Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain)

Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cas...

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Detalles Bibliográficos
Autores: Palomar-Cros A, Straif K, Romaguera D, Aragonés N, Castaño-Vinyals G, Martin V, Moreno V, Gómez-Acebo I, Guevara M, Aizpurua A, Molina-Barceló A, Jiménez-Moleón JJ, Tardón A, Contreras-Llanes M, Marcos-Gragera R, Huerta JM, Pérez-Gómez B, Espinosa A, Hernández-Segura N, Obón-Santacana M, Alonso-Molero J, Burgui R, Amiano P, Pinto-Carbó M, Olmedo-Requena R, Fernández-Tardón G, Santos-Sánchez V, Fernández de Larrea-Baz N, Fernández-Villa T, Casabonne D, Dierssen-Sotos T, Ardanaz E, Dorronsoro A, Pollán M, Kogevinas M, Lassale C
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p15367
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/15367
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85162002355&doi=10.1002%2fijc.34577&partnerID=40&md5=79efcef1caa84e2babc22150a78f5987
Access Level:acceso abierto
Palabra clave:artificial sweeteners
aspartame
cancer risk
case-control
Descripción
Sumario:Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (<greater than or equal to> third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR=1.58, 95% CI 1.05-2.41, P trend=.03) and stomach cancer (OR=2.27 [0.99-5.44], P trend=.06). High consumption of aspartame, was associated with stomach cancer (OR=2.04 [0.7-5.4], P trend=.05), while a lower risk was observed for breast cancer (OR=0.28 [0.08-0.83], P trend=.03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.

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