Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study

INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype a...

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Authors: Gómez Acebo, Inés, Dierssen Sotos, Trinidad, Palazuelos-Calderón, Camilo, Fernández Navarro, Pablo, Castaño-Vinyals, Gemma, Alonso Molero, Jéssica, Urtiaga, Carmen, Fernández Villa, Tania, Ardanaz, Eva, Riva del Fresno, Manuel, Molina Barceló, Ana, Jiménez Moleón, José Juan, García Martinez, Lidia, Amiano, Pilar, Rodriguez-Cundin, Paz, Moreno Aguado, Víctor, Pérez Gómez, Beatriz, Aragonès Sanz, Núria, Kogevinas, Manolis, Pollán, Marina, Llorca Díaz, Javier
Format: article
Status:Published version
Publication Date:2018
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/130561
Online Access:https://hdl.handle.net/2445/130561
Access Level:Open access
Keyword:Càncer de mama
Càncer de pròstata
Espanya
Fenotip
Breast cancer
Prostate cancer
Spain
Phenotype
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spelling Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain studyGómez Acebo, InésDierssen Sotos, TrinidadPalazuelos-Calderón, CamiloFernández Navarro, PabloCastaño-Vinyals, GemmaAlonso Molero, JéssicaUrtiaga, CarmenFernández Villa, TaniaArdanaz, EvaRiva del Fresno, ManuelMolina Barceló, AnaJiménez Moleón, José JuanGarcía Martinez, LidiaAmiano, PilarRodriguez-Cundin, PazMoreno Aguado, VíctorPérez Gómez, BeatrizAragonès Sanz, NúriaKogevinas, ManolisPollán, MarinaLlorca Díaz, JavierCàncer de mamaCàncer de pròstataEspanyaFenotipBreast cancerProstate cancerSpainPhenotypeINTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype-cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. RESULTS: The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. CONCLUSIONS: Phototype is not associated with breast or prostate cancer.Public Library of Science (PLoS)2019201920182019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/130561Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0201750PLoS One, 2018, vol. 13, num. 8, p. e0201750https://doi.org/10.1371/journal.pone.0201750cc-by (c) Gómez Acebo, Inés et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1305612026-05-29T05:05:01Z
dc.title.none.fl_str_mv Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study
title Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study
spellingShingle Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study
Gómez Acebo, Inés
Càncer de mama
Càncer de pròstata
Espanya
Fenotip
Breast cancer
Prostate cancer
Spain
Phenotype
title_short Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study
title_full Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study
title_fullStr Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study
title_full_unstemmed Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study
title_sort Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study
dc.creator.none.fl_str_mv Gómez Acebo, Inés
Dierssen Sotos, Trinidad
Palazuelos-Calderón, Camilo
Fernández Navarro, Pablo
Castaño-Vinyals, Gemma
Alonso Molero, Jéssica
Urtiaga, Carmen
Fernández Villa, Tania
Ardanaz, Eva
Riva del Fresno, Manuel
Molina Barceló, Ana
Jiménez Moleón, José Juan
García Martinez, Lidia
Amiano, Pilar
Rodriguez-Cundin, Paz
Moreno Aguado, Víctor
Pérez Gómez, Beatriz
Aragonès Sanz, Núria
Kogevinas, Manolis
Pollán, Marina
Llorca Díaz, Javier
author Gómez Acebo, Inés
author_facet Gómez Acebo, Inés
Dierssen Sotos, Trinidad
Palazuelos-Calderón, Camilo
Fernández Navarro, Pablo
Castaño-Vinyals, Gemma
Alonso Molero, Jéssica
Urtiaga, Carmen
Fernández Villa, Tania
Ardanaz, Eva
Riva del Fresno, Manuel
Molina Barceló, Ana
Jiménez Moleón, José Juan
García Martinez, Lidia
Amiano, Pilar
Rodriguez-Cundin, Paz
Moreno Aguado, Víctor
Pérez Gómez, Beatriz
Aragonès Sanz, Núria
Kogevinas, Manolis
Pollán, Marina
Llorca Díaz, Javier
author_role author
author2 Dierssen Sotos, Trinidad
Palazuelos-Calderón, Camilo
Fernández Navarro, Pablo
Castaño-Vinyals, Gemma
Alonso Molero, Jéssica
Urtiaga, Carmen
Fernández Villa, Tania
Ardanaz, Eva
Riva del Fresno, Manuel
Molina Barceló, Ana
Jiménez Moleón, José Juan
García Martinez, Lidia
Amiano, Pilar
Rodriguez-Cundin, Paz
Moreno Aguado, Víctor
Pérez Gómez, Beatriz
Aragonès Sanz, Núria
Kogevinas, Manolis
Pollán, Marina
Llorca Díaz, Javier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer de mama
Càncer de pròstata
Espanya
Fenotip
Breast cancer
Prostate cancer
Spain
Phenotype
topic Càncer de mama
Càncer de pròstata
Espanya
Fenotip
Breast cancer
Prostate cancer
Spain
Phenotype
description INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype-cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. RESULTS: The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. CONCLUSIONS: Phototype is not associated with breast or prostate cancer.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/130561
url https://hdl.handle.net/2445/130561
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0201750
PLoS One, 2018, vol. 13, num. 8, p. e0201750
https://doi.org/10.1371/journal.pone.0201750
dc.rights.none.fl_str_mv cc-by (c) Gómez Acebo, Inés et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Gómez Acebo, Inés et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411058886639616
score 15,812455

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