Brain activity changes with emotional words in different stages of psychosis.

BACKGROUND: To date, a large number of functional magnetic resonance imaging (fMRI) studies have been conducted on psychosis. However, little is known about changes in brain functioning in psychotic patients using an emotional auditory paradigm at different stages of the disease. Such knowledge is i...

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Autores: Soldevila-Matias, Pau, Garcia-Marti, Gracian, Fuentes-Dura, Inmaculada, Ruiz, Juan Carlos, Gonzalez-Navarro, Laura, Gonzalez-Vivas, Carlos, Radua, Joaquim, Sanjuan, Julio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p16955
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/16955
Access Level:acceso abierto
Palabra clave:Auditory paradigm
FEP patients
Neuroimaging fMRI
chronic psychosis patients
emotional design model
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spelling Brain activity changes with emotional words in different stages of psychosis.Soldevila-Matias, PauGarcia-Marti, GracianFuentes-Dura, InmaculadaRuiz, Juan CarlosGonzalez-Navarro, LauraGonzalez-Vivas, CarlosRadua, JoaquimSanjuan, JulioAuditory paradigmFEP patientsNeuroimaging fMRIchronic psychosis patientsemotional design modelBACKGROUND: To date, a large number of functional magnetic resonance imaging (fMRI) studies have been conducted on psychosis. However, little is known about changes in brain functioning in psychotic patients using an emotional auditory paradigm at different stages of the disease. Such knowledge is important for advancing our understanding of the disorder and thus creating more targeted interventions. This study aimed to investigate whether individuals with first-episode psychosis (FEP) and chronic schizophrenia show abnormal brain responses to emotional auditory processing and to compare the responses between FEP and chronic schizophrenia. METHODS: Patients with FEP (n = 31) or chronic schizophrenia (n = 23) and healthy controls (HCs, n = 31) underwent an fMRI scan while presented with both emotional and nonemotional words. RESULTS: Using HC as a reference, patients with FEP showed decreased right temporal activation, while patients with chronic schizophrenia showed increased bilateral temporal activation. When comparing the patient groups, individuals with FEP showed lower frontal lobe activation. CONCLUSION: To the best of our knowledge, this is the first study with an emotional auditory paradigm used in psychotic patients at different stages of the disease. Our results suggested that the temporal lobe might be a key issue in the physiopathology of psychosis, although abnormal activation could also be derived from a connectivity problem. There is lower activation in the early stage and evolution to greater activation when patients become chronic. This study highlights the relevance of using emotional paradigms to better understand brain activation at different stages of psychosis.CAMBRIDGE UNIV PRESS2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/16955EUROPEAN PSYCHIATRYISSN: 09249338ISSNe: 17783585reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p169552026-06-07T16:35:31Z
dc.title.none.fl_str_mv Brain activity changes with emotional words in different stages of psychosis.
title Brain activity changes with emotional words in different stages of psychosis.
spellingShingle Brain activity changes with emotional words in different stages of psychosis.
Soldevila-Matias, Pau
Auditory paradigm
FEP patients
Neuroimaging fMRI
chronic psychosis patients
emotional design model
title_short Brain activity changes with emotional words in different stages of psychosis.
title_full Brain activity changes with emotional words in different stages of psychosis.
title_fullStr Brain activity changes with emotional words in different stages of psychosis.
title_full_unstemmed Brain activity changes with emotional words in different stages of psychosis.
title_sort Brain activity changes with emotional words in different stages of psychosis.
dc.creator.none.fl_str_mv Soldevila-Matias, Pau
Garcia-Marti, Gracian
Fuentes-Dura, Inmaculada
Ruiz, Juan Carlos
Gonzalez-Navarro, Laura
Gonzalez-Vivas, Carlos
Radua, Joaquim
Sanjuan, Julio
author Soldevila-Matias, Pau
author_facet Soldevila-Matias, Pau
Garcia-Marti, Gracian
Fuentes-Dura, Inmaculada
Ruiz, Juan Carlos
Gonzalez-Navarro, Laura
Gonzalez-Vivas, Carlos
Radua, Joaquim
Sanjuan, Julio
author_role author
author2 Garcia-Marti, Gracian
Fuentes-Dura, Inmaculada
Ruiz, Juan Carlos
Gonzalez-Navarro, Laura
Gonzalez-Vivas, Carlos
Radua, Joaquim
Sanjuan, Julio
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Auditory paradigm
FEP patients
Neuroimaging fMRI
chronic psychosis patients
emotional design model
topic Auditory paradigm
FEP patients
Neuroimaging fMRI
chronic psychosis patients
emotional design model
description BACKGROUND: To date, a large number of functional magnetic resonance imaging (fMRI) studies have been conducted on psychosis. However, little is known about changes in brain functioning in psychotic patients using an emotional auditory paradigm at different stages of the disease. Such knowledge is important for advancing our understanding of the disorder and thus creating more targeted interventions. This study aimed to investigate whether individuals with first-episode psychosis (FEP) and chronic schizophrenia show abnormal brain responses to emotional auditory processing and to compare the responses between FEP and chronic schizophrenia. METHODS: Patients with FEP (n = 31) or chronic schizophrenia (n = 23) and healthy controls (HCs, n = 31) underwent an fMRI scan while presented with both emotional and nonemotional words. RESULTS: Using HC as a reference, patients with FEP showed decreased right temporal activation, while patients with chronic schizophrenia showed increased bilateral temporal activation. When comparing the patient groups, individuals with FEP showed lower frontal lobe activation. CONCLUSION: To the best of our knowledge, this is the first study with an emotional auditory paradigm used in psychotic patients at different stages of the disease. Our results suggested that the temporal lobe might be a key issue in the physiopathology of psychosis, although abnormal activation could also be derived from a connectivity problem. There is lower activation in the early stage and evolution to greater activation when patients become chronic. This study highlights the relevance of using emotional paradigms to better understand brain activation at different stages of psychosis.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/16955
url https://incliva.portalinvestigacion.com/publicaciones/16955
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
dc.source.none.fl_str_mv EUROPEAN PSYCHIATRY
ISSN: 09249338
ISSNe: 17783585
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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