Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents

Burguete, A. (Asunción)|||/items/841509d2-131f-45ab-97cb-0e072035c61e; Pontiki, E. (Eleni)|||/items/1772d880-f70e-4771-9cb2-9a2396900da3; Hadjipavlou-Litina, D. (Dimitra)|||/items/dd63776c-cfdf-44f1-84a0-af7a042c2697; Ancizu, S. (Saioa)|||/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7; Villar, R. (Raquel)|||/items/8b76d05b-786e-4baa-8e1f-5d29011d72fd; Solano, B. (Beatriz)|||/items/f8ed6dbf-02f6-4dec-8dcc-af6680ab51e5; Moreno-de-Viguri, E. (Elsa)|||/items/08473f69-a6ab-4896-8cf9-41e6daf12bfa; Torres, E. (Enrique)|||/items/63f6c247-849f-4192-9a16-b86398ba3fc5; Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45; Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618; Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8

Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents

We report the synthesis, anti-inflammatory and antioxidant activities of novel quinoxaline and quinoxaline 1,4-di-N-oxide derivatives. Microwave assisted methods have been used in order to optimize reaction times and to improve the yields. The tested compounds presented important scavenging activiti...

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Detalles Bibliográficos
Autores:	Burguete, A. (Asunción)\|\|\|/items/841509d2-131f-45ab-97cb-0e072035c61e, Pontiki, E. (Eleni)\|\|\|/items/1772d880-f70e-4771-9cb2-9a2396900da3, Hadjipavlou-Litina, D. (Dimitra)\|\|\|/items/dd63776c-cfdf-44f1-84a0-af7a042c2697, Ancizu, S. (Saioa)\|\|\|/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7, Villar, R. (Raquel)\|\|\|/items/8b76d05b-786e-4baa-8e1f-5d29011d72fd, Solano, B. (Beatriz)\|\|\|/items/f8ed6dbf-02f6-4dec-8dcc-af6680ab51e5, Moreno-de-Viguri, E. (Elsa)\|\|\|/items/08473f69-a6ab-4896-8cf9-41e6daf12bfa, Torres, E. (Enrique)\|\|\|/items/63f6c247-849f-4192-9a16-b86398ba3fc5, Pérez-Silanes, S. (Silvia)\|\|\|/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45, Aldana, I. (Ignacio)\|\|\|/items/2a317afc-d6ab-4970-8bac-41d9715f5618, Monge, A. (Antonio)\|\|\|/items/804a350e-c7ff-4318-9742-cdc3432eb2a8
Tipo de recurso:	artículo
Fecha de publicación:	2011
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/18591
Acceso en línea:	https://hdl.handle.net/10171/18591
Access Level:	acceso abierto
Palabra clave:	Quinoxaline derivatives Anti-inflammatory agents 1,4-di-N-oxide derivatives Soybean lipoxygenase

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spelling	Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agentsBurguete, A. (Asunción)\|\|\|/items/841509d2-131f-45ab-97cb-0e072035c61ePontiki, E. (Eleni)\|\|\|/items/1772d880-f70e-4771-9cb2-9a2396900da3Hadjipavlou-Litina, D. (Dimitra)\|\|\|/items/dd63776c-cfdf-44f1-84a0-af7a042c2697Ancizu, S. (Saioa)\|\|\|/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7Villar, R. (Raquel)\|\|\|/items/8b76d05b-786e-4baa-8e1f-5d29011d72fdSolano, B. (Beatriz)\|\|\|/items/f8ed6dbf-02f6-4dec-8dcc-af6680ab51e5Moreno-de-Viguri, E. (Elsa)\|\|\|/items/08473f69-a6ab-4896-8cf9-41e6daf12bfaTorres, E. (Enrique)\|\|\|/items/63f6c247-849f-4192-9a16-b86398ba3fc5Pérez-Silanes, S. (Silvia)\|\|\|/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45Aldana, I. (Ignacio)\|\|\|/items/2a317afc-d6ab-4970-8bac-41d9715f5618Monge, A. (Antonio)\|\|\|/items/804a350e-c7ff-4318-9742-cdc3432eb2a8Quinoxaline derivativesAnti-inflammatory agents1,4-di-N-oxide derivativesSoybean lipoxygenaseWe report the synthesis, anti-inflammatory and antioxidant activities of novel quinoxaline and quinoxaline 1,4-di-N-oxide derivatives. Microwave assisted methods have been used in order to optimize reaction times and to improve the yields. The tested compounds presented important scavenging activities and promising in vitro inhibition of soybean lipoxygenase. Two of the best lipoxygenase inhibitors (compounds 7b and 8f) were evaluated as in vivo anti-inflammatory agents using the carrageenin-induced edema model. One of them (compound 7b) showed important in vivo anti-inflammatory effect (41%) similar to that of indomethacin (47%) used as the reference drug.Wiley-BlackwellDadun. Depósito Académico Digital Universidad de Navarra20112011-06-2120112011-01-0120112011-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/18591reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/185912026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents
title	Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents
spellingShingle	Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents Burguete, A. (Asunción)\|\|\|/items/841509d2-131f-45ab-97cb-0e072035c61e Quinoxaline derivatives Anti-inflammatory agents 1,4-di-N-oxide derivatives Soybean lipoxygenase
title_short	Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents
title_full	Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents
title_fullStr	Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents
title_full_unstemmed	Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents
title_sort	Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents
dc.creator.none.fl_str_mv	Burguete, A. (Asunción)\|\|\|/items/841509d2-131f-45ab-97cb-0e072035c61e Pontiki, E. (Eleni)\|\|\|/items/1772d880-f70e-4771-9cb2-9a2396900da3 Hadjipavlou-Litina, D. (Dimitra)\|\|\|/items/dd63776c-cfdf-44f1-84a0-af7a042c2697 Ancizu, S. (Saioa)\|\|\|/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7 Villar, R. (Raquel)\|\|\|/items/8b76d05b-786e-4baa-8e1f-5d29011d72fd Solano, B. (Beatriz)\|\|\|/items/f8ed6dbf-02f6-4dec-8dcc-af6680ab51e5 Moreno-de-Viguri, E. (Elsa)\|\|\|/items/08473f69-a6ab-4896-8cf9-41e6daf12bfa Torres, E. (Enrique)\|\|\|/items/63f6c247-849f-4192-9a16-b86398ba3fc5 Pérez-Silanes, S. (Silvia)\|\|\|/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 Aldana, I. (Ignacio)\|\|\|/items/2a317afc-d6ab-4970-8bac-41d9715f5618 Monge, A. (Antonio)\|\|\|/items/804a350e-c7ff-4318-9742-cdc3432eb2a8
author	Burguete, A. (Asunción)\|\|\|/items/841509d2-131f-45ab-97cb-0e072035c61e
author_facet	Burguete, A. (Asunción)\|\|\|/items/841509d2-131f-45ab-97cb-0e072035c61e Pontiki, E. (Eleni)\|\|\|/items/1772d880-f70e-4771-9cb2-9a2396900da3 Hadjipavlou-Litina, D. (Dimitra)\|\|\|/items/dd63776c-cfdf-44f1-84a0-af7a042c2697 Ancizu, S. (Saioa)\|\|\|/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7 Villar, R. (Raquel)\|\|\|/items/8b76d05b-786e-4baa-8e1f-5d29011d72fd Solano, B. (Beatriz)\|\|\|/items/f8ed6dbf-02f6-4dec-8dcc-af6680ab51e5 Moreno-de-Viguri, E. (Elsa)\|\|\|/items/08473f69-a6ab-4896-8cf9-41e6daf12bfa Torres, E. (Enrique)\|\|\|/items/63f6c247-849f-4192-9a16-b86398ba3fc5 Pérez-Silanes, S. (Silvia)\|\|\|/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 Aldana, I. (Ignacio)\|\|\|/items/2a317afc-d6ab-4970-8bac-41d9715f5618 Monge, A. (Antonio)\|\|\|/items/804a350e-c7ff-4318-9742-cdc3432eb2a8
author_role	author
author2	Pontiki, E. (Eleni)\|\|\|/items/1772d880-f70e-4771-9cb2-9a2396900da3 Hadjipavlou-Litina, D. (Dimitra)\|\|\|/items/dd63776c-cfdf-44f1-84a0-af7a042c2697 Ancizu, S. (Saioa)\|\|\|/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7 Villar, R. (Raquel)\|\|\|/items/8b76d05b-786e-4baa-8e1f-5d29011d72fd Solano, B. (Beatriz)\|\|\|/items/f8ed6dbf-02f6-4dec-8dcc-af6680ab51e5 Moreno-de-Viguri, E. (Elsa)\|\|\|/items/08473f69-a6ab-4896-8cf9-41e6daf12bfa Torres, E. (Enrique)\|\|\|/items/63f6c247-849f-4192-9a16-b86398ba3fc5 Pérez-Silanes, S. (Silvia)\|\|\|/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 Aldana, I. (Ignacio)\|\|\|/items/2a317afc-d6ab-4970-8bac-41d9715f5618 Monge, A. (Antonio)\|\|\|/items/804a350e-c7ff-4318-9742-cdc3432eb2a8
author2_role	author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Quinoxaline derivatives Anti-inflammatory agents 1,4-di-N-oxide derivatives Soybean lipoxygenase
topic	Quinoxaline derivatives Anti-inflammatory agents 1,4-di-N-oxide derivatives Soybean lipoxygenase
description	We report the synthesis, anti-inflammatory and antioxidant activities of novel quinoxaline and quinoxaline 1,4-di-N-oxide derivatives. Microwave assisted methods have been used in order to optimize reaction times and to improve the yields. The tested compounds presented important scavenging activities and promising in vitro inhibition of soybean lipoxygenase. Two of the best lipoxygenase inhibitors (compounds 7b and 8f) were evaluated as in vivo anti-inflammatory agents using the carrageenin-induced edema model. One of them (compound 7b) showed important in vivo anti-inflammatory effect (41%) similar to that of indomethacin (47%) used as the reference drug.
publishDate	2011
dc.date.none.fl_str_mv	2011 2011-06-21 2011 2011-01-01 2011 2011-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/18591
url	https://hdl.handle.net/10171/18591
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Wiley-Blackwell
publisher.none.fl_str_mv	Wiley-Blackwell
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.300719

Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents

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