Diverse methods with stereoselective induction in the asymmetric Biginelli reaction

The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric synthetic advances in the formation of dihydropyr...

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Detalles Bibliográficos
Autores: Díaz Fernández, Marcos, Algarra González, Manuel, Calvo Losada, Saturnino, Quirante, José Joaquín, Sarabia, Francisco, Pino-González, María Soledad
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/51961
Acceso en línea:https://hdl.handle.net/2454/51961
Access Level:acceso abierto
Palabra clave:Pyrimidines
Multicomponent reactions
Asymmetric
Enantioselective
N-heterocycles
Biginelli reaction
Descripción
Sumario:The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric synthetic advances in the formation of dihydropyrimidinones (DHPMs), dihydropyrimidinethiones (DHPMTs), and related compounds. The relevant bibliography on general processes in the Biginelli reaction and some methods of separation of isomers have also been referenced.