Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis

Neuropsychiatric symptoms (NPS) have been recently addressed as risk factors of conversion to Alzheimer's disease (AD) and other dementia types in patients diagnosed with Mild Cognitive Impairment (MCI). Our aim was to determine profiles based on the prominent NPS in MCI patients and to explore...

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Autores: Roberto, N, Portella, MJ, Marquie, M, Alegret, M, Hernandez, I, Mauleon, A, Rosende-Roca, M, Abdelnour, C, de Antonio, EE, Gil, S, Tartari, JP, Vargas, L, Espinosa, A, Ortega, G, Perez-Cordon, A, Sanabria, A, Orellana, A, de Rojas, I, Moreno-Grau, S, Montrreal, L, Alarcon-Martin, E, Ruiz, A, Tarraga, L, Boada, M, Valero, S
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p4898
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4898
https://ddd.uab.cat/record/255367
Access Level:acceso abierto
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spelling Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysisRoberto, NPortella, MJMarquie, MAlegret, MHernandez, IMauleon, ARosende-Roca, MAbdelnour, Cde Antonio, EEGil, STartari, JPVargas, LEspinosa, AOrtega, GPerez-Cordon, ASanabria, AOrellana, Ade Rojas, IMoreno-Grau, SMontrreal, LAlarcon-Martin, ERuiz, ATarraga, LBoada, MValero, SNeuropsychiatric symptoms (NPS) have been recently addressed as risk factors of conversion to Alzheimer's disease (AD) and other dementia types in patients diagnosed with Mild Cognitive Impairment (MCI). Our aim was to determine profiles based on the prominent NPS in MCI patients and to explore the predictive value of these profiles on conversion to specific types of dementia. A total of 2137 MCI patients monitored in a memory clinic were included in the study. Four NPS profiles emerged (classes), which were defined by preeminent symptoms: Irritability, Apathy, Anxiety/Depression and Asymptomatic. Irritability and Apathy were predictors of conversion to dementia (HR =1.43 and 1.56, respectively). Anxiety/depression class showed no risk effect of conversion when compared to Asymptomatic class. Irritability class appeared as the most discriminant neuropsychiatric condition to identify non-AD converters (i.e., frontotemporal dementia, vascular dementia, Parkinson's disease and dementia with Lewy Bodies). The findings revealed that consistent subgroups of MCI patients could be identified among comorbid basal NPS. The preeminent NPS showed to behave differentially on conversion to dementia, beyond AD. Therefore, NPS should be used as early diagnosis facilitators, and should also guide clinicians to detect patients with different illness trajectories in the progression of MCI.NATURE RESEARCH2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4898https://ddd.uab.cat/record/255367Scientific ReportsISSN: 20452322reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p48982026-06-14T12:41:47Z
dc.title.none.fl_str_mv Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
title Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
spellingShingle Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
Roberto, N
title_short Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
title_full Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
title_fullStr Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
title_full_unstemmed Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
title_sort Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
dc.creator.none.fl_str_mv Roberto, N
Portella, MJ
Marquie, M
Alegret, M
Hernandez, I
Mauleon, A
Rosende-Roca, M
Abdelnour, C
de Antonio, EE
Gil, S
Tartari, JP
Vargas, L
Espinosa, A
Ortega, G
Perez-Cordon, A
Sanabria, A
Orellana, A
de Rojas, I
Moreno-Grau, S
Montrreal, L
Alarcon-Martin, E
Ruiz, A
Tarraga, L
Boada, M
Valero, S
author Roberto, N
author_facet Roberto, N
Portella, MJ
Marquie, M
Alegret, M
Hernandez, I
Mauleon, A
Rosende-Roca, M
Abdelnour, C
de Antonio, EE
Gil, S
Tartari, JP
Vargas, L
Espinosa, A
Ortega, G
Perez-Cordon, A
Sanabria, A
Orellana, A
de Rojas, I
Moreno-Grau, S
Montrreal, L
Alarcon-Martin, E
Ruiz, A
Tarraga, L
Boada, M
Valero, S
author_role author
author2 Portella, MJ
Marquie, M
Alegret, M
Hernandez, I
Mauleon, A
Rosende-Roca, M
Abdelnour, C
de Antonio, EE
Gil, S
Tartari, JP
Vargas, L
Espinosa, A
Ortega, G
Perez-Cordon, A
Sanabria, A
Orellana, A
de Rojas, I
Moreno-Grau, S
Montrreal, L
Alarcon-Martin, E
Ruiz, A
Tarraga, L
Boada, M
Valero, S
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
description Neuropsychiatric symptoms (NPS) have been recently addressed as risk factors of conversion to Alzheimer's disease (AD) and other dementia types in patients diagnosed with Mild Cognitive Impairment (MCI). Our aim was to determine profiles based on the prominent NPS in MCI patients and to explore the predictive value of these profiles on conversion to specific types of dementia. A total of 2137 MCI patients monitored in a memory clinic were included in the study. Four NPS profiles emerged (classes), which were defined by preeminent symptoms: Irritability, Apathy, Anxiety/Depression and Asymptomatic. Irritability and Apathy were predictors of conversion to dementia (HR =1.43 and 1.56, respectively). Anxiety/depression class showed no risk effect of conversion when compared to Asymptomatic class. Irritability class appeared as the most discriminant neuropsychiatric condition to identify non-AD converters (i.e., frontotemporal dementia, vascular dementia, Parkinson's disease and dementia with Lewy Bodies). The findings revealed that consistent subgroups of MCI patients could be identified among comorbid basal NPS. The preeminent NPS showed to behave differentially on conversion to dementia, beyond AD. Therefore, NPS should be used as early diagnosis facilitators, and should also guide clinicians to detect patients with different illness trajectories in the progression of MCI.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4898
https://ddd.uab.cat/record/255367
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4898
https://ddd.uab.cat/record/255367
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv NATURE RESEARCH
publisher.none.fl_str_mv NATURE RESEARCH
dc.source.none.fl_str_mv Scientific Reports
ISSN: 20452322
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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