Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)

[EN] Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL...

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Autores: Palomar Cros, Anna, Straif, Kurt, Romaguera, Dora, Aragonés, Nuria, Castaño Vinyals, Gemma, Martín Sánchez, Vicente, Moreno González, Víctor, Gómez Acebo, Inés, Guevara, Marcela, Aizpurua, Amaia, Molina Barceló, Ana, Hernández Segura, Natalia, Obón Santacana, Mireia, Alonso Molero, Jessica, Burgui, Rosana, Amiano, Pilar, Pinto Carbó, Marina, Olmedo Requena, Rocio, Fernández Tardón, Guillermo, Santos Sánchez, Vanessa, Fernández de Larrea Baz, Nerea, Fernández Villa, Tania, Casabonne, Delphine, Dierssen Sotos, Trinidad, Ardanaz, Eva, Dorronsoro, Ane, Pollán, Marina, Kogevinas, Manolis, Lassale, Camille
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de León
Repositorio:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/21984
Acceso en línea:https://onlinelibrary.wiley.com/doi/10.1002/ijc.34577
https://hdl.handle.net/10612/21984
Access Level:acceso abierto
Palabra clave:Medicina. Salud
Artificial sweeteners
Aspartame
Cancer risk
Case-contro
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repository_id_str
spelling Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)Palomar Cros, AnnaStraif, KurtRomaguera, DoraAragonés, NuriaCastaño Vinyals, GemmaMartín Sánchez, VicenteMoreno González, VíctorGómez Acebo, InésGuevara, MarcelaAizpurua, AmaiaMolina Barceló, AnaHernández Segura, NataliaObón Santacana, MireiaAlonso Molero, JessicaBurgui, RosanaAmiano, PilarPinto Carbó, MarinaOlmedo Requena, RocioFernández Tardón, GuillermoSantos Sánchez, VanessaFernández de Larrea Baz, NereaFernández Villa, TaniaCasabonne, DelphineDierssen Sotos, TrinidadArdanaz, EvaDorronsoro, AnePollán, MarinaKogevinas, ManolisLassale, CamilleMedicina. SaludArtificial sweetenersAspartameCancer riskCase-contro[EN] Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (≥ third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR = 1.58, 95% CI 1.05-2.41, P trend = .03) and stomach cancer (OR = 2.27 [0.99-5.44], P trend = .06). High consumption of aspartame, was associated with stomach cancer (OR = 2.04 [0.7-5.4], P trend = .05), while a lower risk was observed for breast cancer (OR = 0.28 [0.08-0.83], P trend = .03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.SIAGAURConsejería de Salud of the Junta de AndalucíaConsejería de Sanidad de la Región de MurciaConselleria de Sanitat of the Generalitat ValencianaFundaci on Caja de Ahorros de AsturiasFundación Marqués de ValdecillaGeneralitat de CatalunyaICGC International Cancer Genome Consortium CLLJunta de Castilla y LeónWileyMedicina PreventivaFacultad de Ciencias de la Salud2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://onlinelibrary.wiley.com/doi/10.1002/ijc.34577https://hdl.handle.net/10612/21984reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Universidad de LeónIngléshttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/219842026-06-24T12:43:27Z
dc.title.none.fl_str_mv Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
title Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
spellingShingle Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
Palomar Cros, Anna
Medicina. Salud
Artificial sweeteners
Aspartame
Cancer risk
Case-contro
title_short Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
title_full Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
title_fullStr Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
title_full_unstemmed Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
title_sort Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
dc.creator.none.fl_str_mv Palomar Cros, Anna
Straif, Kurt
Romaguera, Dora
Aragonés, Nuria
Castaño Vinyals, Gemma
Martín Sánchez, Vicente
Moreno González, Víctor
Gómez Acebo, Inés
Guevara, Marcela
Aizpurua, Amaia
Molina Barceló, Ana
Hernández Segura, Natalia
Obón Santacana, Mireia
Alonso Molero, Jessica
Burgui, Rosana
Amiano, Pilar
Pinto Carbó, Marina
Olmedo Requena, Rocio
Fernández Tardón, Guillermo
Santos Sánchez, Vanessa
Fernández de Larrea Baz, Nerea
Fernández Villa, Tania
Casabonne, Delphine
Dierssen Sotos, Trinidad
Ardanaz, Eva
Dorronsoro, Ane
Pollán, Marina
Kogevinas, Manolis
Lassale, Camille
author Palomar Cros, Anna
author_facet Palomar Cros, Anna
Straif, Kurt
Romaguera, Dora
Aragonés, Nuria
Castaño Vinyals, Gemma
Martín Sánchez, Vicente
Moreno González, Víctor
Gómez Acebo, Inés
Guevara, Marcela
Aizpurua, Amaia
Molina Barceló, Ana
Hernández Segura, Natalia
Obón Santacana, Mireia
Alonso Molero, Jessica
Burgui, Rosana
Amiano, Pilar
Pinto Carbó, Marina
Olmedo Requena, Rocio
Fernández Tardón, Guillermo
Santos Sánchez, Vanessa
Fernández de Larrea Baz, Nerea
Fernández Villa, Tania
Casabonne, Delphine
Dierssen Sotos, Trinidad
Ardanaz, Eva
Dorronsoro, Ane
Pollán, Marina
Kogevinas, Manolis
Lassale, Camille
author_role author
author2 Straif, Kurt
Romaguera, Dora
Aragonés, Nuria
Castaño Vinyals, Gemma
Martín Sánchez, Vicente
Moreno González, Víctor
Gómez Acebo, Inés
Guevara, Marcela
Aizpurua, Amaia
Molina Barceló, Ana
Hernández Segura, Natalia
Obón Santacana, Mireia
Alonso Molero, Jessica
Burgui, Rosana
Amiano, Pilar
Pinto Carbó, Marina
Olmedo Requena, Rocio
Fernández Tardón, Guillermo
Santos Sánchez, Vanessa
Fernández de Larrea Baz, Nerea
Fernández Villa, Tania
Casabonne, Delphine
Dierssen Sotos, Trinidad
Ardanaz, Eva
Dorronsoro, Ane
Pollán, Marina
Kogevinas, Manolis
Lassale, Camille
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Medicina Preventiva
Facultad de Ciencias de la Salud
dc.subject.none.fl_str_mv Medicina. Salud
Artificial sweeteners
Aspartame
Cancer risk
Case-contro
topic Medicina. Salud
Artificial sweeteners
Aspartame
Cancer risk
Case-contro
description [EN] Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (≥ third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR = 1.58, 95% CI 1.05-2.41, P trend = .03) and stomach cancer (OR = 2.27 [0.99-5.44], P trend = .06). High consumption of aspartame, was associated with stomach cancer (OR = 2.04 [0.7-5.4], P trend = .05), while a lower risk was observed for breast cancer (OR = 0.28 [0.08-0.83], P trend = .03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://onlinelibrary.wiley.com/doi/10.1002/ijc.34577
https://hdl.handle.net/10612/21984
url https://onlinelibrary.wiley.com/doi/10.1002/ijc.34577
https://hdl.handle.net/10612/21984
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:BULERIA. Repositorio Institucional de la Universidad de León
instname:Universidad de León
instname_str Universidad de León
reponame_str BULERIA. Repositorio Institucional de la Universidad de León
collection BULERIA. Repositorio Institucional de la Universidad de León
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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