Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus

Type-2 diabetes mellitus (T2DM) is a major systemic disease which involves impaired pancreatic function and currently affects half a billion people worldwide. Diet is considered the cornerstone to reduce incidence and prevalence of this disease. Algae contains fiber, polyphenols, ω-3 PUFAs, and bioa...

Descripción completa

Detalles Bibliográficos
Autores: Bocanegra De Juana, Aranzazu, Macho González, Adrián, Garcimartín Álvarez, Alba, Benedí González, Juana María, Sánchez Muniz, Francisco José
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/7431
Acceso en línea:https://hdl.handle.net/20.500.14352/7431
Access Level:acceso abierto
Palabra clave:615.322
616.379-008.64
Algae
Diabetes
Functional food
Functional meat
Microbiota
Metabolism
Gastroenterología y hepatología
Farmacología (Farmacia)
3205.03 Gastroenterología
3209 Farmacología
id ES_770107d1d8a883ca0e17c3bee1bf7452
oai_identifier_str oai:docta.ucm.es:20.500.14352/7431
network_acronym_str ES
network_name_str España
repository_id_str
spelling Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes MellitusBocanegra De Juana, AranzazuMacho González, AdriánGarcimartín Álvarez, AlbaBenedí González, Juana MaríaSánchez Muniz, Francisco José615.322616.379-008.64AlgaeDiabetesFunctional foodFunctional meatMicrobiotaMetabolismGastroenterología y hepatologíaFarmacología (Farmacia)3205.03 Gastroenterología3209 FarmacologíaType-2 diabetes mellitus (T2DM) is a major systemic disease which involves impaired pancreatic function and currently affects half a billion people worldwide. Diet is considered the cornerstone to reduce incidence and prevalence of this disease. Algae contains fiber, polyphenols, ω-3 PUFAs, and bioactive molecules with potential antidiabetic activity. This review delves into the applications of algae and their components in T2DM, as well as to ascertain the mechanism involved (e.g., glucose absorption, lipids metabolism, antioxidant properties, etc.). PubMed, and Google Scholar databases were used. Papers in which whole alga, algal extracts, or their isolated compounds were studied in in vitro conditions, T2DM experimental models, and humans were selected and discussed. This review also focuses on meat matrices or protein concentrate-based products in which different types of alga were included, aimed to modulate carbohydrate digestion and absorption, blood glucose, gastrointestinal neurohormones secretion, glycosylation products, and insulin resistance. As microbiota dysbiosis in T2DM and metabolic alterations in different organs are related, the review also delves on the effects of several bioactive algal compounds on the colon/microbiota-liver-pancreas-brain axis. As the responses to therapeutic diets vary dramatically among individuals due to genetic components, it seems a priority to identify major gene polymorphisms affecting potential positive effects of algal compounds on T2DM treatment.MDPIUniversidad Complutense de Madrid20212021-04-0720212021-04-07journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/7431reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/74312026-06-02T12:44:21Z
dc.title.none.fl_str_mv Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus
title Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus
spellingShingle Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus
Bocanegra De Juana, Aranzazu
615.322
616.379-008.64
Algae
Diabetes
Functional food
Functional meat
Microbiota
Metabolism
Gastroenterología y hepatología
Farmacología (Farmacia)
3205.03 Gastroenterología
3209 Farmacología
title_short Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus
title_full Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus
title_fullStr Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus
title_full_unstemmed Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus
title_sort Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus
dc.creator.none.fl_str_mv Bocanegra De Juana, Aranzazu
Macho González, Adrián
Garcimartín Álvarez, Alba
Benedí González, Juana María
Sánchez Muniz, Francisco José
author Bocanegra De Juana, Aranzazu
author_facet Bocanegra De Juana, Aranzazu
Macho González, Adrián
Garcimartín Álvarez, Alba
Benedí González, Juana María
Sánchez Muniz, Francisco José
author_role author
author2 Macho González, Adrián
Garcimartín Álvarez, Alba
Benedí González, Juana María
Sánchez Muniz, Francisco José
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615.322
616.379-008.64
Algae
Diabetes
Functional food
Functional meat
Microbiota
Metabolism
Gastroenterología y hepatología
Farmacología (Farmacia)
3205.03 Gastroenterología
3209 Farmacología
topic 615.322
616.379-008.64
Algae
Diabetes
Functional food
Functional meat
Microbiota
Metabolism
Gastroenterología y hepatología
Farmacología (Farmacia)
3205.03 Gastroenterología
3209 Farmacología
description Type-2 diabetes mellitus (T2DM) is a major systemic disease which involves impaired pancreatic function and currently affects half a billion people worldwide. Diet is considered the cornerstone to reduce incidence and prevalence of this disease. Algae contains fiber, polyphenols, ω-3 PUFAs, and bioactive molecules with potential antidiabetic activity. This review delves into the applications of algae and their components in T2DM, as well as to ascertain the mechanism involved (e.g., glucose absorption, lipids metabolism, antioxidant properties, etc.). PubMed, and Google Scholar databases were used. Papers in which whole alga, algal extracts, or their isolated compounds were studied in in vitro conditions, T2DM experimental models, and humans were selected and discussed. This review also focuses on meat matrices or protein concentrate-based products in which different types of alga were included, aimed to modulate carbohydrate digestion and absorption, blood glucose, gastrointestinal neurohormones secretion, glycosylation products, and insulin resistance. As microbiota dysbiosis in T2DM and metabolic alterations in different organs are related, the review also delves on the effects of several bioactive algal compounds on the colon/microbiota-liver-pancreas-brain axis. As the responses to therapeutic diets vary dramatically among individuals due to genetic components, it seems a priority to identify major gene polymorphisms affecting potential positive effects of algal compounds on T2DM treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-04-07
2021
2021-04-07
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/7431
url https://hdl.handle.net/20.500.14352/7431
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411091504693248
score 15,301603

Similares en LA Referencia