Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults

Myocardial involvement during SARS-CoV-2 infection has been reported in many prior publications. We aim to study the prevalence and the clinical implications of acute myocardial injury (MIN) during SARS-CoV-2 infection, particularly in older patients. The method includes a longitudinal observational...

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Detalles Bibliográficos
Autores: Arnau-Barrés, Isabel, Pascual-Dapena, Ana, López Montesinos, Inmaculada, Gómez-Zorrilla, Silvia, Sorli Redó, M. Luisa, Herrero, Marta, Nogués Solán, Xavier, Montero, Milagros, Vázquez Ibar, Olga, Garcia Giralt, Natàlia, Miralles Basseda, Ramon, Güerri Fernández, Roberto
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/53559
Acceso en línea:http://hdl.handle.net/10230/53559
http://dx.doi.org/10.3390/jcm10163738
Access Level:acceso abierto
Palabra clave:SARS-CoV-2
Myocardial injury
Older adults
Prognosis
Descripción
Sumario:Myocardial involvement during SARS-CoV-2 infection has been reported in many prior publications. We aim to study the prevalence and the clinical implications of acute myocardial injury (MIN) during SARS-CoV-2 infection, particularly in older patients. The method includes a longitudinal observational study with all consecutive adult patients admitted to a COVID-19 unit between March-April 2020. Those aged ≥65 were considered as older adult group. MIN was defined as at least 1 high-sensitive troponin (hs-TnT) concentration above the 99th percentile upper reference limit with different sex-cutoff. Results. Among the 634 patients admitted during the period of observation, 365 (58%) had evidence of MIN, and, of them, 224 (61%) were older adults. Among older adults, MIN was associated with longer time to recovery compared to those without MIN (13 days (IQR 6-21) versus 9 days (IQR 5-17); p < 0.001, respectively. In-hospital mortality was significantly higher in older adults with MIN at admission versus those without it (71 (31%) versus 11 (12%); p < 0.001). In a logistic regression model adjusting by age, sex, severity, and Charlson Comorbidity Index, the OR for in-hospital mortality was 2.1 (95% CI: 1.02-4.42; p = 0.043) among those older adults with MIN at admission. Older adults with acute myocardial injury had greater time to clinical recovery, as well as higher odds of in-hospital mortality.

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