Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis

Hidalgo-Tenorio, Carmen; Gálvez-Acebal, Juan; Martínez-Marcos, Francisco Javier; Plata-Ciezar, Antonio; Torre, Javier de la; López-Cortés, Luis Eduardo; Noureddine, Mariam; Reguera Iglesias, José María; Vinuesa García, David; García-López, María Victoria; Ojeda Burgos, Guillermo; Luque-Márquez, Rafael; Lomas-Cabezas, José Manuel; Lepe, José A.; Alarcón González, Arístides de

Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis

[Background] S. aureus (SA) infective endocarditis (IE) has a very high mortality, attributed to the age and comorbidities of patients, inadequate or delayed antibiotic treatment, and methicillin resistance, among other causes. The main study objective was to analyze epidemiological and clinical dif...

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Autores:	Hidalgo-Tenorio, Carmen, Gálvez-Acebal, Juan, Martínez-Marcos, Francisco Javier, Plata-Ciezar, Antonio, Torre, Javier de la, López-Cortés, Luis Eduardo, Noureddine, Mariam, Reguera Iglesias, José María, Vinuesa García, David, García-López, María Victoria, Ojeda Burgos, Guillermo, Luque-Márquez, Rafael, Lomas-Cabezas, José Manuel, Lepe, José A., Alarcón González, Arístides de
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2020
País:	España
Institución:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:	oai:digital.csic.es:10261/236486
Acceso en línea:	http://hdl.handle.net/10261/236486
Access Level:	acceso abierto
Palabra clave:	Endocarditis Staphylococcus aureus Vancomycin Methicillin resistance

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spelling	Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditisHidalgo-Tenorio, CarmenGálvez-Acebal, JuanMartínez-Marcos, Francisco JavierPlata-Ciezar, AntonioTorre, Javier de laLópez-Cortés, Luis EduardoNoureddine, MariamReguera Iglesias, José MaríaVinuesa García, DavidGarcía-López, María VictoriaOjeda Burgos, GuillermoLuque-Márquez, RafaelLomas-Cabezas, José ManuelLepe, José A.Alarcón González, Arístides deEndocarditisStaphylococcus aureusVancomycinMethicillin resistance[Background] S. aureus (SA) infective endocarditis (IE) has a very high mortality, attributed to the age and comorbidities of patients, inadequate or delayed antibiotic treatment, and methicillin resistance, among other causes. The main study objective was to analyze epidemiological and clinical differences between IE by methicillin-resistant versus methicillin-susceptible SA (MRSA vs. MSSA) and to examine prognostic factors for SA endocarditis, including methicillin resistance and vancomycin minimum inhibitory concentration (MIC) values > 1 μg/mL to MRSA.[Methods] Patients with SA endocarditis were consecutively and prospectively recruited from the Andalusia endocarditis cohort between 1984 and January 2017.[Results] We studied 437 patients with SA endocarditis, which was MRSA in 13.5% of cases. A greater likelihood of history of COPD (OR 3.19; 95% CI 1.41–7.23), invasive procedures, or recognized infection focus in the 3 months before IE onset (OR 2.9; 95% CI 1.14–7.65) and of diagnostic delay (OR 3.94; 95% CI 1.64–9.5) was observed in patients with MRSA versus MSSA endocarditis. The one-year mortality rate due to SA endocarditis was 44.3% and associated with decade of endocarditis onset (1985–1999) (OR 8.391; 95% CI (2.82–24.9); 2000–2009 (OR 6.4; 95% CI 2.92–14.06); active neoplasm (OR 6.63; 95% CI 1.7–25.5) and sepsis (OR 2.28; 95% CI 1.053–4.9). Methicillin resistance was not associated with higher IE-related mortality (49.7 vs. 43.1%; p = 0.32).[Conclusion] MRSA IE is associated with COPD, previous invasive procedure or recognized infection focus, and nosocomial or healthcare-related origin. Methicillin resistance does not appear to be a decisive prognostic factor for SA IE.BioMed CentralConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/236486reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://doi.org/10.1186/s12879-020-4895-1Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2364862026-05-22T06:33:51Z
dc.title.none.fl_str_mv	Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis
title	Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis
spellingShingle	Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis Hidalgo-Tenorio, Carmen Endocarditis Staphylococcus aureus Vancomycin Methicillin resistance
title_short	Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis
title_full	Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis
title_fullStr	Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis
title_full_unstemmed	Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis
title_sort	Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis
dc.creator.none.fl_str_mv	Hidalgo-Tenorio, Carmen Gálvez-Acebal, Juan Martínez-Marcos, Francisco Javier Plata-Ciezar, Antonio Torre, Javier de la López-Cortés, Luis Eduardo Noureddine, Mariam Reguera Iglesias, José María Vinuesa García, David García-López, María Victoria Ojeda Burgos, Guillermo Luque-Márquez, Rafael Lomas-Cabezas, José Manuel Lepe, José A. Alarcón González, Arístides de
author	Hidalgo-Tenorio, Carmen
author_facet	Hidalgo-Tenorio, Carmen Gálvez-Acebal, Juan Martínez-Marcos, Francisco Javier Plata-Ciezar, Antonio Torre, Javier de la López-Cortés, Luis Eduardo Noureddine, Mariam Reguera Iglesias, José María Vinuesa García, David García-López, María Victoria Ojeda Burgos, Guillermo Luque-Márquez, Rafael Lomas-Cabezas, José Manuel Lepe, José A. Alarcón González, Arístides de
author_role	author
author2	Gálvez-Acebal, Juan Martínez-Marcos, Francisco Javier Plata-Ciezar, Antonio Torre, Javier de la López-Cortés, Luis Eduardo Noureddine, Mariam Reguera Iglesias, José María Vinuesa García, David García-López, María Victoria Ojeda Burgos, Guillermo Luque-Márquez, Rafael Lomas-Cabezas, José Manuel Lepe, José A. Alarcón González, Arístides de
author2_role	author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv	Endocarditis Staphylococcus aureus Vancomycin Methicillin resistance
topic	Endocarditis Staphylococcus aureus Vancomycin Methicillin resistance
description	[Background] S. aureus (SA) infective endocarditis (IE) has a very high mortality, attributed to the age and comorbidities of patients, inadequate or delayed antibiotic treatment, and methicillin resistance, among other causes. The main study objective was to analyze epidemiological and clinical differences between IE by methicillin-resistant versus methicillin-susceptible SA (MRSA vs. MSSA) and to examine prognostic factors for SA endocarditis, including methicillin resistance and vancomycin minimum inhibitory concentration (MIC) values > 1 μg/mL to MRSA.
publishDate	2020
dc.date.none.fl_str_mv	2020 2021 2021 2021
dc.type.none.fl_str_mv	info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10261/236486
url	http://hdl.handle.net/10261/236486
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	http://doi.org/10.1186/s12879-020-4895-1 Sí
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	BioMed Central
publisher.none.fl_str_mv	BioMed Central
dc.source.none.fl_str_mv	reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str	DIGITAL.CSIC. Repositorio Institucional del CSIC
collection	DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,811543

Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis

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