Monitoring holograms for therapeutic ultrasound using passive cavitation beamforming

[EN] Acoustic holograms can generate cavitation patterns of complex spatial distribution by shaping and steering the focal spot of therapeutic ultrasound systems. However, when monitoring these systems by passive cavitation detection, off-axis therapeutical targets and the receiver directivity may n...

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Autores: Lamothe, Nathalie, Andrés-Bautista, Diana, Pineda-Pardo, J.A., CARRIÓN GARCÍA, ALICIA|||0000-0002-0630-6065, Camarena Femenia, Francisco|||0000-0002-6713-1414, Jimenez, Noe|||0000-0002-6539-670X
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/213955
Acceso en línea:https://riunet.upv.es/handle/10251/213955
Access Level:acceso abierto
Palabra clave:Acoustic holograms
Passive beamforming
Therapeutic ultrasound
Passive cavitation detector
FISICA APLICADA
id ES_74df4845c9bca9ea93acafc4f55bfaaf
oai_identifier_str oai:riunet.upv.es:10251/213955
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Monitoring holograms for therapeutic ultrasound using passive cavitation beamforming
title Monitoring holograms for therapeutic ultrasound using passive cavitation beamforming
spellingShingle Monitoring holograms for therapeutic ultrasound using passive cavitation beamforming
Lamothe, Nathalie
Acoustic holograms
Passive beamforming
Therapeutic ultrasound
Passive cavitation detector
FISICA APLICADA
title_short Monitoring holograms for therapeutic ultrasound using passive cavitation beamforming
title_full Monitoring holograms for therapeutic ultrasound using passive cavitation beamforming
title_fullStr Monitoring holograms for therapeutic ultrasound using passive cavitation beamforming
title_full_unstemmed Monitoring holograms for therapeutic ultrasound using passive cavitation beamforming
title_sort Monitoring holograms for therapeutic ultrasound using passive cavitation beamforming
dc.creator.none.fl_str_mv Lamothe, Nathalie
Andrés-Bautista, Diana
Pineda-Pardo, J.A.
CARRIÓN GARCÍA, ALICIA|||0000-0002-0630-6065
Camarena Femenia, Francisco|||0000-0002-6713-1414
Jimenez, Noe|||0000-0002-6539-670X
author Lamothe, Nathalie
author_facet Lamothe, Nathalie
Andrés-Bautista, Diana
Pineda-Pardo, J.A.
CARRIÓN GARCÍA, ALICIA|||0000-0002-0630-6065
Camarena Femenia, Francisco|||0000-0002-6713-1414
Jimenez, Noe|||0000-0002-6539-670X
author_role author
author2 Andrés-Bautista, Diana
Pineda-Pardo, J.A.
CARRIÓN GARCÍA, ALICIA|||0000-0002-0630-6065
Camarena Femenia, Francisco|||0000-0002-6713-1414
Jimenez, Noe|||0000-0002-6539-670X
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Física Aplicada
Escuela Técnica Superior de Ingeniería de Telecomunicación
Departamento de Comunicaciones
Escuela Técnica Superior de Arquitectura
Escuela Técnica Superior de Ingeniería Industrial
Escuela Politécnica Superior de Gandia
Instituto de Instrumentación para Imagen Molecular
European Social Fund
Generalitat Valenciana
Ministerio de Universidades
Agencia Estatal de Investigación
Ministerio de Ciencia e Innovación
Agència Valenciana de la Innovació
Ministerio de Ciencia, Innovación y Universidades
Universitat Politècnica de València
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Acoustic holograms
Passive beamforming
Therapeutic ultrasound
Passive cavitation detector
FISICA APLICADA
topic Acoustic holograms
Passive beamforming
Therapeutic ultrasound
Passive cavitation detector
FISICA APLICADA
description [EN] Acoustic holograms can generate cavitation patterns of complex spatial distribution by shaping and steering the focal spot of therapeutic ultrasound systems. However, when monitoring these systems by passive cavitation detection, off-axis therapeutical targets and the receiver directivity may not be aligned. In this paper, we present passive cavitation beamforming to monitor a therapeutical ultrasound system using holograms targeted to arbitrary locations, in which both therapeutic and passive cavitation monitoring systems use 3D-printed acoustic lenses. The therapeutic system uses an acoustic hologram to focus the ultrasound beam on the target, which is off-axis. Then, a second lens is designed to beamform the cavitation signals which emerge from the therapeutic target, steering the directivity of the passive cavitation detector in the direction of the therapeutic focus and, in addition, compensating for skull aberrations. The system is experimentally tested with an ex-vivo macaque skull and a blood vessel phantom with microbubbles. In addition, results are compared with a standard confocal configuration and an off-axis configuration in the absence of the monitor lens. A parametric study is performed by varying the amplitude of the emitted signal and the impact on the behaviour of the microbubbles is analysed based on the cavitation index values. Results show that monitoring holograms align the passive cavitation detector response with the focal spot of the targeted therapeutic transducer. These holograms encode a fixed beamformer for cavitation signals in reception, increasing the sensitivity of cavitation emission at the target. In this way, cavitation doses can be used to locally monitor the cavitation activity of microbubbles, thus opening a new path to low-cost monitoring of therapeutic ultrasound systems.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-09-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/213955
url https://riunet.upv.es/handle/10251/213955
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2022-142719OB-C21 LENTES HOLOGRAFICAS PARA EL TRATAMIENTO ULTRASONICO DE TRASTORNOS CEREBRALES
Generalitat Valenciana https://doi.org/10.13039/501100003359 CIGE%2F2021%2F175
Generalitat Valenciana https://doi.org/10.13039/501100003359 CIAICO%2F2023%2F052
Generalitat Valenciana https://doi.org/10.13039/501100003359 CIPROM%2F2021%2F003
Generalitat Valenciana https://doi.org/10.13039/501100003359 FDEGENT%2F2019%2F004
Generalitat Valenciana https://doi.org/10.13039/501100003359 IDIFEDER%2F2021%2F004
Ministerio de Ciencia, Innovación y Universidades https://doi.org/10.13039/100014440 RYC2021-034920-I
European Science Foundation https://doi.org/10.13039/501100000782 EDGJID%2F2021%2F189
Agència Valenciana de la Innovació https://doi.org/10.13039/501100016028 INNVA2%2F2022%2F11
Agència Valenciana de la Innovació https://doi.org/10.13039/501100016028 INNEST%2F2022%2F345
Ministerio de Universidades MIU Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 FPU19%2F00601
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Proyectos Consolidación Investigadora CNS2023-145707
Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 Contrato Juan de la Cierva Formación FJC2019-040453-I
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Monitoring holograms for therapeutic ultrasound using passive cavitation beamformingLamothe, NathalieAndrés-Bautista, DianaPineda-Pardo, J.A.CARRIÓN GARCÍA, ALICIA|||0000-0002-0630-6065Camarena Femenia, Francisco|||0000-0002-6713-1414Jimenez, Noe|||0000-0002-6539-670XAcoustic hologramsPassive beamformingTherapeutic ultrasoundPassive cavitation detectorFISICA APLICADA[EN] Acoustic holograms can generate cavitation patterns of complex spatial distribution by shaping and steering the focal spot of therapeutic ultrasound systems. However, when monitoring these systems by passive cavitation detection, off-axis therapeutical targets and the receiver directivity may not be aligned. In this paper, we present passive cavitation beamforming to monitor a therapeutical ultrasound system using holograms targeted to arbitrary locations, in which both therapeutic and passive cavitation monitoring systems use 3D-printed acoustic lenses. The therapeutic system uses an acoustic hologram to focus the ultrasound beam on the target, which is off-axis. Then, a second lens is designed to beamform the cavitation signals which emerge from the therapeutic target, steering the directivity of the passive cavitation detector in the direction of the therapeutic focus and, in addition, compensating for skull aberrations. The system is experimentally tested with an ex-vivo macaque skull and a blood vessel phantom with microbubbles. In addition, results are compared with a standard confocal configuration and an off-axis configuration in the absence of the monitor lens. A parametric study is performed by varying the amplitude of the emitted signal and the impact on the behaviour of the microbubbles is analysed based on the cavitation index values. Results show that monitoring holograms align the passive cavitation detector response with the focal spot of the targeted therapeutic transducer. These holograms encode a fixed beamformer for cavitation signals in reception, increasing the sensitivity of cavitation emission at the target. In this way, cavitation doses can be used to locally monitor the cavitation activity of microbubbles, thus opening a new path to low-cost monitoring of therapeutic ultrasound systems.This research has been supported by the Ministerio Español de Ciencia e Innovación and the Ministerio de Universidades grants FJC2019-040453-I, RYC2021-034920-I, FPU19/00601 and Agencia Estatal de Investigación grants PID2022-142719OB-C21 and CNS2023-145707 funded by MCIN/AEI/10.13039/501100011033; Agència Valenciana de la Innovació grants INNVA2/2022/11 and INNEST/2022/345; Generalitat Valenciana grants EDGJID/2021/189, CIGE/2021/175, CIAICO/2023/052, CIPROM/2021/003, FDEGENT/2019/004 and IDIFEDER/2021/004.ElsevierDepartamento de Física AplicadaEscuela Técnica Superior de Ingeniería de TelecomunicaciónDepartamento de ComunicacionesEscuela Técnica Superior de ArquitecturaEscuela Técnica Superior de Ingeniería IndustrialEscuela Politécnica Superior de GandiaInstituto de Instrumentación para Imagen MolecularEuropean Social FundGeneralitat ValencianaMinisterio de UniversidadesAgencia Estatal de InvestigaciónMinisterio de Ciencia e InnovaciónAgència Valenciana de la InnovacióMinisterio de Ciencia, Innovación y UniversidadesUniversitat Politècnica de ValènciaRepositorio Institucional de la Universitat Politècnica de València Riunet20242024-09-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/213955reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2022-142719OB-C21 LENTES HOLOGRAFICAS PARA EL TRATAMIENTO ULTRASONICO DE TRASTORNOS CEREBRALESGeneralitat Valenciana https://doi.org/10.13039/501100003359 CIGE%2F2021%2F175Generalitat Valenciana https://doi.org/10.13039/501100003359 CIAICO%2F2023%2F052Generalitat Valenciana https://doi.org/10.13039/501100003359 CIPROM%2F2021%2F003Generalitat Valenciana https://doi.org/10.13039/501100003359 FDEGENT%2F2019%2F004Generalitat Valenciana https://doi.org/10.13039/501100003359 IDIFEDER%2F2021%2F004Ministerio de Ciencia, Innovación y Universidades https://doi.org/10.13039/100014440 RYC2021-034920-IEuropean Science Foundation https://doi.org/10.13039/501100000782 EDGJID%2F2021%2F189Agència Valenciana de la Innovació https://doi.org/10.13039/501100016028 INNVA2%2F2022%2F11Agència Valenciana de la Innovació https://doi.org/10.13039/501100016028 INNEST%2F2022%2F345Ministerio de Universidades MIU Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 FPU19%2F00601Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Proyectos Consolidación Investigadora CNS2023-145707Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 Contrato Juan de la Cierva Formación FJC2019-040453-Iopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/2139552026-06-13T07:49:27Z
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