Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents

We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of...

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Detalles Bibliográficos
Autores: Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618, Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8, Deharo, E. (Eric)|||/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9, Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45, Burguete, A. (Asunción)|||/items/841509d2-131f-45ab-97cb-0e072035c61e, Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd, Pabon, A. (Adriana)|||/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49, Gil-Royo, A.G. (Ana Gloria)|||/items/f54744d1-e54a-42e1-b5d0-cbabefd3fc53
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/35725
Acceso en línea:https://hdl.handle.net/10171/35725
Access Level:acceso abierto
Palabra clave:Chalcone
Quinoxaline 1,4-di-N-oxide
Quinoxaline
Antimalarial agents
Plasmodium falciparum
Descripción
Sumario:We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.

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