Diverse methods with stereoselective induction in the asymmetric Biginelli reaction

The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric synthetic advances in the formation of dihydropyr...

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Detalles Bibliográficos
Autores: Díaz Fernández, Marcos, Algarra González, Manuel, Calvo Losada, Saturnino, Quirante, José Joaquín, Sarabia, Francisco, Pino-González, María Soledad
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/51961
Acceso en línea:https://hdl.handle.net/2454/51961
Access Level:acceso abierto
Palabra clave:Pyrimidines
Multicomponent reactions
Asymmetric
Enantioselective
N-heterocycles
Biginelli reaction
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spelling Diverse methods with stereoselective induction in the asymmetric Biginelli reactionDíaz Fernández, MarcosAlgarra González, ManuelCalvo Losada, SaturninoQuirante, José JoaquínSarabia, FranciscoPino-González, María SoledadPyrimidinesMulticomponent reactionsAsymmetricEnantioselectiveN-heterocyclesBiginelli reactionThe relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric synthetic advances in the formation of dihydropyrimidinones (DHPMs), dihydropyrimidinethiones (DHPMTs), and related compounds. The relevant bibliography on general processes in the Biginelli reaction and some methods of separation of isomers have also been referenced.Financial support has been received from the Spanish Ministry of Science and Innovation RTI2018-098296-BI00 (MINECO and FEDER), and M. Algarra would like to thank the Ministry of Science and Innovation (MCIN/AEI/https://doi.org/10.13039/501100011033) for their support under the grant number PID2021-122613OB-I00MDPI PublishingInstitute for Advanced Materials and Mathematics - INAMAT22024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/51961reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-098296-BI00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122613OB-I00© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/519612026-06-17T12:41:47Z
dc.title.none.fl_str_mv Diverse methods with stereoselective induction in the asymmetric Biginelli reaction
title Diverse methods with stereoselective induction in the asymmetric Biginelli reaction
spellingShingle Diverse methods with stereoselective induction in the asymmetric Biginelli reaction
Díaz Fernández, Marcos
Pyrimidines
Multicomponent reactions
Asymmetric
Enantioselective
N-heterocycles
Biginelli reaction
title_short Diverse methods with stereoselective induction in the asymmetric Biginelli reaction
title_full Diverse methods with stereoselective induction in the asymmetric Biginelli reaction
title_fullStr Diverse methods with stereoselective induction in the asymmetric Biginelli reaction
title_full_unstemmed Diverse methods with stereoselective induction in the asymmetric Biginelli reaction
title_sort Diverse methods with stereoselective induction in the asymmetric Biginelli reaction
dc.creator.none.fl_str_mv Díaz Fernández, Marcos
Algarra González, Manuel
Calvo Losada, Saturnino
Quirante, José Joaquín
Sarabia, Francisco
Pino-González, María Soledad
author Díaz Fernández, Marcos
author_facet Díaz Fernández, Marcos
Algarra González, Manuel
Calvo Losada, Saturnino
Quirante, José Joaquín
Sarabia, Francisco
Pino-González, María Soledad
author_role author
author2 Algarra González, Manuel
Calvo Losada, Saturnino
Quirante, José Joaquín
Sarabia, Francisco
Pino-González, María Soledad
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institute for Advanced Materials and Mathematics - INAMAT2
dc.subject.none.fl_str_mv Pyrimidines
Multicomponent reactions
Asymmetric
Enantioselective
N-heterocycles
Biginelli reaction
topic Pyrimidines
Multicomponent reactions
Asymmetric
Enantioselective
N-heterocycles
Biginelli reaction
description The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric synthetic advances in the formation of dihydropyrimidinones (DHPMs), dihydropyrimidinethiones (DHPMTs), and related compounds. The relevant bibliography on general processes in the Biginelli reaction and some methods of separation of isomers have also been referenced.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/51961
url https://hdl.handle.net/2454/51961
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-098296-BI00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122613OB-I00
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI Publishing
publisher.none.fl_str_mv MDPI Publishing
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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