Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy
To evaluate the impact of low-dose aspirin (LDA) on placental size and uterine artery pulsatility index (UtA-PI) by analyzing longitudinal changes between the first and second trimesters in pregnancies at high risk for early-onset pre-eclampsia (PE). This was a prospective observational cohort study...
| Autores: | , , , , , , , |
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| Formato: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:uabarcelona_::ba8d1ab0628d4cf28ab9a7b665938153 |
| Acesso em linha: | https://ddd.uab.cat/record/327989 https://dx.doi.org/urn:doi:10.1002/uog.70095 |
| Access Level: | acceso abierto |
| Palavra-chave: | First trimester Low-dose aspirin Placental biometry Placental volume Pre-eclampsia Three-dimensional ultrasound Two-dimensional ultrasound uterine artery Doppler |
| Resumo: | To evaluate the impact of low-dose aspirin (LDA) on placental size and uterine artery pulsatility index (UtA-PI) by analyzing longitudinal changes between the first and second trimesters in pregnancies at high risk for early-onset pre-eclampsia (PE). This was a prospective observational cohort study of 631 singleton pregnancies. Women at high risk of early-onset PE (delivery ≤ 33 + 6 weeks) were identified using maternal factors or a multivariate screening protocol and were prescribed LDA. Placental size was assessed using two- and three-dimensional ultrasonography, and UtA-PI was measured using transabdominal Doppler, with measurements obtained in the first and second trimesters. Differences in placental measurements and UtA-PI between high-risk women receiving LDA and low-risk untreated women were analyzed. Among the 631 participants, 53 (8.4%) women were prescribed LDA for the prevention of early-onset PE. Placental size in the first trimester was significantly smaller in the LDA group compared with the untreated group, as exemplified by placental volume (mean ± SD, 68.46 ± 25.19 cm 3 vs 76.31 ± 23.63 cm 3 ; P = 0.022), and this trend persisted into the second trimester. However, no significant differences in placental growth from the first to the second trimester were observed between the groups. UtA-PI was significantly higher in the LDA group in both trimesters, but a greater decrease in UtA-PI multiples of the median values between trimesters was noted in these women (mean ± SD, -14.0 ± 0.28% vs -4.5 ± 0.31%; P = 0.021). Perinatal outcomes were similar between the groups, with the exception of a higher rate of Cesarean delivery in the LDA group (38.5% vs 21.1%; P = 0.008). Women at high risk for early-onset PE have a smaller placenta and higher UtA-PI in the first and second trimesters. Treatment of high-risk women with LDA did not affect placental growth but was associated with a greater reduction in UtA-PI, suggesting a positive effect of LDA on placental perfusion. These findings provide insight into the mechanism of action of LDA in the prevention of PE. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. |
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