11020316
Access Level:acceso abierto
Palabra clave:HbA1c
Mediterranean diet
Antioxidants
Flavonoids
Glucose
Glycosylated hemoglobin
Metabolic syndrome
Obesity
Phenolic acids
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv Adopting a high-polyphenolic diet is associated with an improved glucose profile: Prospective analysis within the PREDIMED-Plus trial
title Adopting a high-polyphenolic diet is associated with an improved glucose profile: Prospective analysis within the PREDIMED-Plus trial
spellingShingle Adopting a high-polyphenolic diet is associated with an improved glucose profile: Prospective analysis within the PREDIMED-Plus trial
Tresserra-Rimbau, Anna
HbA1c
Mediterranean diet
Antioxidants
Flavonoids
Glucose
Glycosylated hemoglobin
Metabolic syndrome
Obesity
Phenolic acids
title_short Adopting a high-polyphenolic diet is associated with an improved glucose profile: Prospective analysis within the PREDIMED-Plus trial
title_full Adopting a high-polyphenolic diet is associated with an improved glucose profile: Prospective analysis within the PREDIMED-Plus trial
title_fullStr Adopting a high-polyphenolic diet is associated with an improved glucose profile: Prospective analysis within the PREDIMED-Plus trial
title_full_unstemmed Adopting a high-polyphenolic diet is associated with an improved glucose profile: Prospective analysis within the PREDIMED-Plus trial
title_sort Adopting a high-polyphenolic diet is associated with an improved glucose profile: Prospective analysis within the PREDIMED-Plus trial
dc.creator.none.fl_str_mv Tresserra-Rimbau, Anna
Fitó Colomer, Montserrat
Castañer, Olga
López Grau, Mercè
Vila Vergaz, Manel
Salas Salvadó, Jordi
author Tresserra-Rimbau, Anna
author_facet Tresserra-Rimbau, Anna
Fitó Colomer, Montserrat
Castañer, Olga
López Grau, Mercè
Vila Vergaz, Manel
Salas Salvadó, Jordi
author_role author
author2 Fitó Colomer, Montserrat
Castañer, Olga
López Grau, Mercè
Vila Vergaz, Manel
Salas Salvadó, Jordi
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv HbA1c
Mediterranean diet
Antioxidants
Flavonoids
Glucose
Glycosylated hemoglobin
Metabolic syndrome
Obesity
Phenolic acids
topic HbA1c
Mediterranean diet
Antioxidants
Flavonoids
Glucose
Glycosylated hemoglobin
Metabolic syndrome
Obesity
Phenolic acids
description Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/53819
http://dx.doi.org/10.3390/antiox11020316
url http://hdl.handle.net/10230/53819
http://dx.doi.org/10.3390/antiox11020316
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Antioxidants (Basel). 2022 Feb 4;11(2):316
info:eu-repo/grantAgreement/EC/FP7/340918
info:eu-repo/grantAgreement/ES/1PE/AGL2016-75329-R
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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spelling Adopting a high-polyphenolic diet is associated with an improved glucose profile: Prospective analysis within the PREDIMED-Plus trialTresserra-Rimbau, AnnaFitó Colomer, MontserratCastañer, OlgaLópez Grau, MercèVila Vergaz, ManelSalas Salvadó, JordiHbA1cMediterranean dietAntioxidantsFlavonoidsGlucoseGlycosylated hemoglobinMetabolic syndromeObesityPhenolic acidsPrevious studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D.The PREDIMED-Plus trial was supported by the Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (six coordinated Fondo de Investigaciones Sanitarias projects leaded by J.S.-S. and J.V. (Josep Vidal), including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158)), the Especial Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., European Research Council (Advanced Research Grant 2014–2019, 340918) to M.Á.M.-G., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, a CICYT grant provided by the Ministerio de Ciencia, Innovación y Universidades (AGL2016-75329-R), and funds from the European Regional Development Fund (CB06/03). Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil for the PTREDIMED-Plus study, and the Almond Board of California (Modesto, CA, USA), American Pistachio Growers (Fresno, CA, USA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA, USA) donated nuts for the PREDIMED-Plus pilot study. J.K. supported with Juan de la Cierva-Incorporación research grant (IJC2019-042420-I) of the Spanish Ministry of Economy, Industry and Competitiveness and European Social Funds. This call was co-financed at 50% with charge to the Operational Program FSE 2014-2020 of the Balearic Islands. J.S.-S, senior author of this article, was partially supported by ICREA under the ICREA Academia programme.MDPI202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/53819http://dx.doi.org/10.3390/antiox11020316reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAntioxidants (Basel). 2022 Feb 4;11(2):316info:eu-repo/grantAgreement/EC/FP7/340918info:eu-repo/grantAgreement/ES/1PE/AGL2016-75329-R© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/538192026-05-29T05:05:01Z
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