Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain

Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring h...

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Detalles Bibliográficos
Autores: Rodilla E, Lopez-Carmona MD, Cortes X, Cobos-Palacios L, Canales S, Saez MC, Campos-Escudero S, Rubio-Rivas M, Diez-Manglano J, Freire-Castro SJ, Vazquez-Piqueras N, Mateo-Sanchis E, Pesqueira-Fontan PM, Magallanes-Gamboa JO, Gonzalez-Garcia A, Madrid-Romero V, Tamargo-Chamorro L, Gonzalez Moraleja J, Villanueva-Martinez J, Gonzalez-Noya A, Suárez-Lombraña A, Gracia-Gutierrez A, Lopez Reboiro ML, Ramos-Rincon JM, Gomez-Huelgas R
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p8682
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/8682
Access Level:acceso abierto
Palabra clave:arterial stiffness
blood pressure
COVID-19
heart failure
hypertension
pulse pressure
Descripción
Sumario:Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure >= 60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (+/- 16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP) <120 and >= 140 mm Hg was a predictor of higher all-cause mortality (23.5% and 22.8%, respectively, P<0.001), compared with systolic BP between 120 and 140 mm Hg (18.6%). The 4379 patients with AS (36.0%) were older and had higher systolic and lower diastolic BP. Multivariate analysis showed that AS and systolic BP <120 mm Hg significantly and independently predicted all-cause in-hospital mortality (adjusted odds ratio [ORadj]: 1.27, P=0.0001; ORadj: 1.48, P=0.0001, respectively) after adjusting for sex (males, ORadj: 1.6, P=0.0001), age tertiles (second and third tertiles, ORadj: 2.0 and 4.7, P=0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj: 4.8 and 8.6, P=0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP <120 mm Hg had independent prognostic value for all-cause mortality in patients with COVID-19 requiring hospitalization.

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