Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming

Snakebite envenoming is a global neglected disease with an incidence of up to 2.7 million new cases every year. Although antivenoms are so-far the most effective treatment to reverse the acute systemic effects induced by snakebite envenoming, they have a limited therapeutic potential, being unable t...

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Authors: Sanchez-Castro, Eduardo E., Pajuelo-Reyes, Cecilia, Tejedo, Rebeca, Soria-Juan, Bárbara, Tapia-Limonchi, Rafael, Andreu, Enrique, Hitos, Ana B., Martín, Franz, Cahuana, Gladys M., Guerra-Duarte, Clara, Silva de Assis, H.C., Bedoya Bergua, Francisco Javier, Soria Escoms, Bernat, Chávez-Olórtegui, Carlos, Tejedo Huamán, Juan Rigoberto
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/269962
Online Access:http://hdl.handle.net/10261/269962
Access Level:Open access
Keyword:Advanced therapy medicinal products
Mesenchymal stromal cells
Snakebite
Envenoming
Muscle regeneration
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spelling Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite EnvenomingSanchez-Castro, Eduardo E.Pajuelo-Reyes, CeciliaTejedo, RebecaSoria-Juan, BárbaraTapia-Limonchi, RafaelAndreu, EnriqueHitos, Ana B.Martín, FranzCahuana, Gladys M.Guerra-Duarte, ClaraSilva de Assis, H.C.Bedoya Bergua, Francisco JavierSoria Escoms, BernatChávez-Olórtegui, CarlosTejedo Huamán, Juan RigobertoAdvanced therapy medicinal productsMesenchymal stromal cellsSnakebiteEnvenomingMuscle regenerationSnakebite envenoming is a global neglected disease with an incidence of up to 2.7 million new cases every year. Although antivenoms are so-far the most effective treatment to reverse the acute systemic effects induced by snakebite envenoming, they have a limited therapeutic potential, being unable to completely neutralize the local venom effects. Local damage, such as dermonecrosis and myonecrosis, can lead to permanent sequelae with physical, social, and psychological implications. The strong inflammatory process induced by snake venoms is associated with poor tissue regeneration, in particular the lack of or reduced skeletal muscle regeneration. Mesenchymal stromal cells (MSCs)-based therapies have shown both anti-inflammatory and pro-regenerative properties. We postulate that using allogeneic MSCs or their cell-free products can induce skeletal muscle regeneration in snakebite victims, improving all the three steps of the skeletal muscle regeneration process, mainly by anti-inflammatory activity, paracrine effects, neovascularization induction, and inhibition of tissue damage, instrumental for microenvironment remodeling and regeneration. Since snakebite envenoming occurs mainly in areas with poor healthcare, we enlist the principles and potential of MSCs-based therapies and discuss regulatory issues, good manufacturing practices, transportation, storage, and related-procedures that could allow the administration of these therapies, looking forward to a safe and cost-effective treatment for a so far unsolved and neglected health problem.The authors are supported by the University Pablo de Olavide (Sevilla), the University Miguel Hernández (Elche, Alicante), National University Toribio Rodriguez de Mendoza (Chachapoyas, Peru) Grants: Contrato N° 09-2019-FONDECYT-BM-INC.INV to JRT, JDRF 2-SRA-2019-837-S-B and AVI-GVA COVID-19-68 to BS, Fundación Andaluza de I+D and Al-Andalus Biopharma Project (FAID-2018-1). The authors CC-O, CG-D, and TCSA were supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil (CNPq) (Process: 406163/2018-9), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil - CAPES (Program COFECUB Process: 88881.191812/2018-01) and by Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Brazil (FAPEMIG).Frontiers MediaUniversidad Pablo de OlavideUniversidad Miguel HernándezUniversidad Nacional Toribio Rodríguez de Mendoza de AmazonasFondo Nacional de Desarrollo Científico y Tecnológico (Chile)Fundación Andaluza de Investigación y DesarrolloConselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil)Fundação de Amparo à Pesquisa do Estado de São Paulo Minas GeraisConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/269962reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3389/fimmu.2020.609961Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2699622026-05-22T06:33:51Z
dc.title.none.fl_str_mv Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming
title Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming
spellingShingle Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming
Sanchez-Castro, Eduardo E.
Advanced therapy medicinal products
Mesenchymal stromal cells
Snakebite
Envenoming
Muscle regeneration
title_short Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming
title_full Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming
title_fullStr Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming
title_full_unstemmed Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming
title_sort Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming
dc.creator.none.fl_str_mv Sanchez-Castro, Eduardo E.
Pajuelo-Reyes, Cecilia
Tejedo, Rebeca
Soria-Juan, Bárbara
Tapia-Limonchi, Rafael
Andreu, Enrique
Hitos, Ana B.
Martín, Franz
Cahuana, Gladys M.
Guerra-Duarte, Clara
Silva de Assis, H.C.
Bedoya Bergua, Francisco Javier
Soria Escoms, Bernat
Chávez-Olórtegui, Carlos
Tejedo Huamán, Juan Rigoberto
author Sanchez-Castro, Eduardo E.
author_facet Sanchez-Castro, Eduardo E.
Pajuelo-Reyes, Cecilia
Tejedo, Rebeca
Soria-Juan, Bárbara
Tapia-Limonchi, Rafael
Andreu, Enrique
Hitos, Ana B.
Martín, Franz
Cahuana, Gladys M.
Guerra-Duarte, Clara
Silva de Assis, H.C.
Bedoya Bergua, Francisco Javier
Soria Escoms, Bernat
Chávez-Olórtegui, Carlos
Tejedo Huamán, Juan Rigoberto
author_role author
author2 Pajuelo-Reyes, Cecilia
Tejedo, Rebeca
Soria-Juan, Bárbara
Tapia-Limonchi, Rafael
Andreu, Enrique
Hitos, Ana B.
Martín, Franz
Cahuana, Gladys M.
Guerra-Duarte, Clara
Silva de Assis, H.C.
Bedoya Bergua, Francisco Javier
Soria Escoms, Bernat
Chávez-Olórtegui, Carlos
Tejedo Huamán, Juan Rigoberto
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Pablo de Olavide
Universidad Miguel Hernández
Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas
Fondo Nacional de Desarrollo Científico y Tecnológico (Chile)
Fundación Andaluza de Investigación y Desarrollo
Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil)
Fundação de Amparo à Pesquisa do Estado de São Paulo Minas Gerais
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Advanced therapy medicinal products
Mesenchymal stromal cells
Snakebite
Envenoming
Muscle regeneration
topic Advanced therapy medicinal products
Mesenchymal stromal cells
Snakebite
Envenoming
Muscle regeneration
description Snakebite envenoming is a global neglected disease with an incidence of up to 2.7 million new cases every year. Although antivenoms are so-far the most effective treatment to reverse the acute systemic effects induced by snakebite envenoming, they have a limited therapeutic potential, being unable to completely neutralize the local venom effects. Local damage, such as dermonecrosis and myonecrosis, can lead to permanent sequelae with physical, social, and psychological implications. The strong inflammatory process induced by snake venoms is associated with poor tissue regeneration, in particular the lack of or reduced skeletal muscle regeneration. Mesenchymal stromal cells (MSCs)-based therapies have shown both anti-inflammatory and pro-regenerative properties. We postulate that using allogeneic MSCs or their cell-free products can induce skeletal muscle regeneration in snakebite victims, improving all the three steps of the skeletal muscle regeneration process, mainly by anti-inflammatory activity, paracrine effects, neovascularization induction, and inhibition of tissue damage, instrumental for microenvironment remodeling and regeneration. Since snakebite envenoming occurs mainly in areas with poor healthcare, we enlist the principles and potential of MSCs-based therapies and discuss regulatory issues, good manufacturing practices, transportation, storage, and related-procedures that could allow the administration of these therapies, looking forward to a safe and cost-effective treatment for a so far unsolved and neglected health problem.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/269962
url http://hdl.handle.net/10261/269962
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3389/fimmu.2020.609961
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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