Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy

Objective To evaluate the impact of low-dose aspirin (LDA) on placental size and uterine artery pulsatility index (UtA-PI) by analyzing longitudinal changes between the first and second trimesters in pregnancies at high risk for early-onset pre-eclampsia (PE).Methods This was a prospective observati...

Descripción completa

Detalles Bibliográficos
Autores: Trilla, C, Platero, J, Mora, J, Nan, MN, Medina, C, Alejos, O, Parra, J, Llurba, E
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p20490
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20490
Access Level:acceso abierto
Palabra clave:first trimester
low-dose aspirin
placental biometry
placental volume
pre-eclampsia
three-dimensional ultrasound
two-dimensional ultrasound
uterine artery Doppler
id ES_754c879faba931dfeb22cd751e655d58
oai_identifier_str oai:iibsantpau.fundanetsuite.com:p20490
network_acronym_str ES
network_name_str España
repository_id_str
spelling Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancyTrilla, CPlatero, JMora, JNan, MNMedina, CAlejos, OParra, JLlurba, Efirst trimesterlow-dose aspirinplacental biometryplacental volumepre-eclampsiathree-dimensional ultrasoundtwo-dimensional ultrasounduterine artery DopplerObjective To evaluate the impact of low-dose aspirin (LDA) on placental size and uterine artery pulsatility index (UtA-PI) by analyzing longitudinal changes between the first and second trimesters in pregnancies at high risk for early-onset pre-eclampsia (PE).Methods This was a prospective observational cohort study of 631 singleton pregnancies. Women at high risk of early-onset PE (delivery <= 33 + 6 weeks) were identified using maternal factors or a multivariate screening protocol and were prescribed LDA. Placental size was assessed using two- and three-dimensional ultrasonography, and UtA-PI was measured using transabdominal Doppler, with measurements obtained in the first and second trimesters. Differences in placental measurements and UtA-PI between high-risk women receiving LDA and low-risk untreated women were analyzed.Results Among the 631 participants, 53 (8.4%) women were prescribed LDA for the prevention of early-onset PE. Placental size in the first trimester was significantly smaller in the LDA group compared with the untreated group, as exemplified by placental volume (mean +/- SD, 68.46 +/- 25.19 cm3 vs 76.31 +/- 23.63 cm3; P = 0.022), and this trend persisted into the second trimester. However, no significant differences in placental growth from the first to the second trimester were observed between the groups. UtA-PI was significantly higher in the LDA group in both trimesters, but a greater decrease in UtA-PI multiples of the median values between trimesters was noted in these women (mean +/- SD, -14.0 +/- 0.28% vs -4.5 +/- 0.31%; P = 0.021). Perinatal outcomes were similar between the groups, with the exception of a higher rate of Cesarean delivery in the LDA group (38.5% vs 21.1%; P = 0.008).Conclusions Women at high risk for early-onset PE have a smaller placenta and higher UtA-PI in the first and second trimesters. Treatment of high-risk women with LDA did not affect placental growth but was associated with a greater reduction in UtA-PI, suggesting a positive effect of LDA on placental perfusion. These findings provide insight into the mechanism of action of LDA in the prevention of PE. (c) 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.WILEY2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20490ULTRASOUND IN OBSTETRICS & GYNECOLOGYISSN: 09607692ISSNe: 14690705reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p204902026-06-14T12:41:47Z
dc.title.none.fl_str_mv Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy
title Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy
spellingShingle Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy
Trilla, C
first trimester
low-dose aspirin
placental biometry
placental volume
pre-eclampsia
three-dimensional ultrasound
two-dimensional ultrasound
uterine artery Doppler
title_short Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy
title_full Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy
title_fullStr Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy
title_full_unstemmed Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy
title_sort Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy
dc.creator.none.fl_str_mv Trilla, C
Platero, J
Mora, J
Nan, MN
Medina, C
Alejos, O
Parra, J
Llurba, E
author Trilla, C
author_facet Trilla, C
Platero, J
Mora, J
Nan, MN
Medina, C
Alejos, O
Parra, J
Llurba, E
author_role author
author2 Platero, J
Mora, J
Nan, MN
Medina, C
Alejos, O
Parra, J
Llurba, E
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv first trimester
low-dose aspirin
placental biometry
placental volume
pre-eclampsia
three-dimensional ultrasound
two-dimensional ultrasound
uterine artery Doppler
topic first trimester
low-dose aspirin
placental biometry
placental volume
pre-eclampsia
three-dimensional ultrasound
two-dimensional ultrasound
uterine artery Doppler
description Objective To evaluate the impact of low-dose aspirin (LDA) on placental size and uterine artery pulsatility index (UtA-PI) by analyzing longitudinal changes between the first and second trimesters in pregnancies at high risk for early-onset pre-eclampsia (PE).Methods This was a prospective observational cohort study of 631 singleton pregnancies. Women at high risk of early-onset PE (delivery <= 33 + 6 weeks) were identified using maternal factors or a multivariate screening protocol and were prescribed LDA. Placental size was assessed using two- and three-dimensional ultrasonography, and UtA-PI was measured using transabdominal Doppler, with measurements obtained in the first and second trimesters. Differences in placental measurements and UtA-PI between high-risk women receiving LDA and low-risk untreated women were analyzed.Results Among the 631 participants, 53 (8.4%) women were prescribed LDA for the prevention of early-onset PE. Placental size in the first trimester was significantly smaller in the LDA group compared with the untreated group, as exemplified by placental volume (mean +/- SD, 68.46 +/- 25.19 cm3 vs 76.31 +/- 23.63 cm3; P = 0.022), and this trend persisted into the second trimester. However, no significant differences in placental growth from the first to the second trimester were observed between the groups. UtA-PI was significantly higher in the LDA group in both trimesters, but a greater decrease in UtA-PI multiples of the median values between trimesters was noted in these women (mean +/- SD, -14.0 +/- 0.28% vs -4.5 +/- 0.31%; P = 0.021). Perinatal outcomes were similar between the groups, with the exception of a higher rate of Cesarean delivery in the LDA group (38.5% vs 21.1%; P = 0.008).Conclusions Women at high risk for early-onset PE have a smaller placenta and higher UtA-PI in the first and second trimesters. Treatment of high-risk women with LDA did not affect placental growth but was associated with a greater reduction in UtA-PI, suggesting a positive effect of LDA on placental perfusion. These findings provide insight into the mechanism of action of LDA in the prevention of PE. (c) 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20490
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20490
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv ULTRASOUND IN OBSTETRICS & GYNECOLOGY
ISSN: 09607692
ISSNe: 14690705
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410970478051328
score 15.811543

Similares en LA Referencia