Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults

Myocardial involvement during SARS-CoV-2 infection has been reported in many prior publications. We aim to study the prevalence and the clinical implications of acute myocardial injury (MIN) during SARS-CoV-2 infection, particularly in older patients. The method includes a longitudinal observational...

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Autores: Arnau-Barrés, Isabel, Pascual-Dapena, Ana, López Montesinos, Inmaculada, Gómez-Zorrilla, Silvia, Sorli Redó, M. Luisa, Herrero, Marta, Nogués Solán, Xavier, Montero, Milagros, Vázquez Ibar, Olga, Garcia Giralt, Natàlia, Miralles Basseda, Ramon, Güerri Fernández, Roberto
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/53559
Acesso em linha:http://hdl.handle.net/10230/53559
http://dx.doi.org/10.3390/jcm10163738
Access Level:Acceso aberto
Palavra-chave:SARS-CoV-2
Myocardial injury
Older adults
Prognosis
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spelling Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adultsArnau-Barrés, IsabelPascual-Dapena, AnaLópez Montesinos, InmaculadaGómez-Zorrilla, SilviaSorli Redó, M. LuisaHerrero, MartaNogués Solán, XavierMontero, MilagrosVázquez Ibar, OlgaGarcia Giralt, NatàliaMiralles Basseda, RamonGüerri Fernández, RobertoSARS-CoV-2Myocardial injuryOlder adultsPrognosisMyocardial involvement during SARS-CoV-2 infection has been reported in many prior publications. We aim to study the prevalence and the clinical implications of acute myocardial injury (MIN) during SARS-CoV-2 infection, particularly in older patients. The method includes a longitudinal observational study with all consecutive adult patients admitted to a COVID-19 unit between March-April 2020. Those aged ≥65 were considered as older adult group. MIN was defined as at least 1 high-sensitive troponin (hs-TnT) concentration above the 99th percentile upper reference limit with different sex-cutoff. Results. Among the 634 patients admitted during the period of observation, 365 (58%) had evidence of MIN, and, of them, 224 (61%) were older adults. Among older adults, MIN was associated with longer time to recovery compared to those without MIN (13 days (IQR 6-21) versus 9 days (IQR 5-17); p < 0.001, respectively. In-hospital mortality was significantly higher in older adults with MIN at admission versus those without it (71 (31%) versus 11 (12%); p < 0.001). In a logistic regression model adjusting by age, sex, severity, and Charlson Comorbidity Index, the OR for in-hospital mortality was 2.1 (95% CI: 1.02-4.42; p = 0.043) among those older adults with MIN at admission. Older adults with acute myocardial injury had greater time to clinical recovery, as well as higher odds of in-hospital mortality.MDPI202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/53559http://dx.doi.org/10.3390/jcm10163738reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCopyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/535592026-05-29T05:05:01Z
dc.title.none.fl_str_mv Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults
title Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults
spellingShingle Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults
Arnau-Barrés, Isabel
SARS-CoV-2
Myocardial injury
Older adults
Prognosis
title_short Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults
title_full Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults
title_fullStr Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults
title_full_unstemmed Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults
title_sort Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults
dc.creator.none.fl_str_mv Arnau-Barrés, Isabel
Pascual-Dapena, Ana
López Montesinos, Inmaculada
Gómez-Zorrilla, Silvia
Sorli Redó, M. Luisa
Herrero, Marta
Nogués Solán, Xavier
Montero, Milagros
Vázquez Ibar, Olga
Garcia Giralt, Natàlia
Miralles Basseda, Ramon
Güerri Fernández, Roberto
author Arnau-Barrés, Isabel
author_facet Arnau-Barrés, Isabel
Pascual-Dapena, Ana
López Montesinos, Inmaculada
Gómez-Zorrilla, Silvia
Sorli Redó, M. Luisa
Herrero, Marta
Nogués Solán, Xavier
Montero, Milagros
Vázquez Ibar, Olga
Garcia Giralt, Natàlia
Miralles Basseda, Ramon
Güerri Fernández, Roberto
author_role author
author2 Pascual-Dapena, Ana
López Montesinos, Inmaculada
Gómez-Zorrilla, Silvia
Sorli Redó, M. Luisa
Herrero, Marta
Nogués Solán, Xavier
Montero, Milagros
Vázquez Ibar, Olga
Garcia Giralt, Natàlia
Miralles Basseda, Ramon
Güerri Fernández, Roberto
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SARS-CoV-2
Myocardial injury
Older adults
Prognosis
topic SARS-CoV-2
Myocardial injury
Older adults
Prognosis
description Myocardial involvement during SARS-CoV-2 infection has been reported in many prior publications. We aim to study the prevalence and the clinical implications of acute myocardial injury (MIN) during SARS-CoV-2 infection, particularly in older patients. The method includes a longitudinal observational study with all consecutive adult patients admitted to a COVID-19 unit between March-April 2020. Those aged ≥65 were considered as older adult group. MIN was defined as at least 1 high-sensitive troponin (hs-TnT) concentration above the 99th percentile upper reference limit with different sex-cutoff. Results. Among the 634 patients admitted during the period of observation, 365 (58%) had evidence of MIN, and, of them, 224 (61%) were older adults. Among older adults, MIN was associated with longer time to recovery compared to those without MIN (13 days (IQR 6-21) versus 9 days (IQR 5-17); p < 0.001, respectively. In-hospital mortality was significantly higher in older adults with MIN at admission versus those without it (71 (31%) versus 11 (12%); p < 0.001). In a logistic regression model adjusting by age, sex, severity, and Charlson Comorbidity Index, the OR for in-hospital mortality was 2.1 (95% CI: 1.02-4.42; p = 0.043) among those older adults with MIN at admission. Older adults with acute myocardial injury had greater time to clinical recovery, as well as higher odds of in-hospital mortality.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/53559
http://dx.doi.org/10.3390/jcm10163738
url http://hdl.handle.net/10230/53559
http://dx.doi.org/10.3390/jcm10163738
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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