Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study

INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype a...

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Detalhes bibliográficos
Autores: Gómez Acebo, Inés, Dierssen Sotos, Trinidad, Palazuelos-Calderón, Camilo, Fernández Navarro, Pablo, Castaño-Vinyals, Gemma, Alonso Molero, Jéssica, Urtiaga, Carmen, Fernández Villa, Tania, Ardanaz, Eva, Riva del Fresno, Manuel, Molina Barceló, Ana, Jiménez Moleón, José Juan, García Martinez, Lidia, Amiano, Pilar, Rodriguez-Cundin, Paz, Moreno Aguado, Víctor, Pérez Gómez, Beatriz, Aragonès Sanz, Núria, Kogevinas, Manolis, Pollán, Marina, Llorca Díaz, Javier
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2018
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/130561
Acesso em linha:https://hdl.handle.net/2445/130561
Access Level:Acceso aberto
Palavra-chave:Càncer de mama
Càncer de pròstata
Espanya
Fenotip
Breast cancer
Prostate cancer
Spain
Phenotype
Descrição
Resumo:INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype-cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. RESULTS: The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. CONCLUSIONS: Phototype is not associated with breast or prostate cancer.

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