Basolateral amygdala-ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive-compulsive disorder

Background: cognitive behavioural therapy (CBT), including exposure and ritual prevention, is a first-line treatment for obsessive-compulsive disorder (OCD), but few reliable predictors of CBT outcome have been identified. Based on research in animal models, we hypothesized that individual differenc...

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Autores: Fullana Rivas, Miguel Àngel, Zhu, Xi, Alonso Ortega, María del Pino, Cardoner, N. (Narcís), Real, Eva, López Solà, Clara, Segalàs Cosi, Cinto, Subirà Coromina, Marta, Galfalvy, Hanga, Menchón Magriñá, José Manuel, Simpson, Helen Blair, Marsh, Rachel, Soriano Mas, Carles
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/156819
Acceso en línea:https://hdl.handle.net/2445/156819
Access Level:acceso abierto
Palabra clave:Diagnòstic per la imatge
Teràpia cognitiva
Imatges per ressonància magnètica
Neurosi obsessiva
Escorça frontal
Diagnostic imaging
Cognitive therapy
Magnetic resonance imaging
Obsessive-compulsive disorder
Prefrontal cortex
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spelling Basolateral amygdala-ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive-compulsive disorderFullana Rivas, Miguel ÀngelZhu, XiAlonso Ortega, María del PinoCardoner, N. (Narcís)Real, EvaLópez Solà, ClaraSegalàs Cosi, CintoSubirà Coromina, MartaGalfalvy, HangaMenchón Magriñá, José ManuelSimpson, Helen BlairMarsh, RachelSoriano Mas, CarlesDiagnòstic per la imatgeTeràpia cognitivaImatges per ressonància magnèticaNeurosi obsessivaEscorça frontalDiagnostic imagingCognitive therapyMagnetic resonance imagingObsessive-compulsive disorderPrefrontal cortexBackground: cognitive behavioural therapy (CBT), including exposure and ritual prevention, is a first-line treatment for obsessive-compulsive disorder (OCD), but few reliable predictors of CBT outcome have been identified. Based on research in animal models, we hypothesized that individual differences in basolateral amygdala-ventromedial prefrontal cortex (BLA-vmPFC) communication would predict CBT outcome in patients with OCD. Methods: we investigated whether BLA-vmPFC resting-state functional connectivity (rs-fc) predicts CBT outcome in patients with OCD. We assessed BLA-vmPFC rs-fc in patients with OCD on a stable dose of a selective serotonin reuptake inhibitor who then received CBT and in healthy control participants. Results: we included 73 patients with OCD and 84 healthy controls in our study. Decreased BLA-vmPFC rs-fc predicted a better CBT outcome in patients with OCD and was also detected in those with OCD compared with healthy participants. Additional analyses revealed that decreased BLA-vmPFC rs-fc uniquely characterized the patients with OCD who responded to CBT. Limitations: we used a sample of convenience, and all patients were receiving pharmacological treatment for OCD. Conclusion: in this large sample of patients with OCD, BLA-vmPFC functional connectivity predicted CBT outcome. These results suggest that future research should investigate the potential of BLA-vmPFC pathways to inform treatment selection for CBT across patients with OCD and anxiety disorders.Canadian Medical Association2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/156819Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1503/jpn.160215Journal of Psychiatry & Neuroscience, 2017, vol. 42, num. 6, p. 378-385https://doi.org/10.1503/jpn.160215(c) Fullana, Miquel A. et al., 2017info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1568192026-05-27T06:46:51Z
dc.title.none.fl_str_mv Basolateral amygdala-ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive-compulsive disorder
title Basolateral amygdala-ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive-compulsive disorder
spellingShingle Basolateral amygdala-ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive-compulsive disorder
Fullana Rivas, Miguel Àngel
Diagnòstic per la imatge
Teràpia cognitiva
Imatges per ressonància magnètica
Neurosi obsessiva
Escorça frontal
Diagnostic imaging
Cognitive therapy
Magnetic resonance imaging
Obsessive-compulsive disorder
Prefrontal cortex
title_short Basolateral amygdala-ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive-compulsive disorder
title_full Basolateral amygdala-ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive-compulsive disorder
title_fullStr Basolateral amygdala-ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive-compulsive disorder
title_full_unstemmed Basolateral amygdala-ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive-compulsive disorder
title_sort Basolateral amygdala-ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive-compulsive disorder
dc.creator.none.fl_str_mv Fullana Rivas, Miguel Àngel
Zhu, Xi
Alonso Ortega, María del Pino
Cardoner, N. (Narcís)
Real, Eva
López Solà, Clara
Segalàs Cosi, Cinto
Subirà Coromina, Marta
Galfalvy, Hanga
Menchón Magriñá, José Manuel
Simpson, Helen Blair
Marsh, Rachel
Soriano Mas, Carles
author Fullana Rivas, Miguel Àngel
author_facet Fullana Rivas, Miguel Àngel
Zhu, Xi
Alonso Ortega, María del Pino
Cardoner, N. (Narcís)
Real, Eva
López Solà, Clara
Segalàs Cosi, Cinto
Subirà Coromina, Marta
Galfalvy, Hanga
Menchón Magriñá, José Manuel
Simpson, Helen Blair
Marsh, Rachel
Soriano Mas, Carles
author_role author
author2 Zhu, Xi
Alonso Ortega, María del Pino
Cardoner, N. (Narcís)
Real, Eva
López Solà, Clara
Segalàs Cosi, Cinto
Subirà Coromina, Marta
Galfalvy, Hanga
Menchón Magriñá, José Manuel
Simpson, Helen Blair
Marsh, Rachel
Soriano Mas, Carles
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Diagnòstic per la imatge
Teràpia cognitiva
Imatges per ressonància magnètica
Neurosi obsessiva
Escorça frontal
Diagnostic imaging
Cognitive therapy
Magnetic resonance imaging
Obsessive-compulsive disorder
Prefrontal cortex
topic Diagnòstic per la imatge
Teràpia cognitiva
Imatges per ressonància magnètica
Neurosi obsessiva
Escorça frontal
Diagnostic imaging
Cognitive therapy
Magnetic resonance imaging
Obsessive-compulsive disorder
Prefrontal cortex
description Background: cognitive behavioural therapy (CBT), including exposure and ritual prevention, is a first-line treatment for obsessive-compulsive disorder (OCD), but few reliable predictors of CBT outcome have been identified. Based on research in animal models, we hypothesized that individual differences in basolateral amygdala-ventromedial prefrontal cortex (BLA-vmPFC) communication would predict CBT outcome in patients with OCD. Methods: we investigated whether BLA-vmPFC resting-state functional connectivity (rs-fc) predicts CBT outcome in patients with OCD. We assessed BLA-vmPFC rs-fc in patients with OCD on a stable dose of a selective serotonin reuptake inhibitor who then received CBT and in healthy control participants. Results: we included 73 patients with OCD and 84 healthy controls in our study. Decreased BLA-vmPFC rs-fc predicted a better CBT outcome in patients with OCD and was also detected in those with OCD compared with healthy participants. Additional analyses revealed that decreased BLA-vmPFC rs-fc uniquely characterized the patients with OCD who responded to CBT. Limitations: we used a sample of convenience, and all patients were receiving pharmacological treatment for OCD. Conclusion: in this large sample of patients with OCD, BLA-vmPFC functional connectivity predicted CBT outcome. These results suggest that future research should investigate the potential of BLA-vmPFC pathways to inform treatment selection for CBT across patients with OCD and anxiety disorders.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/156819
url https://hdl.handle.net/2445/156819
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1503/jpn.160215
Journal of Psychiatry & Neuroscience, 2017, vol. 42, num. 6, p. 378-385
https://doi.org/10.1503/jpn.160215
dc.rights.none.fl_str_mv (c) Fullana, Miquel A. et al., 2017
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Fullana, Miquel A. et al., 2017
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Canadian Medical Association
publisher.none.fl_str_mv Canadian Medical Association
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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